Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Dihydrotestosterone"”.
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Synthesis and androgen receptor binding of novel derivatives of dihydrotestosterone
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effects of 5��-Dihydrotestosterone (DHT) on Mouse Gut Microbiome– A Study of Sex Differences and Hormonal Effects on Gut Microbiome Composition
… (NOD) mice implanted with slow release 5��-Dihydrotestosterone(DHT) for 90 days showed improved glucose tolerance when compared to untreated females. We hypothesized that DHT treatment alters female gut microbial profile to resemble a male-like gut microbiome that induces improved glucose …
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Význam androgenů adrenálního původu u syndromu polycystických ovarií a hirsutismu
… - 11-oxygenated derivatives of testosterone and dihydrotestosterone. Besides their high androgenic potency, their relatively high levels in circulation prompt attention to be paid to these steroid hormones in all endocrine disorders where classical androgens are monitored. The determination of …
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The role of sex steroids in the regulation of the Obese gene and leptin secretion
… line (3T3-L1) was treated with 17β-estradiol and dihydrotestosterone and RNA was harvested for analysis by qRT-PCR. Media extracts were also collected for leptin ELISA. The present study suggests a weak stimulation of Obese mRNA accumulation by estrogen that parallels the accumulation of Resistin …
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Temporal profile of gonadal steroids in populations of roosters divergently selected for mating frequency
… activity. Plasma levels of androstenedione (AE), dihydrotestosterone (DHT), testosterone (T), total androgens (Total A) and estradiol-17<sub>β</sub> (E₂) were measured at 1, 56, 112 and 168 days of age by radioimmunoassay. No significant differences in mean hormone values were found between the …
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Neural and endocrine control of mating behavior in selected mating lines of chickens and quail
… in two different testing situations, whereas dihydrotestosterone was ineffective in this respect. In the LML quail, only EB was effective in eliciting mating behavior, and then only in the mating situation where aggressive behavior was not prerequisite (i.e. with a female model). This …
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Regulation of Expression of 5 Alpha-Reductase Type 1 in Mouse Leydig Cells
… converts circulating testosterone to dihydrotestosterone in target tissues, a process that is necessary for development of the male phenotype in human beings. However, in some animals, androstanediol, a 5a-reduced androgen, is the primary androgen produced by the testis during certain …
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Modeling the Psychiatric Aspects of Polycystic Ovary Syndrome and Induced Stress
… Modeling PCOS in mice via administration of dihydrotestosterone (DHT) results in physiological alterations that are consistent with the physiological symptoms of PCOS in women. While some studies have investigated behavioral changes in PCOS mouse models, findings have varied. Thus, the …
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Computational Molecular Docking Models and Design of Diarylpentanoids for the Androgen Receptor
… family that, upon binding to its natural ligand dihydrotestosterone (DHT) in the cytoplasm, translocates to the nucleus and exerts nuclear transcription factor activity to drive gene expression related to normal prostate development. AR signaling becomes overactive during the development and …
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The Effects of Induced Polycystic Ovary Syndrome in NAG-1 Transgenic Mice
… To test this question, we induced PCOS via dihydrotestosterone (DHT) implantation in transgenic mice expressing the human NAG-1 gene. Our findings suggest that NAG-1 mice have similar physiological responses to DHT-treatment as compared to wild-type mice throughout the 90-day study. …
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Influence of Cellular Localization on Activity of Hydroxysteroid Dehydrogenases
… family; AKR1C9 catalyzes the reduction of dihydrotestosterone to androstanediol. These two enzymes provide a basis for comparative studies with 11beta-HSD1, which catalyzes the reduction of cortisone to cortisol. Most mammalian cells supplied with adequate glucose and oxygen maintain …
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The Role of 5-Alpha Reductase 3 In Steroid Metabolism
… to the more potent androgen, 5-alpha dihydrotestosterone (DHT), which is capable of binding the androgen receptor to activate gene targets and downstream signaling. This study aimed to evaluate the role of 5-alpha reductase 3 (SRD5A3), a novel member of the 5-alpha reductase family, in …
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Gonadal steroid regulation of luteinizing hormone-releasing hormone and luteinizing hormone release in the male sheep
… (T) and its metabolites, estradiol (E) and dihydrotestosterone (DHT) in the regulation of LH release in male sheep. The first four studies examined the ability of T, E or DHT to inhibit LH release, and the sites at which they exert their effects. The final study examined the role of T in …
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Androgen aromatization and cytosol estradiol-receptors in the mediation of masculine sexual behavior in Japanese quail
… brain tissues was in the form of testosterone, dihydrotestosterone, or estradiol. Neither the total ³H nor ³H-testosterone metabolite radioactivity differed upon comparison of the two genetic lines. Of all ³H-testosterone metabolite radioactivity, ³H-estradiol represented 45 ± 6% in the HM line …
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Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats
… (GDX) and given implants of testosterone, dihydrotestosterone (DHT), or empty, control implants (CTL) and plasma was obtained after 30 minutes of restraint. Although no significant differences were obtained for CORT levels, the pattern of means was consistent with our previous findings. …
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Comparison of human and mouse AKR1C enzymes: implications for modeling human cancer
… of the key steroids androstenedione, 5\(\alpha\)-dihydrotestosterone, progesterone and estrone was performed by 4 of the murine isoforms. However, unlike humans, no AKR1C isoforms were detected in murine prostate, testes, uterus and haemopoietic progenitors. This study exposes significant lack of …
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Effects of lower- and higher- volume resistance exercise on serum testosterone and skeletal muscle androgen receptor content in men : subsequent effects on the mRNA expression of insulin- like growth factor peptide and myostatin in skeletal muscle.
… elevations in skeletal muscle testosterone, 5α-dihydrotestosterone (DHT), androgen receptor mRNA and protein content as well as possible interactions between muscle IGF-1 and myostatin mRNA expression. In a randomized cross-over design, venous blood was obtained in male participants immediately …
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Lycopene, Selenium, Vitamin E and Prostate Cancer
… not significantly alter serum testosterone or dihydrotestosterone levels, tumor proliferation, or apoptosis rates. Finally using Real-Time PCR we wanted to examine whether alterations in androgen gene (androgen receptor, probasin) and/or selenium-associated protein genes (selenium binding …
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Measurement and risk assessment of endocrine disruptors present in sport supplements
… of EDs detected(equivalent to 17p-estradiol and dihydrotestosterone) in the sport supplements were also compared with the acceptable daily intake (ADI) of these hormones and the amount of hormones that people are exposed to via food and water.<br/><br/>Finally, estrogenic EDs were divided into …
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… Huh7-AR cells, which were responsive to 5 alpha-dihydrotestosterone (DHT), revealed a decreased tumorigenecity in nude mice in addition to reduced clonogenicity in vitro, as compared with those of Huh7-V cells; Tumor volume and multiplicity of the HCC development in nude mice and invasiveness of …
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