Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 98 for “"Dipeptide"”.
-
Dipeptide nanotubes for biomedical applications
Ultrashort dipeptides based on the FF motif can self-assemble into discrete peptide nanotubes, which have been investigated over the last decade for their potential in the biomedical field. Understanding and controlling the variables which govern the self-assembly process is key to producing an …
-
A computational study of Trishomocubane amino acid dipeptide
A dissertation submitted in partial fulfilment of the requirements for the degree of Master of Technology: Chemistry, Durban Institute of Technology, Durban, South Africa, 2004.
-
Design and synthesis of substituted cyclopropanes as conformationally restrained dipeptide mimics
Molecular recognition plays a vital role in a wide variety of biochemical transformations. Of particular interest to chemists, biochemists, and biologists is the process by which enzymes recognize and bind substrates in the catalytic process. The relationship of peptide structure to properties and …
-
Synthesis of D-alanyl-D-alanine dipeptide isosteres and cephalosporin prodrugs
… growing peptidoglycan cell wall. Synthesis of dipeptide isosteres which may be incorporated into the growing cell wall is described. Previously published syntheses were employed as well as a Wittig reaction using a chiral Wittig reagent, a reaction not used in the synthesis of isosteres before. …
-
Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… ocular bio-availability of GCV. A series of dipeptide monoester prodrugs and amino acid monoester and diester prodrugs were designed to target the nutrient transporters peptide transporter (hPEPT1) and sodium dependent neutral and cationic transporter (B [super 0,+]), respectively. The …
-
Design and synthesis of constrained dipeptide units for use as β-sheet promoters
… synthetic organic chemistry methods, two dipeptide units are designed and synthesized that are constrained to form the extended conformation and mimic the hydrogen-bonding and side chain interactions that natural beta-sheets form along one edge of the individual peptide strands. …
-
Design and stereoselective synthesis of novel bicyclicbeta-turn dipeptide mimetics and cis-4-substitutedproline analogues for peptides and peptidomimetics
… were designed to serve as surrogates of the dipeptides Phe-Gly and Phe-Arg which contain two important pharmacophore elements in Leu-Enkephalin and melanotropin peptides, respectively. Introduction of side chain functionality at C-8 was achieved by using beta-substituted pyroglutamate as a …
-
Assignment of Enzyme Function Through Characterization of the RuBisCO and Enolase Superfamilies
… faecalis enzymes were subsequently confirmed as dipeptide epimerases with unique specificity for hydrophobic dipeptides through screening of dipeptide libraries by mass spectrometry followed by full kinetic characterization of individual dipeptide substrates. These results have provided …
-
A Nascent Peptide Code for Translational Control of mRNA Stability in Human Cells
… cells. We identify several families of simple dipeptide repeats whose translation triggers mRNA destabilization. Rather than individual amino acids, specific combinations of bulky and positively charged amino acids are critical for the destabilizing effects of dipeptide repeats. Remarkably, …
-
Determination of L- and D-methionine and L- and D-valine in soy isolate and soy flour samples
… were present this would produce diastereomeric dipeptide derivatives. The derivatives were separated by ion-exchange chromatography using a TSM Amino Acid Analyzer. Comparison of the sample methionine and valine dipeptide peaks to standard dipeptide peaks revealed the presence of L-valine, …
-
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
… oral bioavailability of SQV. Four stereoisomeric dipeptide prodrugs of SQV including L-valine-L-valine-SQV (LLS), L-valine-D-valine-SQV (LDS), D-valine-L-valine-SQV (DLS) and D-valine-Dvaline- SQV (DDS) and two amino acid prodrugs including L-valine-SQV (LS) and Dvaline- SQV (DS) were synthesized …
-
Absorption of carnosine and methionylglycine by sheep ruminal and omasal epithelia
… over a 240-min incubation. The quantity of dipeptide absorbed or transferred was linearly (P < .01) dependent on substrate concentration. Carnosine was transferred intact across both tissues. More carnosine was absorbed (P < .02) and transferred (P < .01) by the omasal epithelia. …
-
The Role of Small Peptides in Cancer Physiology and Chemotherapy
… to mouse Ehrlich ascites tumor cells. The dipeptide beta-alanyl-melphalan was synthesized and tested in vitro for toxicity towards mouse Ehrlich ascites tumor cells, mouse liver cells, and mouse 3T3 embryonic cells. The parent compound, melphalan, was used as a control treatment. In …
-
Carnosine’s inhibitory effect on glioblastoma cell growth is independent of its cleavage
As one of several imidazole-containing dipeptides, carnosine is found primarily in the skeletal muscle, the brain, the olfactory bulb and the kidneys of mammals, fishes and birds. The enzyme Carnosine Synthase 1 regulates its synthesis and the two enzymes responsible for the dipeptide’s cleavage …
-
Diphenylalanine self-assembly- kinetics, thermodynamics and its relevance to amyloidogenesis
Diphenylalanine (FF) is a dipeptide capable of self-assembly in aqueous solution into needle-like hollow micro- and nanocrystals that possess advantageous properties such as high stiffness and piezoelectricity and have emerged as attractive candidates for functional nanomaterials. In addition, …
-
Advancing Normalising Flows to Model Boltzmann Distributions
… Boltzmann distribution of the molecule alanine dipeptide more closely. Thirdly, normalising flows are made more expressive by the introduction of a novel base distribution. It alters the topology of the base distribution via rejection sampling with a learnt acceptance function. Thereby, we …
-
Total synthesis of a virotoxin and analogs for conformational studies
… herein an efficient strategy that provides a dipeptide containing a (2S,4S)-4,5-dihydroxyleucine (dihyLeu) residue, including a diastereoselective dihydroxylation. Nα-Carbobenzyloxy-(2S)-4,5-dehydroleucine was coupled with valine ethyl ester to give a dipeptide that was subjected to a …
-
Synthetic studies of luzopeptins
… in conjunction with the formation of PCA-serine dipeptide derivatives, 164. All these methodologies were successfully applied to the synthesis of monomeric derivative of luzopeptin E$\sb2,$ 288.* ftn*Please refer to the dissertation for diagram.
-
Toxic PRn Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Block Nuclear Import and Export
… manner to yield five distinct poly-dipeptides. Expression of either the glycine:arginine (GRn) or proline:arginine (PRn) poly-dipeptide in Drosophila leads to neurodegneration of the eye, and when introduced into culturing medium, synthetic forms of both peptides lead to the death of …
Page 1 of 5