Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 337 for “"Dimerization"”.
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The Rev-mediated Dimerization of HIV RRE RNA
The HIV-1 Regulator of Virion Expression (Rev) a regulatory protein which is critical for the late-phase development of the Human Immunodeficiency Virus-1 (HIV-1). During early-phase development of HIV-1, Rev accumulates in the cytoplasm and is transported into the nucleus through interactions with …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
… this thesis focused on targeting the homodimerization of the EGF receptors themselves and the heterodimerization of EGF receptors with the related ErbB2 receptor. Three sub-projects were completed in the process. The first project explored the feasibility of inhibiting the EGF receptor by …
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Hiv-1 Rna Dimerization At Single Molecule Level
<p>The Dimerization Initiation Sequence (DIS) is a conserved hairpin-loop motif on the 5' UTR of the HIV-1 genome. It plays an important role in genome dimerization through formation of a "kissing complex" intermediate between two homologous DIS sequences. This bimolecular kissing complex …
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The Rev-mediated Dimerization of HIV RRE RNA
The HIV-1 Regulator of Virion Expression (Rev) a regulatory protein which is critical for the late-phase development of the Human Immunodeficiency Virus-1 (HIV-1). During early-phase development of HIV-1, Rev accumulates in the cytoplasm and is transported into the nucleus through interactions with …
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Nickel Reduces Calcium Dependent Dimerization In Neural Cadherin
… divalent cations might affect calciumdependent dimerization of neural-(N-) cadherin. The first chapter focuses on studies to characterize the impact of binding physiological magnesium (II) or neurotoxic nickel (II) on calcium-dependent N-cadherin function. Physiological levels of magnesium have …
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Highly Efficient Catalysts for the Dimerization of α-Olefins
The aim of my work was the catalytic dimerization of a-olefins, especially the dimerization of propylene. The focus was laid on the optimization of product selectivity, catalyst lifetime, and product separation. Previous studies in our group have shown the enormous potential of bis(imino)pyridin …
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Mechanism of E-cadherin dimerization at the plasma membrane
Embargo set by: Seth Robbins for item 118623 Lift date: 2023-09-17T04:04:53Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… sequences and structures that are involved in dimerization and packaging of HIV-2 RNA. Progressing from previous findings, we studied in detail a 10-nucleotide palindrome sequence (pal; 5'-GGAGUGCUCC-3') of the 5'UTR, located within the major packaging signal, upstream of the dimerization …
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… sequences and structures that are involved in dimerization and packaging of HIV-2 RNA. Progressing from previous findings, we studied in detail a 10-nucleotide palindrome sequence (pal; 5'-GGAGUGCUCC-3') of the 5'UTR, located within the major packaging signal, upstream of the dimerization …
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Selective ethylene dimerization by a nickel-exchanged metal-organic framework catalyst
… systems are used to catalyze ethylene dimerization in industry, causing many to suffer from quick deactivation and poor selectivity. The metal-organic framework (MOF) CPF-5 Mn₅(TBA)₃(HCOO)₃(OH)(H₂O₂)2]]₄·6DMF where TBA = 4-(l H-tetrazol-5-yl)benzoic acid provides an ideal structural …
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Development of chemical inducers of dimerization for screening competitive histone deactelyase inhibitors
<p>Histone Deacetylase (HDAC) proteins are transcriptional regulators that affect histone proteins, which are involved in packaging of DNA into chromosomes. HDACs have been linked to the proliferation of cancer through their role in transcriptional regulation. Due to these findings, HDAC inhibitors …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
… factor (EGF) binding and EGF receptor (EGFR) dimerization are not as well understood. Due to the large disparity of time and length scales involved in receptor dimerization reactions, we adapt the coarse-grained Monte Carlo (CGMC) simulation framework to enable the simulation of in vivo …
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Contribution of specific amino acids to calcium-dependent dimerization of epithelial cadherin
… of cadherin dimers through strand-swapped dimerization between two interacting protomers from adherent cells. Recently, a number of studies of dimer formation of E-cadherin supported a two-step adhesive binding model. First, an inter-molecular initial encounter complex (X-dimer) forms at …
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I. Direct observation of o-xylylene (o-quinodimethane) in solution, Dimerization kinetics of some o-quinodimethanes; II. Kinetic and product studies on the dimerization of [alpha]-methyl-substituted o-quinodimethanes; III. Direct observation of 1,2-napthoquinodimethane and 9,10-phenanthroquinodimethane, Dimerization kinetics of resonance-stabilized o-quinodimethanes
… spectroscopy it was determined that the dimerization of 1 follows second-order kinetics with a rate constant of 9.94 (+OR-) 0.32 x 10('3) L mol('-1) sec('-1) at 25(DEGREES)C in CH(,3)CN. Two ring-alkylated derivatives of 1, 4-t-butyl-1,2-xylylene (28) and …
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Localization and dimerization of the ABC half transporter rAbcb6 as compared to rAbcb7
Abcb6 (rAbcb6) ist ein ABC-Halbtransporter der ABCB-Subfamilie und benötigt einen Dimerisationspartner, um seine Funktion ausüben zu können. Das Hauptziel dieser Arbeit war die Identifizierung eines Dimerisationspartners für rAbcb6. Aufgrund der Sequenzhomologie zwischen menschlichem ABCB7 und …
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Role of Dimerization in Binding of Estrogen Receptor to the Estrogen Response Element
I investigated the role of dimerization in the binding of estrogen receptor to estrogen response elements. I found that the affinity of the estrogen receptor for the consensus estrogen response element is increased by six- to ten-fold by dimerization. This observation was true for both full length …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
… unknown. To address this problem, a potential dimerization interface of the prototypical GPCR, rhodopsin, was analyzed using a proteomics approach involving chemical crosslinking and liquid chromatography-mass spectrometry. The strategy was devised so that rhodopsin could be probed in the …
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Characterization of the Dimerization and Salt Dependent Aggregation of the ALS-Linked Protein TDP-43
… indicate that TDP-43 can form head-to-tail dimerization between two N-terminal domains (NTD) and head-to-head dimerization between two RNA-recognition motifs 2 (RRM2). When both interfaces are disrupted, we isolate a tentatively assigned monomeric species. The second aim of our study was to …
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