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Showing 1 to 20 of 64 for “"Diclofenac"”.
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Formulation and evaluation of diclofenac sodium dispersible tablets
Diclofenac sodium is a non-steroidal, anti-inflammatory drug used for the relief of pain and inflammation. Many patients have difficulty swallowing tablets and consequently do not take medication as prescribed. To achieve optimum benefit of a drug, it is desirable to present it in a formulation …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
Mini-matrix multiple unit dosage forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and …
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The use of ion pairs to increase the percutaneous delivery of diclofenac
Like many topically applied formulations, diclofenac (DF) preparations face delivery challenges due to the highly effective skin barrier. This research explored a novel amino acid-based ion pairing strategy to enhance percutaneous DF delivery through rational counterion selection and solvent …
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Potentiometric and spectrophotometric investigation of copper diclofenac as an anti inflammatory drug for the treatment of Rheumatoid Arthritis
Copper and Diclofenac (DCL) separately, are used to alleviate inflammation associated with RA. It has been postulated that their combination would have a synergistic effect i.e., their combination would be more effective than when administered independently. Cu(II)-DCL system is studied …
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The relative effectiveness of spinal manipulative therapy compared to Diclofenac sodium, in the management of mechanical low back pain
A dissertation presented in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Durban, South Africa, 2001.
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Aqueous humor concentration and prostaglandin E2 suppression efficacy of topically applied ophthalmic ketorolac 0.5% and diclofenac 0.1% solutions in dogs with cataract
… utilized topical ophthalmic NSAIDs in dogs, diclofenac 0.1% and ketorolac 0.5%. Animals: Twenty-two client owned dogs (22 operated eyes) presenting to the VTH ophthalmology service for routine cataract surgery for mature or hypermature cataract. Methods: Subjects were randomized to be treated …
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A comparative study of the effects of meclofenamate, diclofenac and placebo, in combination with physiotherapy, on the healing of acute quadriceps and hamstring muscle tears
… anti-inflammatory drugs, meclofenamate and diclofenac, in combination with physiotherapy treatment, on the rate and extent of healing of acute hamstring muscle tears. Sixty patients were recruited and treated at No's 1 and 2 Military Hospitals in Voortrekkerhoogte and Wynberg, Cape Town, …
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Drug release from pellets and matrices based on cellulose ethers.
… the release of metoclopramide hydrochloride or diclofenac sodium from coated pellets or matrices. The glass transitions of the polymeric films were determined by thermomechanical analysis and used as a guideline to select the inlet air temperature m coating operation. The coating procedure was …
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The effects of select non-steroidal anti-inflammatory drugs on green and brown hydra
… were observed between ibuprofen, naproxen, diclofenac toxicity and select endpoints in Hydra. However, these correlations generally occurred in only 25% of the 7 day exposure toxicity tests performed. Thus, environmentally relevant concentrations of ibuprofen, naproxen, and diclofenac did …
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Comparison of Two Advanced Oxidation Processes for Their Production of Hydroxyl Radicals and Evaluation of a UV/Ozone AOP at Varying UV Fluence for Treating Diclofenac
… of a representative emerging contaminant, diclofenac (DCF). The sleeves made to alter the UV dose were not found to change the UV dose enough to show a consequential difference in degradation for the fluence indicator atrazine (ATZ) or the emerging contaminant DCF. Further testing with …
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Effectiveness of proprioceptive neuromuscular facilitative stretching combined with administration of Diclofenac compared to proprioceptive neuromuscular facilitative stretching and placebo medication for the treatment of cervical facet syndrome
Dissertation submitted to the Faculty of Health in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Technikon Natal, Durban, South Africa, 2001.
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Pharmacokinetic and Pharmacodynamic Modelling to Advance Perioperative Anaesthesia and Analgesia
… with two non-steroidal anti-inflammatory drugs. Diclofenac dosing in children is currently extrapolated from adult data. I modelled paracetamol and diclofenac analgesia using a modified EMAX model with placebo effects and interval censored dropout. Diclofenac and paracetamol effects were …
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NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein
… These studies also determined if the drug diclofenac, a non-steroidal antiinflammatory (NSAID) that is commonly administered in conjunction with opioids during peripheral inflammatory pain (PIP), altered or modulated P-gp functional expression providing evidence of a drug-drug interaction. …
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Stimuli-responsive self-assembling materials comprising amphiphilic copolymers for localized remotely triggered therapeutic delivery
… poly(L-glutamic acidtriethylene glycol-diclofenac) copolymer micellar aggregates for near-infrared responsive enhanced therapeutic delivery. It was discovered that the films released small-molecule non-steroidal anti-inflammatory drug diclofenac up to five-fold faster during remote …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… proposed to enhance dermal bioavailability of Diclofenac acid, a potent nonsteroidal anti-inflammatory drug (NSAID) with a very low aqueous solubility. T3, is a thyroid hormone normally synthesized and secreted by the thyroid gland and through interaction with its nuclear receptors (TRs) plays …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
… preventative effects of anti-inflammatory (diclofenac) and antioxidant (C E Ferulic and vitamin E) agents on UVB-induced carcinogenesis in male and female mice. Our results demonstrated that despite observed sex differences in the inflammatory response, prolonged topical diclofenac treatment …
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New lipid nanovesicles as topical delivery sistems for ant-inflammatory drugs
… the topical delivery of anti-inflammatory drugs: diclofenac, quercetin and curcumin. In the first work concentrated and interconnected penetration enhancer containing vesicles (PEVs) are proposed as carriers for dermal delivery of diclofenac. PEVs were prepared by using a commercial …
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Proteomic approaches to environmental stress in mussel Mytilus edulis due to emerging classes of anthropogenic pollutants
… anthropogenic pollution on selected chemicals. Diclofenac is an example of veterinary and human pharmaceuticals, an emerging category of chemical pollutants, with potential to cause serious toxicity to non-target organisms. A second chemical used for this study was copper which is a key source …
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Development and Validation of a Novel Diffusion Chamber for In Vitro Permeability Testing of Topically Delivered Spray Formulations
… chamber, was validated using two model drugs, diclofenac sodium and lidocaine hydrochloride. Shed snake skin was used as a model for human stratum corneum in these studies. Paired in vitro diffusion studies were performed using commercial and lab generated formulas for each drug in both …
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Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
… mg/kg, i.p.) or the nonselective COX inhibitor diclofenac sodium (1-100 mg/kg, i.p.) and tested for mechanical and cold allodynia. Then, both drugs were coadministered at various doses in ratios of 1:3, 1:1, and 3:1 parts of either compound. Isobolographic analyses revealed that combining low …
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