Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Dicer KO"”.
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… the development of T1D development by deleting Dicer1 (an enzyme needed for miRNA maturation) early in thymocyte development. We showed that these NOD.Lck-Cre Dicer KO mice had phenotype alterations including markedly decreased amount of αβ CD4+ and CD8+ T cells in the secondary lymph nodes but …
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Modulation of Ago-miRNA regulatory networks by cis-sequence elements and target competition
… of Ago by performing CLIP in cells that lack Dicer, an enzyme required for mature miRNA biogenesis. We surprisingly found that Ago bound a similar set of genes in the absence of Dicer, and this overlap in target genes was due partially to residual, unprocessed miRNAs in the Dicer KO cells. …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… tissues from wild-type versus miR-183 family knockout (KO) mice. Bulk RNA sequencing revealed numerous gene expression changes in the cochlear sensory epithelium and spiral ganglion due to miR-183 family loss-of-function. However, these changes in gene expression represent an average across the …