Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Differential Expression Analysis"”.
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Quantitative Approaches for Protein Differential Expression Analysis
… protocols were developed to facilitate differential protein expression analysis and biomarker discovery via a two-step sample interrogation strategy: (a) global protein profiling and differential expression analysis by spectral counting; and, (b) biomarker candidate validation by …
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Comparison of different differential expression analysis tools for rna-seq data
… time. One of the most important tasks of RNA-seq analysis is finding genes that are expressed differently in different subject groups. A lot of differential expression analysis tools for RNA-seq have been developed, but there is no golden standard in this field. In this research, four commonly …
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A Tail-Based Test For Differential Expression Analysis and Pathway Analysis In Rna-Sequencing Data
… research for biomarker discovery and pathway analysis. Such data at the exon-level are usually heavily tailed and correlated. Conventional statistical tests based on the mean or median difference for differential expression likely suffer from low power when the between-group difference occurs …
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Differential Expression Analysis of Type II Toxin-Antitoxin Genes of Pseudomonas aeruginosa PAO1 under Different Environmental Conditions
… ubiquitous presence, no studies have shown the differential expression pattern of its toxin-antitoxins, and persistence related genes. The purpose of the following study is to analyze differential expression of P. aeruginosa PAO1 type II toxin-antitoxins and persistence related genes under …
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Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery
… metabolomics, glycomics etc. Typically, differential expression analysis (e.g., student's t-test, ANOVA) is performed to identify biomolecules (e.g., genes, proteins, metabolites, glycans) with significant changes on individual level between biologically disparate groups (disease cases …
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Comparative analysis of parametric, nonparametric and permutation methods for differential expression
DNA microarrays permit us to study the expression of thousands of genes simultaneously. They are now used in many different contexts to compare mRNA levels between two or more samples of cells. Microarray experiments typically give us expression measurements on a large number of genes. Increasing …
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SEA: a novel computational and GUI software pipeline for detecting activated biological sub-pathways
… the genes on different pathways using differential expression analysis. Unfortunately, they do not adequately capture the relationships of the genes amongst one another. Structure Enrichment Analysis (SEA) thus seeks to take biological analysis to the next level. SEA accomplishes this …
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Strain-resolved transcriptomics: exploring functional heterogeneity of the gut microbiota in health and disease
… variation that is present across them. My analysis revealed that closely related bacterial strains exhibit dramatically different transcriptional programs, with some strains enriched in IBD patients showing upregulation of genes involved in stress response, sugar metabolism pathways, and …
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Implementation, adaptation and evaluation of statistical analysis techniques for next generation sequencing data
… thought possible using standard methods. Analysis of sequencing data such as SAGE (serial analysis of gene expression) and microarray data has been a popular area of research in recent years. The increasing development of these different technologies and the variety of the data produced …
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The effect of age on human monocyte epigenetics and function
… it is extracted in vivo. Spearman correlation analysis, differential expression analysis and functional enrichment analysis were used to identify which genes and pathways exhibit changes with age, be it in their methylation level or their transcription. It was determined that differentially …
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The Effect of Diet on Venom Gene Expression in Tetragnatha versicolor
… that feed on different insect species also differentially express venom genes. First, I determined whether two populations of T. versicolor were eating different prey species by measuring the [delta]15N values of T. versicolor from each site. The results of this analysis were that the …
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Genetic and molecular factors regulating growth and morphology in Senegalese sole (Solea senegalensis)
… its genetic estimates. Principal component analysis identified four symmetric and four asymmetric components that affected main body regions (head, body, and caudal fin) and were modulated by sex, the evaluation batch, and amoeba lesions. Symmetric components, that explained 68.8% of total …
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Exploring the gene regulatory dynamics of the maturing human brain
… factors. The complexity and dynamics of gene expression and regulation at the cell type-specific level are still poorly understood, especially during the process of brain maturation. The overall aim of this project was to obtain a better understanding of how the brain cell atlas changes over …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
… for HCC are extremely limited. Here, RNA-Seq expression data originally from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) project were used to compare truly healthy liver tissues, a base-line level often excluded from cancer studies, to both non-tumor and tumor …
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Direct selection on lifespan in Drosophila Melanogaster to elucidate the mechanisms of longevity
… damage is not an indicator of lifespan. Differential expression analysis of the long-lived flies revealed enrichment of developmental and metabolic biological processes amongst the genes with the highest fold-change. These categories are commonly altered in long-lived expression profiles …
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Desiccation-driven senescence in the resurrection plant Xerophyta schlechteri (Baker) N.L. Menezes
… tissues continue this process after rehydration. Analysis of the transcriptome was done using RNA-Seq, which was subject to differential expression analysis and network analysis to elucidate the potential mechanisms for senescence regulation in this species. Significantly increased transcription …
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The elucidation of immunological and oncological transcriptomic signatures using translational ontologies and next-generation sequencing
… “An Ontology-based Pipeline for Transcriptomic Analysis,” the computational approaches to next-generation sequencing will be integrated with the ontologies created in chapter 2. Here, a novel pipeline will be presented which encapsulates quality control, normalization, quantification, …
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Comparison of dispersion metrics for estimating transcriptional noise in single-cell RNA-seq data and applications to cardiomyocyte biology
… and variability. Single-cell RNA sequencing data analysis often focuses on comparing transcription levels. However, these analyses capture only a portion of the wealth of information conveyed by transcription. The quantification and analysis of transcriptional variability poses an opportunity to …
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Systematic analysis of the role of differential expression of microRNAs associated with cell death decisions
The link between abnormal microRNA expression and cancer has been widely reported. However, little is known about the relationships between temporal microRNA expression and changes in cell behavior. To better understand how microRNA expression is involved in cell responses it is necessary to know …
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Comparing Differentiated Rod And Cone Transcriptomes Reveals Rax As A Controller Of A Defined Cone Gene Regulatory Program
… the same retinal samples we designed a double expression cassette (“double fluo”) encoding mCherry under the transcriptional control of the human G-protein coupled receptor Kinase 1 (GRK1) gene rods and cones-specific promoter elements of, and eGFP under the transcriptional control of …
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