Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Dimerizer"”.
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Advancements in genome engineering and applications in mammalian systems
… aureus (dCas9Sa) with chemically inducible dimerizers GAI-GID, FKBP-FRB and ABI-PYL1 respectively. The dCas9 protein was fused with one of the dimerizers and the other dimerizer was fused with activator domain p65-HSF1. Addition of inducers enabled dimerization which resulted in the …
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Toward therapeutic nanoassemblies: the design and modeling of protein-protein interactions.
… configurational treatment of the complex bis-MTX dimerizer. While initial attempts at calculating the binding free energy of the macromolecular complex have been unsuccessful, we have gleaned important insights into the complexities of modeling this three-body system. The advances described within …
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Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan
… of RTKs involves membrane tethering of dimerizer-RTK ICD fusions. Depending on the intrinsic signaling capacity, however, this approach could entail undesirable baseline signaling activity in the absence of stimulus, thereby diminishing the system's sensitivity. To surpass this …
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Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
… D123neg tumor cells. The addition of a chemical dimerizer to activate iCaspase9 resulted in destruction of genetically modified T cells. Both populations of CAR+ T cells produced and eliminated leukemic tumors <em>i</em><em>n vivo. </em>We observed no difference in the anti-tumor effects whether …