Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Direct pathway"”.
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… decades ago, the precise contribution that the direct (recognition of intact allogeneic MHC) and indirect (recognition of self-MHC restricted allopeptide) pathways make to allograft rejection remains incompletely understood. In this thesis, murine models of heterotopic cardiac transplantation …
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The Regulation of Effort Exertion by the Nucleus Accumbens Core
… there are two main types of neurons, the direct and indirect pathway neurons, that play different roles in behavior and project to different downstream structures. The accumbens has also traditionally been divided into two subregions, the core and the shell. Much of what is known about …
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Poor Reading Ability as a Risk Factor for Alcohol Use in College Students
… without LD. One theory suggests that LD may be indirectly related to alcohol use, but there does not appear to be research examining whether there is a direct pathway between LD and alcohol use. The goals of this study were to better understand the relation between reading and alcohol use in …
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Mesoporous ZnO/TiO2 nanowire heterojunction photo-anodes for quantum-dot sensitised solar cells
… conditions and offer design versatility, opening pathways for integration into diverse environments and products. This ongoing research is vital for developing next-generation solar cells that are not only more efficient and affordable but also more adaptable to various energy demands, …
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The road to high performance single walled carbon nanotube thin film transistors: purification, densification, and integration
… synthesis and processing, thereby completing a direct pathway to achieve complex, high performance, and highly integrated SWNT electronics, sensors, or other devices.
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Novel Nanostructured Titania and Titania Nanocomposites for Photovoltaics and Photocatalysis
… ordered structure of nanotube array also offers direct pathway for fast electron transport. Moreover, Ag nanoparticles deposited onto TiO2 nanotubes function as reservoirs for photogenerated electrons to improve charge separation and facilitate catalytic reactions.
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… in Pdyn+, Adora2a+ and ChAT+ (markers for direct pathway, indirect pathway, and cholinergic interneurons, respectively). Following stress exposure, 5-HT1B transcript was selectively elevated in Pdyn+ cells of the mNAc. These findings suggest that Dyn/KOR regulates serotonin activation of …
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Principal Ownership of an Instructional Initiative: Advancing a Conceptual Framework for the Study of Leadership
… relationships are plausible. Significant pathways are found between the antecedents and the ownership behavior, and between the behavior and teacher collaboration. Mediational analysis of the pathways between principals' ownership behavior and the reform's reported influence on classroom …
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Striatal Microcircuits Underlying Control of Actions
… it is unclear how fast the animal moved, in what direction, or what effectors were used. The following experiments were designed to investigate the role of striatal neurons in controlling movement velocity in mice. The first set of experiments (Chapter 2) examined the relationship between striatal …
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Exploring the Career Pathways, Professional Integration and Lived Experiences of Regulated Nurses in Ontario, Canada
… of nurses, this study explores the career pathways and experiences of immigrant and Canadian-born nurses in two Ontario cities utilizing a qualitative research design consisting of 70 in-depth interviews. Differences in career entry and experiences of workplace conflict across immigration …
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Mechanism of Hip Dysplasia and Identification of the Least Energy Path for its Treatment by using the Principle of Stationary Potential Energy
… of treatment is the use of Pavlik Harness, which directs the femoral head toward the natural position inside the acetabulum. This dissertation presents a developed method for identifying the least energy path that the femoral head would follow during reduction. This is achieved by utilizing a …
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Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
… preferentially expressed in neostriatal efferent pathways and PDE10A inhibitors (PDE10i) have been shown to target dopamine signaling mechanisms. Studies here have utilized PDE10i to understand the balance of activation of medium spiny neurons in the indirect pathway versus activation of the …
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Carbazole-based porous organic polymers for photocatalytic hydrogen evolution
Photocatalytic water splitting is a direct pathway to store solar energy in chemicals. Within the last decade, porous organic polymers (POPs) proved to be promising candidates to be applied as photocatalyst. Due to the variety of building blocks, the optical properties can be tuned towards the …
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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking
… Showing the activity of SPNs of both in-/direct pathways may help elucidate mechanisms by which l-DOPA increases motor activity to normal and sometimes abnormal levels; such mechanistic information would advance understanding about how DA is such a potent motor stimulant.</p> <p>To this …
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Methods for monitoring the human circadian rhythm in free-living
… primarily through exposure to light. A direct pathway from the eyes to the suprachiasmatic nucleus, where the circadian clock resides, is used to synchronise the circadian clock to external light-dark cycles. In modern society, with the ability to work anywhere at anytime and a full …
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The Multifaceted Implications of Light for Psychological Well-Being and Mood
… of light on mood. The first study focused on the direct pathway between light and mood, aiming to predict mood outcomes based on the amount of intrinsically photosensitive retinal ganglion cells (ipRGC) stimulation from polychromatic light in healthy individuals. The second and third studies …
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Genetic Dissection of Neural Circuits Underlying Value Based Decision Making
… of two dominant cell types in the NAc, direct and indirect pathway medium spiny neurons (MSNs), showed partially overlapping but distinct behavioral effects. Inactivation of direct pathway MSNs showed the stronger effect on learning while inactivation of indirect pathway MSNs also showed …
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Understanding cation catalytic effects in electron transfer reactions at molecular scale
… concerning the cation specific effects: (1) indirect and (2) direct pathways. In indirect pathway, cations modify the extended hydrogen bonding structure of water in the solution; thereby, modifying the reorganization en- ergy associated with the electron transfer. In direct pathway, cations …
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Interpretation of and reasoning with conditionals : probabilities, mental models, and causality
… in a reasoning task. Additionally to this indirect pathway, the model contains a direct pathway: Cognitive availability of exceptional situations directly reduces the readiness to accept valid conclusions. The first experimental series tested the integrated model for conditional statements …
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
… feedforward loops in its central and peripheral pathways. The nociception system of the roundworm Caenorhabditis elegans shares many features of the mammalian circuit. Both neural circuits feature a direct path from sensory neurons to motor neurons that is connected by a single class of …
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