Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Dihydroartemisinin"”.
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Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia
… discovered that a well known antimalarial drug dihydroartemisinin (DHA) killed host-IL7-protected BCR-ABLWT, c-MYC-overexpressing BCR-ABLWT and BCR-ABLMUTANT Ph+ ALL cells in vitro. In vivo, DHA displayed weak activity as a single agent but its addition synergistically augmented the leukemia …
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Development of liquid chromatography mass spectrometry methods for the monitoring of ropivacaine, endogenous steroids and dihydroartemisinin
The thesis consists of five chapters. The first chapter is general introduction to LC-MS, separation technology and extraction methods. The second chapter describes the development of a method to measure free and bound ropivacaine in human plasma using equilibrium dialysis and HILIC chromatography …
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An investigation into the molecular mechanisms induced by derivatives of natural products in oesophageal cancer
… artemisinin derivatives (artesunate and dihydroartemisinin), together with novel artemisinin hybrid compounds, as cancer chemotherapeutic agents and explored the mechanism of action in oesophageal cancer. Artesunate and dihydroartemisinin including seventeen other artemisinin derivatives …
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Effect of dihydroartemisin-piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV
… intermittent preventive treatment (IPTp). Dihydroartemisinin-piperaquine has been identified as a promising alternative to sulfadoxine-pyrimethamine for malaria prevention in pregnancy. However, another antimalarial drug, artesunate-amodiaquine, similar to dihydroartemisininpiperaquine, was …
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Novel Antimalarial and Antitubercular Agents Based on Natural Products
… and isatin-chalcone hybrids, and (iii) dihydroartemisinin-isatin, dihydroartemisinin-chalcones and other miscellaneous hybrids. These were evaluated for antiplasmodial activity against the chloroquine resistant (W2) and chloroquine sensitive (D10) strains of Plasmodium falciparum as well …
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… agents ABT-199 and ABT-263. The anti-malarial, dihydroartemisinin (DHA) translationally represses MCL-1 and synergizes with BH3-mimetics. To explore how DHA represses MCL-1, a genome-wide CRISPR screen identified that loss of genes in the heme synthesis pathway renders mouse BCR-ABL+ B-ALL cells …
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Changing Antimalarial Drug Sensitivities in Uganda
<p>Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment and prevention of malaria in Uganda. However, resistance to both components of this regimen has emerged in Southeast Asia. The efficacy of artemether-lumefantrine, the first-line regimen to treat malaria in …
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The efficacy and safety of artesunate suppositories in combination with other antimalarials in the treatment of severe malaria in Sudan.
… and quantification of artesunate, alpha and beta dihydroartemisinin and artemisinin in pooled plasma. Difficulties encountered in the analysis of the Sudanese subject plasma samples were overcome by developing alternative chromatographic methodology. An ion-pairing HPLC method was developed which …
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Anti-malaria drug treatment in Vietnam
… thesis. The conclusion is<br></br><br></br> 1/ Dihydroartemisinin-piperaquine is an inexpensive, safe, highly efficacious fixeddose antimalarial combination treatment that could make an important contribution to the control of multidrug-resistant fa1ciparum malaria for Vietnan1 and other …
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Lipid & surfactant based systems for improved delivery of poorly soluble APIs
… study, the handling and oral bioavailability of dihydroartemisinin dimer oxime was studied using various lipid based systems for potential use in the treatment of malaria.</p> <p>The lipid based tablet formulation of Δ9-THC was successful in achieving a 24 hour release profile and can be …
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Nonclassical Mechanisms to Inhibit β-Hematin Crystallization Illuminate the Cooperative Action of Antimalarials
… nonclassical responses. In combination, the heme-dihydroartemisinin adduct and lumefantrine produces ratio-dependent cooperative effects that strongly suppress crystal growth through nonclassical surface remodeling. Finally, a descriptor-based predictive approach demonstrates that site-specific …
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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites
… overall in vitro antimalarial synergy with dihydroartemisinin or atovaquone and additivity with methylene blue in CQS and CQR strains of P. falciparum. 43M1 or 47M1 with mefloquine or lumefantrine displayed in vitro antimalarial synergy in a CQS strain of P. falciparum; however, in a CQR …
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Natural product derivative activates autophagy in cancer cells
… pathways that trigger the mode of cell death. Dihydroartemisinin (DHA), EXP57EA and cisplatin were screened on a selected panel of cancer cell lines: 3 esophageal cancer cell lines WHCO1, WHCO5, KYSE150; one breast cancer cell line MDA-MB-231 and one cervical cancer cell line SiHa. The 3-[4, …
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Mechanism of Action Studies of Phenotypic Whole-cell Active Antimalarial Leads Through Target Identification
… in the action of other antimalarials such as dihydroartemisinin. These results suggest that these compounds may impact different parasite pathways and processes. Besides hemozoin formation, KP124 has also been implicated in interfering with the parasite's protein synthesis. Overall, this work …