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Showing 1 to 16 of 16 for “"Diethyldithiocarbamate"”.
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Colorimetric determination and speciation of arsenic with silver diethyldithiocarbamate
The Silver Diethyldithiocarbamate (SDDC) Method is a widely used colorimetric technique for the determination of aqueous arsenic. The chemistry of the process is discussed in detail, and the method is compared to the other Environmental Protection Agency approved arsenic methods. Original …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… to form metal-metabolite complexes (zinc/copper diethyldithiocarbamate), which are the active anticancer compounds. Diethyldithiocarbamate (DDC), a metabolite of DS, has previously been trialled in clinics to treat HIV patients due to its immunomodulatory properties. Zinc diethyldithiocarbamate …
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The potential of the superoxide dismutase inhibitor, diethyldithiocarbamate as an adjuvant to radiotherapy
… toxicity. SOD activity can be inhibited by diethyldithiocarbamate (DOC), a powerful copper chelator. If inhibition of SOD by DOC increases the lifetime and effectiveness of radiation induced O₂⁻, it follows that the potential exists for DOC to enhance the effect of radiation. DOC is however …
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The Determination of Lead and Cadmium in Tobacco Using High Performance Liquid Chromatography and Dithiocarbamate Derivitization.
… that is capable of resolving lead and cadmium diethyldithiocarbamate complexes. The method does not require the presence of hazardous solvents to optimize peak shape and resolution; the mobile phase consists of methanol, water, and a surfactant. Tobacco samples were chemically oxidized and …
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In vitro investigation of the anticancer activity and molecular mechanisms of action of albumin nano-encapsulated copper/zinc diethyldithiocarbamate in human pancreatic cancer cells
… chelated with Cu²⁺ or Zn²⁺ ions to form copper diethyldithiocarbamate (Cu(DDC)₂) or zinc diethyldithiocarbamate (Zn(DDC)₂). However, the clinical anticancer application of DSF is hindered by a short plasma half-life (<4 minutes) and bioavailability challenges from separate Cu/Zn supplementation. …
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Total synthesis of ferrugine and synthetic studies towards ferrugine and stemofoline
… a carbamoyl radical, generated from a carbamoyl diethyldithiocarbamate, onto an unactivated pendant alkene, followed by group transfer of the dithiocarbamate moiety. The carbamoyl radical cyclisation precursor was synthesised from a known seven-membered ring carboxylic acid. The diastereomeric …
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Cholesterol metabolism in the endoplasmic reticulum of rat liver
… was low. Dithiothreitol, 4-phenyl-imidazole, diethyldithiocarbamate and glycerol, by themselves or in combination with each other, were shown to be useful agents in liver microsomal cytochrome P-450 purification. It was further demonstrated that increasing the recovery of cytochrome P-450 gave …
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The synthesis and fungicidal activity of some novel phosphoramidates
… morpholine, piperazine, dimethyldithiocarbamate, diethyldithiocarbamate, xanthate and 5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxylate. Preliminary investigations were carried out into the synthesis of compounds containing the 1,1,1-trichloro-2-(bisdimethylaminophosphinyl- amino)ethyl group via the …
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The Electrochemical Characterisation of Carbon-based Nanomaterials and their Application in the Detection of Heavy Metal Ions
… the modification of an electrode with a ligand, diethyldithiocarbamate (DDC) via its incorporation into a Nafion film. The electrochemical detection of Cu(II) at this sensor was based on its complexation to DDC and the cycling of Cu(II) to Cu(I). The detection mechanism was investigated using …
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Studies in organobismuth chemistry
… drying times with the addition of bismuth tris-diethyldithiocarbamate, which may promote the cross-linking reaction that occur in paint films during the drying process. Examples are reported to illustrate the great reductions in reaction times possible when using microwave energy. Reactions such …
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Ultrafast extreme ultraviolet spectroscopy of transition metal dithiolate coordination complexes
… dithiocarbamate complex, Ni(dedtc)2 (dedtc = diethyldithiocarbamate, S2CNEt2) was studied as a simple analogue of a square planar nickel-centered hydrogen catalyst. Examination of this complex and the equivalent copper and zinc complexes reveal new phenomena in XUV spectroscopy, including …
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The protective role of tumour necrosis factor alpha in the heart
… this myocyte protection, the NFₖ B antagonists diethyldithiocarbamate (DDTC 10mM) or sodium salicylate (SA 100μM) were co-administered with TNFα. The myocyte protective effect of TNF a was significantly decrease with both antagonists, although not completely inhibited/blocked (DDTC - attenuated …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… Cu. The delayed killing is caused by the complex diethyldithiocarbamate (DDC) and Cu (DDC-Cu), the final product of the reaction. The cytotoxicity of both phases needs the intact DS. However, due to the extremely short half-life of DS in the bloodstream, the anticancer efficacy of DS has been …
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A Novel Antibiofilm Treatment for Surgical Site Infections
… can be administered locally on SSIs. Repurposed diethyldithiocarbamate (DDC-), a metabolite of the old anti-alcoholic drug Disulfiram, previously showed antibacterial activity against mycobacteria and streptococci in combination with copper ions (Cu2+) but had not been investigated against S. …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… were also treated with the liver injury agent Diethyldithiocarbamate (DDC) for 4 weeks to expedite the development of CCA. To identify the pathological characteristics of mice tumor, H&E staining, and Immunohistochemistry (IHC) targeting oncogenes and HCC/CCA markers were applied. We …
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Interactions of paraquat and nitrodiphenylether herbicides with the chloroplast photosynthetic electron transport in the activation of toxic oxygen species
… acifluorfen-methyl, nitrofen, and nitrofluorfen. Diethyldithiocarbamate (DEDTC) does not accept electrons from the photosynthetic electron transport (PET), but can donate electrons to a photosystem I (PSI) Mehler reaction in the presence of the following PET inhibitors: diuron, …