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Showing 1 to 11 of 11 for “"Diketopiperazines."”.
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Experimental and theoretical vibrational spectroscopic studies of diketopiperazines
The diketopiperazine (DKP) cyclo(L-homoCySH-L-homoCySH) (C-CySH) has been synthesised by a method reported in the literature. DFT calculations of molecular structures and their associated vibrational modes were conducted at the B3LYP/aug-cc-pVTZ level. The two calculated minimum energy structures …
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DESIGN, SYNTHESIS, AND CHARACTERIZATION OF INDANE 2,5-DIKETOPIPERAZINES FOR LIQUID CRYSTAL APPLICATIONS
Non-covalent interactions are of great importance in biology, chemistry, and material sciences. Although much information about different types of non-covalent interactions is available, incorporating them in a molecular design to generate a molecule that can undergo association to form a molecular …
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Development and application of new strategies for synthesis of complex diketopiperazine alkaloids
… permanganate promoted hydroxylation of diketopiperazines has served as a pivotal transformation in the synthesis of complex epipolythiodiketopiperazine alkaloids. This late-stage C-H oxidation chemistry is strategically critical to access N-acyl iminium ion intermediates necessary for …
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Total synthesis of cyclotryptamine and diketopiperazine alkaloids and biosynthetic pathway investigation of unsymmetrical diketopiperazine dimers
… Pathway The biogenesis of unsymmetrical dimeric diketopiperazines is investigated, in collaboration with the Sherman group at the University of Michigan. Sequencing and mining the genome of Streptomyces sp. CB MQ-030, known to produce unsymmetrical diketopiperazine dimers, allowed the …
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Total synthesis of cyclotryptamine and diketopiperazine alkaloids
… natural products. Although the dimeric epidithiodiketopiperazines have been known for nearly four decades, none has succumbed to total synthesis. We report a concise enantioselective total synthesis of (+)- 12,12'-dideoxyverticillin A via a strategy inspired by our biosynthetic hypothesis for …
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Geographic and Host-Microbe Symbiotic Influence on Secondary Metabolism
… of broad spectrum bioactive molecules known as diketopiperazines. Previous research suggests that these compounds possess bioactivities that can benefit the sponge in a symbiotic relationship, including growth promoter and antifouling properties. Screening of the crude extracts revealed the …
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Studies on stereospecific diketopiperazine oxidation and applications to the synthesis of complex epidithiodiketopiperazines
I. Introduction and Background on Epidithiodiketopiperazines A brief history and summary of methods for synthesis of epidithiodiketopiperazines (ETPs) are discussed. Three hypotheses for the mechanism of action of these biologically active natural products are reviewed, and the unified biosynthetic …
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Generation of Biomarkers from Anthrax Spores by Catalysis and Analytical Pyrolysis
… acid, picolinic acid, propionamide, acetamide, diketopiperazines, fatty acids, furfuryl alcohol, and DNA bases. A statistically designed factorial study was used to determine the importance of temperature, spore loading, and nanocluster loading on the production of three important biomarkers. …
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Studies on organic electron donors and their applications in chemistry
… process.;Chapter Two highlights the ability of diketopiperazines 1-4 to promote the cross-coupling reactions of aryl halides 5-16 with benzene in the presence of potassium tert-butoxide 17 to form biaryls 18-24 via electron transfer [graphic of electron transfer process].;It also investigates …
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Total syntheses of (±)-dracephalone A and (±)-dracocequinones A and B, progress towards a total synthesis of cassiabudanols A and B, and synthetic studies towards total synthesis of N-oxy-diketopiperazine containing natural products.
… of the tricyclic core of [2.2.3]-Epidithiodiketopiperazines is described. The key step features a diastereoselective intramolecular NDA reaction of the cyclopentadiene adduct intermediate derived from (-)-quinic acid. Attempts to install the tertiary alcohol via a diastereoselective …