Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"Disease Modeling"”.
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Large Scale Disease Modeling
<p>In this we study large scale disease modeling. After understanding the mechanics behind the SIR disease model in an ODE sense, we will apply this knowledge to model disease spread in more and more increasing advanced cellular automata. Eventually, some of our cellular automata will include long …
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Engineered Heart Tissues for Advanced Disease Modeling
… (DMD), a severe, X-linked, neuromuscular disease, the mechanisms underlying the associated dilated cardiomyopathy (DCM) are not completely understood. This is due in part to the lack of suitable animal models of DMD-associated DCM which can accurately reproduce the disease’s progression in …
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Machine learning and data analytics for liver disease modeling
… (PSC) is a rare, progressive cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical therapies remain …
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Applications of genome editing for disease modeling in mice
… role of genetic elements in normal biology and disease. Recently developed genome editing technologies are now making it possible to modify the genome in its endogenous context, opening up exciting possibilities for understanding its function. The RNA-guided endonuclease Cas9 from microbial type …
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Targeting nucleic acids for pancreatic cancer: disease modeling and therapy
… bridging our understanding of PDAC as a genetic disease to the clinic. Furthermore, the modular aspect of these self-assembled particles permits them to accommodate alternate cargoes or targeting domains, and we have proposed that tandem peptide complexes could be extended to applications outside …
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Development of a High-Throughput Human iPSC Chondrogenesis Platform and Applications for Arthritis Disease Modeling
… for applications in regenerative medicine, disease modeling, and drug screening. In many cases, however, these differentiation approaches are poorly controlled and generate heterogeneous cell populations. In this dissertation, we demonstrate robust cartilaginous matrix production in multiple …
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Epidemiological Studies of Northern Corn Leaf Blight on Corn Inbreds: Loss Assessment and Disease Modeling
… generally have lower tolerance to stress (e.g. disease) and yield less than hybrids. Inbreds are grown to produce hybrid seed and are intensively managed because of the need to control pollen and fungicidal control of disease on inbreds is economically feasible. Little is known, however, of the …
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Harnessing In Silico platform for Vaccine Discovery, Disease Modeling, and Immunotoxicity Prediction in Pandemic and Emergency Scenarios
Il mondo moderno affronta sfide senza precedenti derivanti da pandemie ed emergenze, richiedendo soluzioni innovative per una gestione efficace. Questa tesi affronta problematiche di salute globale utilizzando strumenti computazionali avanzati per la scoperta di vaccini, la modellazione delle …
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Applications for human neural stem cell-derived motor neurons in amyotrophic lateral sclerosis: Cell replacement therapy and disease modeling
… sclerosis (ALS) is an incurable neurological disease characterized by the selective degeneration of spinal and upper motor neurons. One approach in the development of therapies for ALS is to explore the potential of human fetal neural stem cells (hNSCs) to replace lost motor neurons. The …
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Modeling Alzheimer's Disease Using Cellular Reprogramming Technologies
… great potential utility for patient-specific disease modeling and for applications in regenerative medicine. Current models of neurodegenerative diseases are limited in their representation of disease phenotypes and there is an essential need for human cellular models of neurodegenerative …
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From iPSCs to Engineered Heart and Liver Models: Modulating Genetic and Extracellular State for Maturity
… fully patient-specific tissues suitable for disease modeling. Together, these advancements establish improved hepatic and cardiac platforms that enhance maturation, scalability, and predictive function, providing valuable tools for disease modeling and preclinical drug testing and disease …
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Flexure-Based Device Enables Precise Quantitative Monitoring of Muscle Performance
… of clinical applications such as neuromuscular disease modeling and drug therapy testing. The contractile mechanisms of engineered muscle are often quantified by constraining the muscle on an elastomeric scaffold and measuring the scaffold’s deformation; however, structural imperfections in the …
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Engineering micro-perfusable scaffolds for MesoPhysiological Systems using projection Micro-StereoLithography
… animal models for the development of new drugs, disease modeling and biological research. The organs in the human body are continuously perfused via a dense network of blood vessels delivering oxygen, nutrients and biomolecules locally while clearing waste materials produced by the tissue. As a …
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Analysis of matrix and striosomal cell activity to explore and predict mouse behavior in 'T' maze
… and matrix cells in wild type and Huntington disease modeling mice and how they are linked to cost-benefit decision-making. This paper will analyze and model the neural data and train a classifier that can predict the mouse's behavior as it runs a T-maze. The paper finds some support for the …
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Ipsc Based Gene Correction and Disease Model of A New Class of Lgmd Due to Poglut1 Mutation
… <p>To test this, we have used iPSCs for disease modeling and rescue experiments. Using a CRISPR based gene targeting method, we aimed to correct the point mutation and restore POGLUT1 function, thus restoring Notch signaling activity. Following correction, iPSC-derived gene corrected …
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The core mammalian pluripotency network in induced pluripotent stem cell (iPSC) formation : models for genetic and epigenetic reprogramming
… the capacity to revolutionize basic research in disease modeling and drug discovery. These promises notwithstanding, the economics of iPSC formation--which remains a slow, inefficient, expensive, and laborious process--still stand in the way of fully making use of this extraordinary technology. …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
<p>Chronic kidney disease (CKD) is a degenerative disorder that affects millions of people worldwide and there are no targeted therapeutics. Given the global burden and increasing prevalence of CKD, the kidneys represent an attractive target for regenerative medicine. The most severe forms of CKD …
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Optical Coherence Tomography Angiography for Imaging and Analysis of the Choriocapillaris in Late Age-Related Macular Degeneration
… macular degeneration (AMD), a progressive disease of the retina and choroid, is a leading cause of vision loss. At present, AMD pathogenesis remains incompletely understood, and approved treatments only exist for certain AMD subtypes. In this thesis, we investigate AMD pathophysiology with …
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Soft Robotic Platforms for the Simulation of Cardiovascular Disease and Device Development
… the utilization of high-fidelity models of human disease. The closer these models emulate the intricacy of pathophysiological phenomena driving diseases and their effects, the greater their potential impact on clinical medicine. This thesis delves into the exploration of soft robotics in disease …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite cells (SCs) are essential for new muscle fiber formation; however, they lose their native quiescent state upon isolation, making in vitro studies of human SC function challenging. To optimally promote SC …
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