Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Dihydropteroate Synthase"”.
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Structural and Kinetics Studies of the Enzyme Dihydropteroate Synthase and the Implications for Antibiotic Resistance
… agents and act by targeting the enzyme dihydropteroate synthase (DHPS) of the prokaryotic and lower eukaryotic folate pathway.</p> <p>DHPS is an ideal drug target because humans do not synthesize folate de novo and is a well validated system. However, the emergence of bacterial …
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Herbicide Mediated Selection of Sulfonamide Resistant E. coli
… of asulam with the target protein of sulfas, dihydropteroate synthase (DHPS). ITC confirmed asulam interacts with DHPS, and in vitro directed evolution experiments showed that prolonged asulam exposure can select for sulfa-insensitive DHPS in E. coli. Since mobile sul genes also encode for …
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Study of the Cryptosporidium parvum DHFR-TS in the model system Saccharomyces cerevisiae
… DHFR-TS (dihydrofolate reductase-thymidylate synthase) enzyme and an engineered monofunctional DHFR domain alone. Yeast reliant on the DHFR-TS form show the expected synergy between trimetrexate, a DHFR inhibitor, and sulfanilamide, an inhibitor of dihydropteroate synthase (DHPS), another …
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
… to various mutations in the sulfonamide target dihydropteroate synthase. This information currently guides the development of next-generation antifolates designed to avoid these characterized resistance strategies. In the subsequent chapter, a conditional metabolic screening approach was …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… of tubulin polymerization or thymidylate synthase as well as for inhibition of one or more of the receptor tyrosine kinases (RTKs)- vascular endothelial growth factor receptor-2 (VEGFR2), epidermal growth factor receptor (EGFR) and/or platelet-derived growth factor receptor β (PDGFR- β) in …
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Structure- and Ligand-Based Design of Novel Antimicrobial Agents
… efforts to design novel inhibitors of the enzyme dihydropteroate synthase from <em>B. anthracis</em> using crystal structures with known inhibitors bound. The second part describes a QSAR study that was performed using a series of novel nitrofuranyl compounds with known, whole-cell, inhibitory …
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Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection
… of resistant strains expressing mutated dihydropteroate synthase enzyme (target of SMX). For patients unresponsive or resistant to this treatment, newer drugs are critically needed. The absence of an X-ray crystal structure of pjDHFR poses a large gap in drug discovery efforts. The status …