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Showing 1 to 9 of 9 for “"Dirofilaria immitis"”.
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The identification of novel cys-loop receptor genes in Dirofilaria immitis
Dirofilaria immitis is a parasitic nematode responsible for canine heartworm disease. Currently, heartworm treatments rely primarily on a single drug class – the macrocyclic lactones – but anthelmintic resistance is emerging. Cys-loop ligand-gated ion channels are an untapped source for drug …
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Light and Electron Microscopy of Dirofilaria Immitis (Leidy) in Aedes Aegypti (Linnaeus)
Made available in DSpace on 2014-12-11T21:33:45Z (GMT). No. of bitstreams: 1 7219790.pdf: 8157301 bytes, checksum: 6073d1ccdab353561c3b4725260aa0de (MD5) Previous issue date: 1972
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Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
Dirofilaria immitis is a mosquito-transmitted parasitic nematode that can cause debilitating disease in dogs. D. immitis is present in Canada and over the years has increased in prevalence due to several factors including climate change. Anthelmintic resistance is becoming increasingly problematic …
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Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
Dirofilaria immitis, otherwise known as heartworm, is a parasite that infects the hearts of dogs and causes serious health consequences. While preventative treatments are available drug resistance is developing at an alarming rate. Cystine-loop ligand-gated ion channels are important receptors in …
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La Crosse virus and Dirofilaria immitis: Abundance of Potential Vectors in Southwestern Virginia and the Effects of Dual Infection on Aedes albopictus and Ochlerotatus triseriatus
… overlaps the region of highest infection for Dirofilaria immitis, the nematode that cause canine heartworm disease. Ae. albopictus and Oc. triseriatus are important vectors of La Crosse virus and among the numerous species able to transmit D. immitis. In this study, Aedes albopictus and …
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In-vitro analysis of microfilariae phenotypic responses induced by small molecules and dsRNA targeting receptor pathways
Filarial nematodes such as Brugia malayi and Dirofilaria immitis pose a significant threat to humans and companion animals. Current methods of control include a range of anthelmintics. However, with resistance on the rise, drug target discovery and development are urgently needed. This study …
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Identification of surface accessible proteins in parasitic nematode extracellular vesicles
… diseases. Helminth infections, including dirofilariasis and ascariasis, are a global health concern, but current diagnostic tools for these infections are invasive and suboptimal. Leveraging parasitic nematode EVs to address this challenge is appealing, but progress in identifying …
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Filarial infection in mosquitoes of Northern California
… representing six mosquito species. The DNA of Dirofilaria immitis (n=6, MIR=0.26); Setaria yehi (n=9, MIR=1.44); Splendidofilaria sp. (n=4, MIR=0.20); unknown filarial parasites A (n=2, MIR=0.09), B (n=1, MIR=0.41), and C (n=1, MIR=0.05) were detected in Aedes increpitus, Aedes sierrensis, …
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BEHAVIOR, POPULATION STRUCTURE, PARASITISM, AND OTHER ASPECTS OF COYOTE ECOLOGY IN SOUTHERN ARIZONA
… cahirensis (3%), Mastophorus numidica (1%), and Dirofilaria immitis (2%); and 2 acanthocephalans, including Oncicola canis (46%) and Pachysentis canicola (1%). Pups and females were subject to greater collective endoparasite burdens. Variations in incidence and intensity of infection were also …