Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Diffuse Intrinsic Pontine Glioma"”.
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Comprehensive Integrated Genomic and Histopathological Analysis of Paediatric Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is a devastating, inoperable paediatric brain neoplasm with no effective therapy and near 100% fatality. Diagnosis is based mainly on radiological findings and numerous clinical trials using adjuvant chemotherapy over the last four decades have not shown a …
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Elucidating intratumour heterogeneity through investigation of clonal, transcriptomic, and proteomic features across models of triple negative breast cancer and diffuse intrinsic pontine glioma
… disease progression has been well described; and diffuse intrinsic pontine glioma, a paediatric high-grade glioma where nascent insights have revealed a compelling link between heterogeneity and disease severity. To explore these challenges, this work utilises a combination of RNA sequencing based …
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
Paediatric high grade glioma (HGG), including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumours with no effective cures. Lack of understanding of the molecular biology of these tumours, in part due to lack of well-characterised pre-clinical models, is a great challenge in the …
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
… vitro evidence of IMT efficacy against GBM and diffuse intrinsic pontine glioma (DIPG) and has demonstrated potent anti-neoplastic, pro-apoptotic effects of IMT in vitro without significant impact on non-cancerous post-mitotic neurons. The co-application of IMT also potentiates the benefits of …
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Identification and Optimization of Small Molecule Binders for ALK2, USP5, and DCAF1
… ALK2, a kinase involved in the development of diffuse intrinsic pontine glioma, we report the design, synthesis, and evaluation of a first-in-class set of 5- to 7-membered ether-linked and 7-membered amine-linked constrained inhibitors of ALK2. We explored novel scaffold modifications using …
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Comprehensive Analysis of the Molecular Underpinnings of Pediatric Glioma
… tumors affecting children. Of these CNS tumors, gliomas are the most prevalent. Currently gliomas are histologically segregated into two umbrella categories: low-grade glioma (grades 1 and 2, pLGG) and high-grade glioma (grade 3 and 4, pHGG). pLGG are the most frequently diagnosed pediatric …