Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Dipeptidyl-peptidase 4"”.
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Dipeptidyl Peptidase-4 in Cariometabolic Disease
… cell specific expression of the serine protease dipeptidyl peptidase-4 (DPP4) were investigated in a series of murine models of metabolic dysfunction-associated steatotic liver disease (MASLD), cardiometabolic disease and myocardial infarction. In vivo experiments were conducted using several …
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HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS
… because they lack the expression of human dipeptidyl peptidase 4 (hDPP4), the functional viral entry receptor. To overcome this deficiency, we developed several lineages of transgenic (Tg) mice expressing hDPP4 globally by using the pCAGGS.MCS under the control of the CAG promoter, which is …
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Structural and Molecular Basis for Multifunctional Roles of Cellular Proteases
… of several critical cellular proteases (aminopeptidase A (APA), dipeptidyl peptidase 4 (DPP4), proprotein convertases (PPC) and lysosomal cysteine proteases (LCP)). APA is well known for its role in blood pressure regulation, but the lack of its structure is a major obstacle for designing …
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Determination of precipitated primary non-adherence after step therapy intervention in 4 classes of therapy
… blockers, uro-selective alpha-blockers, and dipeptidyl peptidase-4 inhibitors) in the Department of Defense. Using a retrospective database analysis, this study examined the primary adherence rate of subjects after they have been denied coverage due to Step Therapy intervention. Additionally, …
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Investigating senescence and senescence-escape in cancer cells
… with the investigation of a cell surface protein dipeptidyl-peptidase 4 (DPP4/CD26) as a potential marker of senescence in cancer, and the establishment of a treatment strategy exploiting TIS. Three different drugs were used to induce senescence in MCF-7 and MDA-MB-231 breast cancer cell lines, …
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Developing a Senomorphic Treatment Strategy in Osteoarthritis
… with OA disease severity, identified a biomarker dipeptidyl peptidase-4 (DPP4) for chondrocyte senescence and OA progression, and proposed a senomorphic treatment using chromobox 4 (CBX4) for modulating cell function of the replicative senescent model WI-38 cells and human osteoarthritic …
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The effectiveness of GLP-1 analogues compared to DPP-4 inhibitors for beta cell function and diabetes related complications among adults with type 2 diabetes: a systematic review and meta-analysis
… of incretin-based antihyperglycaemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1(GLP-1) analogues, have shown favourable effects on beta cell function. The aim of this systematic review was to provide a comprehensive synthesis of randomised clinical studies …
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Pre-, pro-, and synbiotic modulation of the intestinal microbiota stimulates enteroendocrine mediated intestinal adaptation in piglets with short-bowel syndrome
… ileum. Most notably, PRE decreased expression of Dipeptidyl-peptidase 4 (P = 0.0027). mRNA expression of secondary GLP-2 signaling elements was diminished by PRO in the colon. Treatments with scFOS (PRE and SYN) decreased abundance of bacterial species detrimental to GLP-2 signaling, including …
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Recurrent Hypoglycaemia-examining Impact and Strategy
… cross over trial, comparing Saxagliptin, a dipeptidyl peptidase 4 inhibitor (DPP4-I) that had been shown to known for its glucagon suppressive action, with placebo in a small cohort of subjects with Type 1 diabetes. However, we found that 12-weeks Saxagliptin therapy failed to have any …