Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Dimethyl Fumarate"”.
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Development of a novel combination radio- chemotherapy for glioblastoma multiforme
… more efficacious treatment options are needed. Dimethyl fumarate is a clinically available immunomodulatory drug, currently used to treat multiple sclerosis.;One of the targets of dimethyl fumarate is glutathione, a potent chemo- and radio-resistance factor. We hypothesised that the use of …
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Fumarate Inhibits TNF-α Release
… derivatives of a citric acid cycle intermediate, fumarate, as potential mediators of endotoxin-induced TNF-α release. We determined that 10µM dimethyl fumarate (DMF) significantly inhibited LPS-mediated soluble TNF-α released from the mouse monocyte cell line RAW 264.7, with no effect on cell …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… inducers, including the CNS-penetrating drug dimethyl fumarate (DMF), decreased supernatant glutamate and neurotoxicity. These findings identify HO-1 as a host factor that is deficient in the brains of HIV-infected individuals and suggest that loss of HO-1 and its protective functions may …
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Investigating the role of mitochondrial dysfunction in a Drosophila model of C9orf72 ALS/FTD
… treatment with an NRF2 activator, dimethyl fumarate (DMF), showed a behavioural rescue in climbing activity of G4C2x36 and GR36 flies. While more research is needed, these results provide compelling evidence that mitochondrial oxidative stress is a major upstream pathogenic …