Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Dipeptides"”.
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Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis
The H⁺ and Cu²⁺ equilibria of four glycine peptides (glycyl-glycine, glycyl-L-leucine, glycyl-L-phenylalanine and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode …
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OXYGEN-17 NUCLEAR MAGNETIC RESONANCE OF GLYCINE, ALANINE, DIPEPTIDES AND MELANOCYTE INHIBITING FACTOR (NMR).
… NUCLEAR MAGNETIC RESONANCE OF GLYCINE, ALANINE, DIPEPTIDES AND MELANOCYTE INHIBITING FACTOR (NMR).
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Tracing history of protein domain organization, functional loops, and dipeptides with chronologies and networks
This Dissertation was approved for publication on 2022-07-14 at 09:55.
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Isomerization-Locked Alkene Analogues of Xaa–Pro Dipeptides in the Proteins Collagen and Bora
… the importance of cis-trans isomerization. The dipeptides H–Ser–Ψ[(Z)CH=C]-Pro–OH, H–Ser–Ψ[(E)CH=C]-Pro–OH and native H–Ser–Pro–OH were synthesized by literature methods, and activated for aminoacylation of tRNACUA for in vitro transcription-translation. Aminoacylation by chemical methods …
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Toxic PRn Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Block Nuclear Import and Export
… manner to yield five distinct poly-dipeptides. Expression of either the glycine:arginine (GRn) or proline:arginine (PRn) poly-dipeptide in Drosophila leads to neurodegneration of the eye, and when introduced into culturing medium, synthetic forms of both peptides lead to the death of …
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Nutrition in relation to coremia and spore production in Penicillium clavigerum
… morphology. Coremia are produced only if certain dipeptides are added to the medium. The dipeptides shown to produce this response were DL-alpha aminobutyric acid-DL-leucine, DL-leucyl-DL-alanine, DL-alanylglycine, and glycyl-DLaspartic acid. No sporophores were produced in the absence of these …
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Transition-Metal Complexes as Enzyme-Like Reagents for Protein Cleavage
… of the amide bond in histidine-containing dipeptides, has been studied. Transition-metal complexes are emerging as new reagents for selective cleavage of unactivated amide bonds in proteins. Such complexes bind to the side chains of methionine and histidine forming an inert complex with the …
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The effect of leucine and dileucine ingestion on muscle protein turnover in healthy young men
… single amino acids, food proteins also contain dipeptides. Little is known, however, about the anabolic and catabolic effects of dipeptides, whose uptake rates have been shown to be faster than corresponding free amino acid. As such, uncovering how dipeptides impact muscle protein turnover is …
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Cloning, Sequencing and Expression of a Porcine Intestinal Peptide Transporter in a Mammalian Cell Line
… at a pH of 5.5-6.0. Eighteen different unlabeled dipeptides and tripeptides were found to inhibit the uptake of [3H] -Gly-Sar in competition studies. The IC50 of 13 of the dipeptides and two tripeptides ranged between 0.015 to 0.4 mmol/L. The exceptions were Lys-Lys, Arg-Lys, and Lys-Trp-Lys, …
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Molecular Cloning, In Vitro Expression, and Functional Characterization of an Ovine Gastrointestinal Peptide Transporter (oPepT1)
… specificity that transported neutral and charged dipeptides and tripeptides. All dipeptides and tripeptides examined evoked inward currents in a saturable manner, with an affinity constant (Kt) ranging from 20 mM to .6 mM for dipeptides and .15 to 3.0 mM for tripeptides. No responses were detected …
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The application of capillary electrophoresis and mass spectrometry to clinical and environmental problems
… (CE/ES). Clinically orientated analytes, dipeptides in urine and acylcamitines from blood spots were examined and peaks detected directly via uv absorbance. The environmental samples analysed included those which contained chromophoric or non-chromophoric herbicides as well as those …
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Design, synthesis, and analysis of conjugated activators for modulation of alternative splicing
… domains rich in highly charged arginine-serine dipeptides. Defects in alternative splicing have been linked to several diseases, including Cystic Fibrosis, breast cancer, and Spinal Muscular Atrophy (SMA). SMA is a neurodegenerative disorder caused by the loss of survival of motor neuron 1 …
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Chemical and Enzymatic Synthesis of Dehydropeptides and Their Fluoro Analogs
… an enzymatic fashion. For instance, fluorinated dipeptides, L-alanine-D-fluoroalanine and L-alanine- D,L-difluoroalanine were treated with the epimerase YcjG to produce L-Ala-Dha and L-Ala-Dha(F), respectively, as determined by 1H NMR, 19F NMR and MS (ESI).
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Investigating the modulation of oral drug absorption using in vitro models
Dipeptides can be absorbed into cells via the dipeptide transporter (which also transported tripeptides and dipeptide derivatives). The optimum conditions for measuring the inhibition of Gly-Pro uptake in Caco-2 cells were identified. A number of structure-activity relationships were identified. …
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The proteolytic activity of yoghurt and probiotic bacteria for the improved viability of probiotic bacteria in fermented milk products
… Dipeptidase activities were measured using dipeptides including Ala-Met, Leu-Tyr, Leu-Gly, Ala-His, and Pro-lLe as substrates. Endopeptidase and tripeptidase activities were detected using thin-layer chromatography.
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Assignment of Enzyme Function Through Characterization of the RuBisCO and Enolase Superfamilies
… with unique specificity for hydrophobic dipeptides through screening of dipeptide libraries by mass spectrometry followed by full kinetic characterization of individual dipeptide substrates. These results have provided additional evidence for the utility of multi-disciplinary approaches …
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Peptide Mediated Co-assembly of Porphyrin: Towards Sustainable Biomaterials for Light Harvesting and Catalysis
… ordered peptide nanostructures.</p> <p>Cyclic dipeptides are simple yet versatile molecules with customizable supramolecular properties, which are dictated by the functionality of their two amino acid side chains. Their self-assembly propensity has typically been investigated using cyclic …
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The Development of Sulfatase-Cleavable Linkers for Antibody-Drug Conjugates
… success of an ADC. Although cathepsin-cleavable dipeptides are the most widely used linker motifs, they suffer from a number of key drawbacks, such as instability in rodent blood and poor aqueous solubility. First, this thesis describes the design, synthesis and evaluation of arylsulfates as …
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Self-assembled Peptide Hydrogels for Therapeutic H2S Delivery
… H2S releasing APA hydrogels. The H2S-releasing dipeptides S-FE and S-YE formed self-assembled twisted nanoribbons and nanotubes, respectively. The non H2S-releasing control oxime dipeptides C-FE and C-YE were also synthesized. The C-FE formed nanoribbons while the C-YE only showed non-specific …
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Peptides as amino acid sources for the synthesis of secreted proteins by mammary tissue explants and cultured mammary epithelial cells
… of ³H-leucine promoted by some methiony] dipeptides was reduced (P < .05) in the presence of a 200-fold higher concentration of glycylsarcosine or carnosine. Incorporation of ³H-leucine promoted by lysyl peptides ranged from 91 to 117% of the incorporation promoted by free lysine. MAC-T …
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