Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Digestive System Diseases"”.
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Clinical use of probiotics: A survey of physicians’ beliefs and practice patterns
<p><strong>Background</strong>: Probiotics have the potential to be used as a preventive agent or adjuvant therapy for various medical conditions, and recent research is beginning to illuminate some of the associated benefits. Some clinicians currently prescribe probiotics in practice. …
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Enhancing Microbiome Host Disease Prediction with Variational Autoencoders
… pathology. This can be particularly important in diseases with unknown etiology, providing potential to develop and offer accurate diagnostic tools to clinicians who currently diagnose based on the limited research available or as a diagnosis of exclusion. Human microbiome studies like the Human …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
<p><strong>Introduction:</strong> BRAF V600E mutations are associated with poor clinical outcomes for patients with metastatic colorectal cancer (mCRC). Unlike other tumors with the same mutation, BRAF inhibitors are ineffective as monotherapy. CRC tumors with BRAF V600E mutations are associated …
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
<p>Colorectal cancer is the second leading cause of cancer-related deaths and the third most common cancer in the United States. Although KRAS is mutated in 50% of patients with metastatic CRC (mCRC), it has historically been a challenging therapeutic target. The recent approval of novel covalent …
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Arachidin 3 Modulation of Lipid Metabolism in Rotavirus Infections
<p>Rotavirus (RV) can cause severe and deadly gastroenteritis in young children, infants, and immunocompromised individuals. Previous studies have shown that arachidin 3 (A3) inhibits RV replication, and that RV replication is dependent on the presence of lipids. This study investigated the …
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THE COMPARISON OF EFFECTS OF SYNTHETIC AND NATURAL ARACHIDIN-3 ON ROTAVIRUS INFECTED CELLS
<p>Rotavirus (RV) causes severe, life-threatening diarrhea, in infants, young children and immunocompromised adults. There are several effective vaccines for young children, however they are strain specific and are not protective against many RV strains in developing countries. Therefore, it is …
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In Vitro Analysis of Short Chain Fatty Acids and Human Fecal Microbiota Stimulated by Pectin Sources
… conducted to determine correlations with chronic diseases. Pectin is a naturally occurring biopolymer that has been used in various applications for purposes of pharmaceutical and biotechnology. Pectin is a soluble dietary fiber and can be entirely fermented by gut microbiota. There has been a …
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Lgr5 Regulation of Stat3 Signaling and Drug Resistance In Colorectal Cancer
<p>LGR5 Regulation of STAT3 Signaling and Drug Resistance in Colorectal Cancer</p> <p><em>Tressie Alexandra Capri Posey </em>B.S.</p> <p>Advisory Professor: Kendra Carmon, Ph.D.</p> <p>The greatest difficulty in treating colorectal cancer (CRC) is the development of drug resistance which leads to …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
<p>Macromolecular complexes of cystic fibrosis transmembrane conductance regulator (CFTR) comprise of network of proteins that can regulate cAMP-/cGMP-activated CFTR chloride channel function. We report the physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible …
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Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice
<p>Inflammatory Bowel Diseases (IBD) cause chronic inflammation of the gastrointestinal tract and debilitating symptoms in those suffering from the diseases. After inducing colitis in a mouse model using Dextran Sulfate Sodium (DSS), prebiotics inulin and oligofructose enriched inulin (OEI) were …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
<p>Uncoupling protein 2 (UCP2) is a mitochondrial protein that regulates the flow of protons down the gradient established by the electron transport chain (ETC) without generating ATP, thus uncoupling the proton gradient from ATP generation. In tumors, specifically pancreatic cancer (PDAC), the ETC …
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Identifying Protein Kinase Tbk1 As A Novel Inhibitor of Intestinal Tumorigenesis
<p>Colorectal cancer (CRC) is the third most common cancer diagnosed in women and men， causing almost 600,000 annual deaths worldwide. There is a clear need to understand how CRC forms and progresses in order to improve the strategies of CRC prevention and therapy. A major factor that drives the …
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Methods Development in Inflammatory Bowel Disease
… the known genetic causes for IBD and other diseases by expanding the classifications of disease and utilizing these distinctions. An increased number of genetic loci with known, specific disease progressions will enable physicians with enhanced targeted screening capabilities, leading to an …
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Examining the Relationships and Patterns of Adult Patient Deviation in Populations of Disparity for Colorectal Cancer Screening In Southeast Georgia
<h4><strong><em>Background:</em></strong> The findings from previous studies on the socio-demographic and socio-economic factors associated with non-adherence to Colorectal Cancer Screening (CRCS) in populations of health disparities are inconsistent, and few studies have utilized an integrative …
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Examining the Relationships and Patterns of Adult Patient Deviation in Populations of Disparity for Colorectal Cancer Screening In Southeast Georgia
<h4> </h4> <p><strong><em>Background:</em></strong> The findings from previous studies on the socio-demographic and socio-economic factors associated with non-adherence to Colorectal Cancer Screening (CRCS) in populations of health disparities are inconsistent, and few studies have utilized an …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
<p>Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with dismal prognosis. The only curative option for patients is surgery, but over 80% of patients are not surgical candidates. Unfortunately, PDAC is resistant to the three remaining options. PDAC is characterized by a profoundly …