Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 19915 for “"Disease"”.
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Understanding Disease and Disease Relationships Using Transcriptomic Data
… its potential to deepen our understanding of disease; for example, by revealing gene expression patterns shared between diseases. However, key questions remain around the strength of the transcriptomic signal of disease and the identification of meaningful commonalities between datasets, which …
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Prognostication and disease monitoring in fibrotic interstitial lung disease
Introduction Fibrotic interstitial lung disease (f-ILD) causes significant morbidity and mortality worldwide. Progressive pulmonary fibrosis (PPF) describes a cohort of patients who develop progressive disease despite standard treatment. To provide optimal care, it is vital to identify those …
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Procerum root disease physiology and disease interactions with ozone
Procerum root disease of eastern white pine (Pinus strobus L.), caused by Leptographium procerum (Kendr.) Wingf., has been epidemic in Virginia Christmas tree plantations since 1990. Symptoms of chlorosis, wilt, and decreased apical growth resemble those of water stress. Resin infiltration of the …
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Mathematical modelling of host-disease-drug interactions in HIV disease
… aspect in the clinical management of HIV disease, namely drug pharmacokinetics. It is clear that time-dependent changes in in vivo drug concentration could have an impact on the antiviral effect, and also influence decisions on dosing intervals. We present a framework that provides an …
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CD166 modulates disease progression and osteolytic disease in multiple myeloma
… inoculated with CD166KD cells showed delayed disease progression and prolonged survival compared to mice receiving mock transduced cells. To examine the potential role of CD166 in osteolytic lesions, we first used a novel Ex Vivo Organ Culture Assay (EVOCA) which creates an in vitro 3D system …
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Kikuchi Disease in Korean Children : Clinical Features and Disease Courses
BACKGROUND: Kikuchi’s disease (KD) is a benign disorder with lymphadenopathy, and prevalent in young Asian women. The presentations mimic some serious diseases, and the biopsy of lymph nodes is the only definite diagnostic tool. We analyzed data from a series of pediatric cases and suggest proper …
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Assessing Disease Modifying Therapies in Autosomal Dominant Polycystic Kidney Disease
… growth in autosomal dominant polycystic kidney disease (ADPKD) and is a key therapeutic target. Evaluation of high water intake (HWI) as an alternative to pharmacological vasopressin blockade is supported by patients. However the feasibility, safety and adherence-promoting strategies required to …
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Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… in the aetiology and progression of Parkinson’s disease (PD). Epidemiological studies have shown that the risk of developing PD is linked to polymorphisms in immune-related genes, increased by the presence of inflammatory conditions and reduced by the use of immunosuppressant and …
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X Disease | Disease X: Medical Mystery-Solving and Epidemiological Change
… in the face of new, unknown, emerging diseases. It uses two cases, Australian X Disease of the early 1900s and Disease X of the dawning 2000s, to broadly interrogate how medical mystery-solvers marshall forms of experimentation and classification to identify and contain unknown …
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Sickle cell disease
Sickle cell disease is a group of disorders that affects hemoglobin, and causes distorted sickle- or crescent- shaped red blood cells. It is a genetic disease acquired by the inheritance of two abnormal hemoglobin S genes (HbS), one from each parent. SCD is most common among people from Africa, the …
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Sleep, Perivascular Spaces, and Cognition in Alzheimer's Disease and Parkinson's Disease
… conditions, such as Alzheimer’s disease and Parkinson’s disease. Two factors that are likely related to and may contribute to these cognitive deficits are sleep changes and enlarged perivascular spaces, which are an indicator of cerebral small vessel disease. In addition to being …
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Disease mechanisms and markers of progression in cerebral small vessel disease
Introduction <br>Cerebral small vessel disease (SVD) is a common disease process accounting for a quarter of all ischaemic strokes, around 80% of haemorrhagic strokes, and is the major contributor to vascular cognitive impairment and dementia. Despite it being a major public health burden, …
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Visual correlates of functional difficulties in Parkinson's disease and Alzheimer's disease
Although motor dysfunction in Parkinson's disease (PD) and memory deficits in Alzheimer's disease (AD) are the respective hallmark symptoms, both neurodegenerative disorders are also associated with significant disruptions in visual functioning. In PD, visuospatial function is impaired, …
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The Pathophysiological Mechanisms of Alzheimer's Disease; Investigating Therapeutic Interventions for Disease Onset
<p>Alzheimer’s Disease is a multifarious disease that progressively affects more people as both the proportion of older adults in the population and life expectancy increase in both the United States and worldwide. This devastating disease is a result of rampant neuronal loss in the memory centers …
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Effect of Cigarette Smoking on Disease Progression in Idiopathic Parkinson's Disease Patients
… the development of idiopathic Parkinson’s disease (IPD). Despite this, there have been few studies focusing on whether cigarette smoking is able to slow IPD disease progression. The few that have examined this issue must be regarded with care due to their intrinsic methodological problems …
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The neuroinflammatory basis of disease progression and cognitive impairment in Parkinson's disease
Parkinson’s disease (PD) is classically defined as a movement disorder, but a large proportion of patients also develop cognitive dysfunction as the disease progresses. Currently, it is not fully understood why some patients experience mainly movement-related features, whilst others suffer from a …
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Evaluation of immunomodulatory mediators in chronic obstructive pulmonary disease and cardiovascular disease
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are among the leading causes of mortality and poor health burden in the world. Both COPD and CVD often co-exist, due to shared risk factors and common pathophysiological pathways. There is an unmet need for effective …
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Parity and Cardiovascular Disease
Introduction: Several lines of evidence suggest that increased gravidity and/or parity is associated with increased risk for clinical cardiovascular events although there are no data on the effects on central aortic stiffness or remodelling. We examined the relationship between live births and …
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Tuberculosis: The Opportunistic Disease
Tuberculosis is an ancient disease caused by one of the most virulent and fatal biological agents; Mycobacterium tuberculosis (M. tuberculosis). Active pulmonary tuberculosis (TB) infection, which was nearly eradicated a generation ago, started to reemerge in a concerning manner in the late 1980's …
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Origin of disease-obesity
… of obesity. this study show that obesity as a disease is a wide and complex phenomenon and how each different view of obesity lead to the high prevalence of obesity.
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