Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Differential alternative splicing"”.
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PRMT5 Inhibitors in Merkel Cell Carcinoma
… growth in vitro and results in large changes in alternative splicing and more subtle changes in oxidative metabolism. Furthermore, we observe differential alternative splicing of the p53-regulator MDM4, suggesting a possible mechanism for the drug’s greater efficacy in p53-wildtype cell lines.
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Oncogene-driven post-transcriptional regulation in lung cancer
… I found that KRAS variant cells differentially phosphorylated SR protein phosphosites. To determine how KRAS may regulate alternative splicing, I analyzed unique RNA sequencing profiles of lung adenocarcinoma cells ectopically expressing 75 different wild-type or variant alleles …
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Computational analysis and method development for high throughput transcriptomics and transcriptional regulatory inference in plants
… the effects from the transcription and alternative splicing. </p><p class="MsoNormal">We performed a high resolution ultra-deep RNA-seq time-course experiment to study Arabidopsis in response to cold treatment where plants were grown at 20<sup>o</sup>C and then the temperature was …
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An investigation of gene expression, alternative splicing and nonsense-mediated decay in potato in response to Phytophthora infestans infection
… genes in potato.<br/><br/>Dynamic changes in alternative splicing (AS) of NB-LRR genes have been shown in tobacco and Arabidopsis to be essential for the plant response to infection by, for example Pseudomonas. AS occurs in at least 60% of plant genes and is enriched in stress related genes, …