Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Dirichlet-multinomial"”.
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Cluster analysis of microbiome data via mixtures of Dirichlet-multinomial regression models
… is an active area of research. Previously, a Dirichlet-multinomial regression framework has been suggested to model this relationship, but it did not account for any latent group structure which has been observed across microbiome samples which share similar biota compositions (known as …
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Models of intelligence operations
… of the original MABA problem. Both a discrete Dirichlet-Multinomial and a continuous Exponential-Gamma-Gamma implementation of the MABA problem are developed, where the latter also models uncertainty in the processor's own ability to accurately assess the importance of sampled items.
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
… endpoints under a unified framework. We use a Dirichlet-multinomial model to accommodate different types of endpoints. At each interim, the go/no-go decision is made by evaluating a set of posterior probabilities of the events of interest, which is optimized to maximize power or minimize the …
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Compositional models for mutational signature analysis
… signatures, and copy number signatures. The Dirichlet-multinomial mixed effects model for single-nucleotide data is shown to have good sensitivity compared to existing fixed-effects alternatives, and higher specificity than compositional models that do not allow any overdispersion. Similarly, …
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Bayesian Methods to Characterize Uncertainty in Predictive Modeling of the Effect of Urbanization on Aquatic Ecosystems
… this prior with available data using conjugate Dirichlet-multinomial distribution forms. The resulting models elucidate differences between regional responses to urbanization (particularly due to background agriculture and precipitation) and address the influences of multiple urban induced …
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Towards high quality, scalable education: Techniques in automated assessment and probabilistic user behavior modeling
There are two primary challenges for instructors in offering a high-quality course at large scale. The first is scaling educational experiences to such a large audience. The second major challenge encountered is that of enabling adaptivity of the educational experience. This thesis addresses both …