Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Dicer-2"”.
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Regulatory Mechanism of the RNAi Pathway
… post-transcriptional gene silencing initiated by Dicer, a RNase III that processes double-stranded RNA (dsRNA) precursors into small interfering RNA (siRNA). In Drosophila, Dicer2 and R2D2 coordinately recruit duplex siRNA to the effector RNA-induced silencing complex (RISC), wherein …
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Reading Between the Strands: Deciphering Double Stranded RNA-Based Immune Responses in Mosquito-Virus Interactions
… further characterized non-canonical functions of Dicer-2 (Dcr-2), a key RNAi component known to bind viral dsRNA. Using a CRISPR-generated Dcr-2 knockout cell line, coupled with poly(I:C)-based proteomics and transcriptomic profiling, we demonstrate that Dcr-2 regulates immune gene expression and …