Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Dioxin"”.
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The influence of environmental justice on the dioxin controversy
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1996.
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Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for its immunotoxic effects, particularly on the thymus. The exact mechanism by which TCDD induces thymic atrophy is not known. In the current study, we investigated whether TCDD triggers …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
Developmental 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure can permanently alter immune system ontogeny, resulting in the dysregulation of a number of vital immune pathways. We hypothesized that developmental exposure to TCDD may also impair the establishment of self-tolerance, resulting in …
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Role of Aryl Hydrocarbon Receptor in Circadian Rhythm: A Novel Pathway to Dioxin Toxicity
… such as 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD). However, a physiological role of AhR remains unknown. Many members of PAS domain family play a role in regulation of circadian rhythm; therefore the role of AhR in the circadian rhythm was investigated. First, to examine AhR as a …
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD) is a potent teratogen that impacts the developing cardiovascular system. Hallmarks of embryonic exposure include cardiac malformation, impaired circulation, loss of erythrocytes, pericardial and yolk sac edema, and early life stage mortality. However, the …
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Embryotoxicity of dioxin-like chemicals extracted from American eels (Anguilla rostrata) from the St. Lawrence River System
… may be acting cumulatively. Maternally derived dioxin-like contaminants (DLCs) accumulated during the growth phase of eels in Lake Ontario are toxic to fish embryos, and embryotoxicity is expressed as a series of malformations known as blue sac disease (BSD). I assessed whether these toxicants …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… (DES) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been identified as immunotoxicants causing thymic atrophy, thymocyte hypocellularity, phenotypic changes detected by CD4 and CD8 surface antigens, and progenitor T-cell targeting in the fetal mouse. We hypothesized that …
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The Effects of Lactational and Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Spatial Learning and Memory
One way in which rats are able to solve the RAM without employing memory systems is by using a response strategy. The most obvious response strategy that would yield better performance on the RAM is adjacent arm selection. A final study was conducted, in which TCDD-exposed animals were tested on …
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Effects of Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Reproductive Development and Sexually Dimorphic Behaviors in Rats
In contrast sexually dimorphic non-reproductive behaviors were affected in TCDD and coplanar PCB exposed rats. In the initial study, the play behavior in TCDD exposed rats was suppressed. However in the follow-up study, when play behavior was tested with a different protocol than in the initial …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity. </p> <p>Previous studies suggested that dioxin exposure increased peripheral insulin …
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Phase Speciation of Carbohydrates and Dioxins in Rivers and Coastal Waters in the Northern Gulf of Mexico
… a salinity gradient. The phase partitioning of dioxin among three different phases, i.e., colloidal organic matter, particulate organic matter and sediments, was also determined for Mississippi River and Pearl samples. MCHO was the dominant species in the dissolved CHO, with high concentrations …
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Sorption mechanisms of dibenzo-p-dioxin/furan from water by smectite clays and theoretical studies on formation pathways of chlorodibenzo-p-dioxins from precursor chlorophenols on smectite clays
… minerals may be an important sorptive phase for dioxins in soils, and dioxins are often found in natural clay deposits. Sorption experiments demonstrated that smectites, especially Cs-saponite, effectively adsorbed dibenzo-p-dioxin /furan from water. Adsorption was promoted by exchangeable …
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A Rhapsody on the Aryl Hydrocarbon Receptor: Molecular and Environmental Health Insights Through Novel and Canonical Signaling Pathways
… most notably 2,3,7,8-tetrechlorodibenzo-p-dioxin. In this role, the AhR is known to play a fundamental role in several physiological process, for example cell division. Pathologically, the AhR has been identified as a fundamental driver of the toxic effects of numerous persistent, potent, …
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Assessment of dietary background exposure of the Irish adult population to dioxins and PCBs particularly taking into account additional exposure due to the 2008 Irish dioxin food contamination incident
… dietary background exposure of Irish adults to dioxins and PCBs. Furthermore, all available information on the 2008 Irish pork dioxin food contamination incident was collated and analysed with a view to evaluate any potential impact the incident may have had on general dioxin and PCB background …
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Quality and safety of oils and fats obtained as co-products or by-products of the food chain and destined to animal production
… acid distillate), environmental contaminants (dioxins and PCBs) (two different fish oils), PAH (olive oil acid oils and pomace olive oil from chemical refining, for low and high levels) and oxidation products (sunflower-olive oil blend before and after frying), so as to obtain single feedings …
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A Modified Procedure for the Synthesis of Bis(phenylenedioxy)tetrathiafulvalene (BPDO-TTF): an Electron Donor for Charge Transfer Organic Complexes.
… worked out scheme. 2,3-Dihydrobenzo-1, 4-dioxin<em><strong>(1)</strong></em> was synthesized from catechol in a strongly alkaline medium. Compound <em><strong>(1)</strong></em> was dichlorinated with SO<sub>2</sub>Cl<sub>2</sub> to give 2,3-dichloro-2,3-dihydrobenzo-1,4-dioxin …
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Comparative analyses of aryl hydrocarbon receptor structure and function in marine mammals
… organic pollutants, including PCBs and dioxin-like compounds (DLC). Chronic environmental or dietary exposure to these chemicals can disrupt the function of reproductive and immune systems, as well as cause developmental defects in laboratory animals. The aryl hydrocarbon receptor (AHR) …
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Use of the Immune System to Investigate the Toxicity Induced by Environmental Pollutants in Fish, Amphibian, and Mammalian Species
… exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), commonly referred to as dioxin, a highly toxic environmental pollutant, was tested in C57BL/6 mice. TCDD was administered on gestational day 14 and pup thymocytes were studied for apoptosis on postnatal days 2, 4, 7, 14, and 21. …
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