Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Dis3"”.
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DISSECTING THE CLINICAL AND BIOLOGICAL RELEVANCE OF DIS3 GENE IN MULTIPLE MYELOMA
… biomarkers and putative therapeutic targets. DIS3 (chr.13q22.1 localization) is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of different species of RNA. Recently, aberrant expression of DIS3 has been …
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Genetic Analysis of Rna Exosome Complex Cofactors
… one or two catalytic subunits, including Rrp44/Dis3 and Rrp6 in yeast and DIS3 or DIS3L and RRP6/EXOSC10 in humans. The RNA exosome complex plays an essential role in RNA processing and degradation, which is vital for homeostatic gene expression. Mutations that affect RNA exosome complex …
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Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
<p>The RNA exosome is an essential 3’-5 ribonuclease that processes or degrades a variety of RNA species in eukaryotes. It is composed of nine structural cores and one catalytic subunit, Rrp44. Structural studies captured two different conformations of Rrp44, Rrp44<sup>ch</sup> (channel) and …