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Showing 1 to 8 of 8 for “"Dihydronaphthalene."”.
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Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
… analogs bearing key features of CA4 on a dihydronaphthalene framework: Oxi 6196 and a beta-dihydronaphthalene analog. In addition to VDAs, another class of exciting anticancer drugs is bioreductive agents that are selectively targeted towards the hypoxic region of tumors. These compounds …
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Conformational Analysis of 1-Tertiarybutyl-1, 4-Dihydronaphthalene a Turnover from SRNI to SNI Mechanism
… cyclohexadiene porition of 1-tertiarybutyl-1, 4-dihydronaphthalene exists in a puckered rather than planar conformation at room temperature, with approximately equal populations of the isomer with the t-butyl group “axial” and “equatorial.” Analysis of chemical shifts and coupling constants was …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… of a myriad of analogues and derivatives. Two dihydronaphthalene-based agents (KGP03 and KGP413) and their corresponding phosphate prodrug salts (KGP04 and KGP152), previously discovered by the Pinney Research Group (Baylor University), function as promising VDAs. These molecules provided …
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Applications of Hypervalent Iodine Reagents: From Enantioselective Copper-Catalysed Arylation-Semipinacol Cascade to Methionine Functionalisation for Peptide Macrocyclisation
… classes – including dihydropyran, indene and dihydronaphthalene moieties – are converted to enantioenriched beta-aryl spirocyclic ketones in excellent yields and enantioselectivities, and often as a single diastereomer. These are in turn useful functional handles for transformations into other …
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Studies of dichloro- and tetrachloro- adducts of naphthalene and some of its substituted derivatives
trans-1,2-Dichloro-1,2-dihydronaphthalene has been obtained as the major product of the photochlorination of naphthalene at low temperature, and is the first authentically described naphthalene dichloride. Its further reaction with chlorine, under heterolytic conditions gives, in part, a new …
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Asymmetric hydrogenation of unfunctionalized trisubstituted and tetrasubstituted olefins
… olefins. Hydrogenations of l ,2- dimethyi-3,4-dihydronaphthalene proceeded with high enantioselectivity, but were accompanied by side reactions. At 80 - 2000 psig H2, hydrogenations of a number of fully substituted unfunctionalized indenes proceeded cleanly to give mostly cis products with ee's …
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Design and synthesis of benzosuberene and tetracyclic-based molecules inspired by natural products as inhibitors of tubulin polymerization and preparation of drug-linker constructs to facilitate tumor selective targeted delivery.
… of bioactive molecules with benzosuberene, dihydronaphthalene, and indole-based molecular scaffolds as representative examples. Many of these compounds have demonstrated highly potent activity as both inhibitors of tubulin polymerization and cytotoxins. A subset of these molecules function …
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Observation by flow 1H NMR and dimerization kinetics and products of reactive ortho-quinodimethanes and benzocyclobutadiene
… reactive o-quinodimethanes, 1,2-dimethylene-1,2-dihydronaphthalene (9) and o-xylylene (1) were observed by flow [superscript]1H NMR spectroscopy at room temperature. The [superscript]1H NMR spectrum of 9, generated in acetonitrile-d[subscript]3 (CD[subscript]3CN) by fluoride ion induced …