Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Discoidin Domain Receptor-1"”.
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… and chemoresistance by activating cell surface receptors on tumor cells. Fibrillar collagens bind the collagen-specific receptor tyrosine kinase discoidin domain receptor 1 (DDR1), implicated in regulating cell proliferation, migration, adhesion, ECM remodeling, and response to growth factors. …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… Stiffness is sensed by matrix-binding receptors and transmitted through the cytoskeleton by actomyosin contractility. The work presented in this thesis identifies how Discoidin Domain Receptor-1 (DDR1) mediates stiffness sensing and how this influences vascular smooth muscle cell (VSMC) …
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Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
… signaling pathway occur frequently in estrogen receptor–positive (ER-positive) breast tumors. Patients with ER-positive, human epidermal growth factor receptor 2–negative (HER2-negative) metastatic breast cancer are often treated with cyclin-dependent kinase (CDK4/6) inhibitors such as …
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RUOLO DELL'ISOFORMA A DEL RECETTORE INSULINICO E DEL SUO PARTNER MOLECOLARE DDR1 NEL CANCRO AL SENO
L’iperespressione dell'isoforma A del recettore dell'insulina (IR-A) potrebbe svolgere un ruolo nella progressione del cancro. L'IR ha un ruolo metabolico predominante nella fisiologia, ma il ruolo potenziale dell'IR-A nella riprogrammazione metabolica del cancro è sconosciuto. Obiettivo dello …