Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 183 for “"Diet-induced"”.
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Diet-induced thermogenesis in the domestic chicken
… or calorie-protein imbalances were induced by providing glucose solutions (16% w/v) in lieu of water in the first experiment, and by force-feeding the diet to crop capacity in the subsequent trials. Feed restriction was accomplished by providing 75% of ad libitum intake each day. …
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Systems biology of diet-induced hepatic insulin resistance
… resistance. We fed male C57BL/6J mice high-fat diets (HFD) to induce obesity and insulin resistance. In the first presented study, our group collected datasets to profile the hepatic epigenomes, transcriptomes, proteomes, and metabolomes of chow diet (CD) control and HFD-fed mice. I extended and …
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Orexin Signaling and the Prevention of Diet-Induced Obesity
… transgenic mice confer resistance to high-fat diet-induced obesity and insulin insensitivity by promoting energy expenditure and reducing food consumption. Genetic studies indicated that orexin receptor-2 (OX2R), rather than orexin receptor-1 (OX1R) signaling, predominantly mediates this …
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SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice
… Conversely, chronic feeding on high caloric diets brings about opposite outcomes and can progress to type-II-diabetes and obesity. An intense effort by many researchers has begun to elucidate the homeostatic mechanisms accounting for these beneficial metabolic effects of CR in order to …
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Low-grade aldehyde stress protects mice from diet-induced obesity
… are resistant to obesity and onset diabetes induced by high glucose and fat dietary challenges. This protection is mediated by GDF15, a hormone that is elevated in response to endogenous formaldehyde stress when DNA repair is intact and causes a decrease in food consumption during the dietary …
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Diet Induced Alteration of the Murine Intestinal Microbiome After Antibiotic Ablation
Background and Objective: We detected a dominant non-cultivatable gram-positive coccobacillus associated with cultivatable yeast in feces of mice treated with a cocktail of broad-spectrum antibiotics while being fed a partially defined mouse chow that is commonly used for nutritional studies. The …
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Role of Lipolysis and Lipogenesis in the Development of Diet-Induced Obesity
… cause or simply the result of the obese state. Diet-induced obesity is one of the animal models that allow researchers to address temporal issues. Our laboratory utilizes a diet-induced obesity model in which Sprague-Dawley rats are placed on a purified moderately high fat diet and ultimately …
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The impact of diet-induced obesity and exercise on adipose-resident stem cells
… C57BL/6J mice were placed on control or high fat diet (HFD) for 8 wk prior to and following initiation of a 16 wk treadmill exercise program. ADSCs (Sca-1+CD45-) were isolated from epididymal adipose tissue and mRNA was evaluated using high throughput qPCR. While resulting in a total increase in …
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SEC16B modulates high fat diet induced obesity in female but not male mice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Diet-induced-obesity suppresses beta-catenin and promotes cell proliferation during colon development
The student, Guanying Xu, submitted this Thesis for approval on 2018-07-17 at 11:44.
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Mechanisms of Western-Diet Induced Endothelial Stiffening: Endothelial CD36 and Long-Chain Fatty Acids
Western diet (WD) refers to a diet high in saturated fat and refined carbohydrates. WD is known to be detrimental to cardiovascular health. These studies present novel insights into the mechanism undergirding WD-associated cardiovascular dysfunction: stiffening (an increase in the elastic modulus) …
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The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity
… and myelin accumulate in the ME during diet-induced obesity (DIO). The work presented in this thesis further characterises ME oligodendrocyte lineage cell physiology in DIO mice and demonstrates that changes in oligodendrocyte lineage cell plasticity occur in response to subacute …
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FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance
… that abundant LA found in the modern western diet will be converted to AA promoting an inflammatory phenotype. The present study is to determine the interaction of heterozygous knockout (HET) or transgenic overexpression (TG) of FADS2 in mice fed high fat diets (HFD), as well as the …
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Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice
… manner. Most intriguingly, upon chronic high-fat diet (HFD) consumption by the host, B1 cell phagocytosis starts to lose antigen-specificity for PtC. Morphologically, some of these B1 B cells in DIO mice show enlarged cytosol and engulfed more beads, indicating a transition to macrophage-like …
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Near-Infrared Light Reduces Glia Activation and Modulates Neuroinflammation in Brain of Diet-Induced Obese Mice
… was tested whether NIR light may prevent obesity-induced neuroinflammation, in a diet-induced obese mouse model of obesity. After 13 weeks of high-fat diet (HFD), the mice received the NIR light treatments for 4 weeks in single daily sessions of 90 seconds each. The immunostaining investigations …
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Impact of saskatoon berry powder on metabolism and gut microbiota in diet-induced insulin resistant mice
… markers caused by high fat-high sucrose (HFHS) diet. Certain bacteria in the mouse gut, such as Muribaculaceae, was significantly increased by 5% SBp (w/w) or equivalent amount of C3G in 5% SBp. Correlation results revealed that some bacterial families, such as Muribaculaceae and …
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Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated H[subscript]2O[subscript]2 emission from muscle mitochondria, and that …
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Viral Delivery of the Fat-1 Gene to Treat Post-Traumatic Arthritis with Diet-Induced Obesity
… Due to the difficulty in switching patients’ diets, an alternative solution to increasing omega-3 levels needs to be developed. The Fat-1 enzyme, an omega-3 desaturase that has the ability to convert omega-6 to omega-3 fatty acids, may be a good target for increasing the omega-3 levels in the …
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Sex differences in diet-induced regulation of non-exercise activity thermogenesis in overweight and obese adults
… have been proposed as factors that may hinder diet-induced body mass loss. Although diet-mediated changes in PAEE and BMR are subject to large inter-individual variability, research investigating the impact of sex on diet-induced modulation of PAEE and BMR is lacking. Therefore, this study …
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