Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Differentiation factors"”.
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Insights Into the Development of Gastrointestinal Brunner's Glands: Critical Stem Cells and Differentiation Factors
… this is another intestinal marker important for differentiation. Our results showed that Brunner’s Glands do not express Villin. In addition, since Brunner’s Glands are secretory glands, we hypothesized that a transcription factor called SPDEF is critical for proper development as it is an …
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Molecular Consequences of High Taz Expression In Gliomas
… the cell, with consequent silencing of neuronal differentiation factors and an activation of mesenchymal regulators. Directed differentiation of glioma stem cells towards the post-mitotic neuronal state have been shown to be efficient strategies to battle this disease. By establishing the role of …
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The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
… muscle detachment phenotypes, the tendon cell differentiation factors Stripe or activated Mitogen-activated kinase (pMAPK) are missing from the tendon cells. Our data shows that Msk signals from the muscle cell via the secreted Epidermal growth factor receptor (Egfr) ligand Vein to regulate …
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Factors affecting bone cell growth and differentiation under differing culture conditions
Marrow stromal cell (MSC) differentiation into osteoblasts is an important part of the bone growth and remodeling process. This process can be exploited to help solve the problem of bone wound healing. Because of problems with bone grafts, implantation of biodegradable 3D scaffolds seeded with MSCs …
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Control of cell fate decisions of embryonic stem cells by mechanical forces
… to differentiate, in the absence of soluble differentiation factors. Now that we see that mESCs can be directed to differentiation solely by external mechanical forces, we next examined if mESCs can be kept in their pluripotent state by culturing them on soft substrates. We found that soft …
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Differentiation of Normal and Cystic Fibrosis Human Lung Epithelial Cells in a Decellularized and Reconstituted Mouse Lung
… analysis, and immunofluorescence staining of differentiation factors. I also found that this conditional reprogramming method permits cloning of human bronchial epithelial cells, and that these cells can support genetic modification by CRISPR. Next, I developed a method for decellularizing and …
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The Roles of Activin A and B in Liver Inflammation and Fibrosis
… as members of the TGFβ superfamily of growth and differentiation factors. Activin A and B, in particular, have been identified as having roles in the pathophysiology of liver disease, but have not been investigated thoroughly. We treated mice with concanavalin A, a potent T-cell mitogen with liver …
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Growth Differentiation Factor 5 is a Paracrine Regulator of Sarcopenic Obesity
… concurrent muscle mass loss due to aging. Growth differentiation factors (Gdfs) have never been recognized as playing a role in skeletal muscle maintenance in those with SO. Specifically, Gdf5, has been recognized as playing a part in Bone Morphogenic Protein signaling to activate protein …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
… repair, and it is clear that, along with soluble factors, physiological forces play an important role in determining their lineage specification. However, the molecular mechanisms by which external mechanical stimuli are converted to a biological response remain unclear, and few studies have been …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
… on hydrogel substrate with osteogenic differentiation factors of marrow stromal cells. In this thesis, the main result of my research work has been the development of injectable macromer star-poly(lactide-co-glycolide-co-acrylate) (PLGAA). Thus, the goals of work are synthesis design, …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve development. While membrane-bound NRG1 forms (type III) has been strongly implicated in the regulation of myelination process at late stage of Schwann cell …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… The rate-limiting stage in this process is differentiation of oligodendrocyte progenitor cells (OPCs) into mature, myelinating, oligodendrocytes. In animals, agonism of the retinoid X receptor (RXR)-γ enhances remyelination in this way. Metformin also promotes remyelination, this time by …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
… a family of predominantly neuronal growth and differentiation factors that are important for many aspects of nervous system development. In this thesis, both the effects of NRG1 on NMJ development and reciprocal effects of neurotrophic factors on NRG1 expression were studied as a means to …
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FGF signaling in specification of hESC-derived definitive endoderm
… by the expression of multiple transcription factors. Governed by the developmental biological principles that normally control foregut endoderm and pancreas specification, numerous multifactor protocols for directing mature foregut-derived cells from hESCs have been reported. However, to …
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NETWORK META-ANALYSIS OF ORAL AND MAXILLOFACIAL REGENERATION PROCEDURES
… of recombinant human-derived growth and differentiation factors with/without scaffold biomaterial in the treatment of periodontal intrabony defects, through network meta-analysis of pre-clinical studies; 7. to determine the best rank recombinant growth factor formulations agents through …