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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Dicarbonyl"”.
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Combinational Therapy to Mitigate α-Dicarbonyl Toxicity
… diabetes have high concentrations of reactive α-dicarbonyls (α-DCs) like, methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, …
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Synthese und kolloidale Eigenschaften neuartiger Blockcopolymere mit beta-Dicarbonyl Einheiten = Synthesis and colloidal properties of a novel type of block copolymers bearing beta-dicarbonyl residues
… of amphiphilic diblock copolymers bearing b-dicarbonyl (acetoacetoxy) chelating residues. Polymers were obtained by Group Transfer Polymerisation (GTP)/acetoacetylation and controlled radical polymerisation techniques (RAFT).Different micellar morphologies of poly(n-butyl …
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Preparation And Characterization Of Meridionally Trischelated Rhenium(i) Terpyridine Dicarbonyl Complexes
… coordinated tridentate terpyridine rhenium dicarbonyl complexes. The complex mer,cis-Re(tpy-κ<super>3</super>N)(CO)<sub>2</sub>Cl (1) undergoes facile chloride substitution to produce a variety of complexes of the type mer,cis-[Re(tpy-κ<super>3</super>N)(CO)<sub>2</sub>(L)]n, …
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An exploration of the solid-state architectures formed by 1,8-naphthyridine-2,7-dicarbonyl derivatives
Building on previous studies of tape formation by dicarbonyl substituted pyridine derivatives in the solid state, it was proposed that expansion of the hydrogen bonding array from three donor-acceptor pairs to four should increase the strength of the hydrogen-bonded array. Accordingly an …
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Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans
… of highly oxidative byproducts produced from α-dicarbonyl compounds (α-dcs), which are highly reactive molecules that bind indiscriminately to protein and DNA and, are regulated by a conserved glyoxalase system (<em>GLO1</em> and <em>DJ-1</em>) in humans. Utilizing the conserved glyoxalase …
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Synthesis, structures and studies of organoiron compounds
… for the (η⁵-cyclopentadienyl) iron (II) dicarbonyl group by variable temperature ¹H NMR spectroscopic studies on cis-4-phenyl-1-(η⁵-cyclopentadienyl) iron (II) dicarbonyl cyclohexane. This is the first determination of the A value of a group with a transition metal directly attached to a …
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The selective palladium-catalysed decarboxylative coupling of nucleophiles in the presence of propargylic electrophiles
… regioselective decarboxylative coupling of 1,3-dicarbonyl compounds and nitrogen nucleophiles in the presence of propargylic electrophiles. The first part of this thesis focuses on the palladium-catalysed cross-coupling reaction involving two 1,3-dicarbonyl compounds in a regio- and …
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A polarographic study of the reduction of unsymmetrical benzils.
… was the preferred reaction site. However, the dicarbonyl system was nevertheless reduced as a unit, and Hammett sigma values of disubstituted symmetrical benzils were approximately additive. This was ascertained by comparing the ease of reduction of eight unsymmetrical benzils to the ease of …
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Pyrrolo [2-3-b] Pyridines of Potential Chemotherapeutic Value
… and their reaction with 1,3-dicarbonyl reagents to give pyrrolo [2. 3- b] pyridines: is discussed. The two-stage synthesis of pyrrolo[ 2, 3- b] pyridin-4 (7H)- ones from 2-amino-4-cyanopyrroles and diethyl ethoxymethylenemalonate is discussed. The preferred orientation of …
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A Quantitative Analysis of Solvent Effects on Keto-Enol Tautomeric Equilibria
… representative of the major classes of (beta)-dicarbonyl and phenolic tautomeric equilibria, are determined in a variety of solvents by high dilution FT NMR and UV studies. O-Methylated enol ethers are used as models for the ultraviolet chromophores of dimedone and …
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Synthetic, structural and molecular modelling studies of organoiron complexes of catalytic importance
… and characterization of a series of new alkyl dicarbonyl pentaznethylcyclopentadienyl iron compounds, [(η⁵-C₅(CH₃)₅)Fe(CO)₂R], is the starting point for an investigation of these compounds and their relevance as models for catalytic reactions. The compounds have been synthesized by the reaction …
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Cobalt stabilized gamma-chloroalkynones and alkynoates as gamma-carbonyl cation synthons.
… enol ethers (102-104) generated 2-alkynyl-1,6-dicarbonyl compounds (134-149) in poor to good yields. Products of 101, with a non hydrogen substituent at the propargyl site, with 102 and 103 generated syn and anti diastereomers. The ratios of syn:anti diastereomers range from 1.3: 1 to 2.1: 1 …
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Chemical Studies on Nucleic Acid Analogues
Dicarbonyl aldehydes are known to react preferentially with guanine residues in both DNA and RNA; however, the exact structure of the modification product has never been assigned unequivocally as either the "linear" or the "bent" isomer. Accordingly, we have synthesized the products of guanine …
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The Syntheses of Bis-Guanidium Salts and Their Applications in Asymmetric Mukaiyama Type SN2 Alkylation Reactions
… these catalysts in asymmetric catalysis of 1,4-dicarbonyl compounds via Mukaiyama type SN2 alkylation reactions. Firstly, a series of bis-guanidium salts were synthesized from commercially available and cheap chiral sources in 4 to 5 steps. For most of the derivatives, the overall yields were …
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Synthesis and stabilities of mononuclear iron (II) dicarbonyls derived from neutral NNS ligands : structural models of the apo-active site of mono-iron (Hmd) hydrogenase
… the syntheses and characterization of iron dicarbonyl complexes derived from tridentate ortho-substituted Schiff base pyridine/thioether ligands ([subscript R]NNS) and (Fe(CO)₄(Br)₂). Two general synthetic routes are reported for the isolation of such iron carbonyls. First, metalation of …
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Palladium(II)-Catalysed sp 3 C–H Functionalisation of Hindered Amines and its Application in Synthesis of Astemizole Analogues
… b-position of terminal ketones, generating 1,4- dicarbonyl moieties which are important synthetic building blocks. The sterically promoted C–H functionalisation strategy has been employed as the key step in the synthesis of a functionalised analogue of astemizole, a pharmaceutical agent which …
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The Effects Of Noncovalent Interactions Studied By Ultrafast Two-Dimensional Infrared Spectroscopy
… spectroscopy. Bis(cyclopentadienyl ruthenium dicarbonyl) dimer and bis(cyclopentadienyl iron dicarbonyl) dimer are two fluxional metal carbonyl complexes that exist as multiple isomers in dynamic equilibrium in solution. However, when encapsulated by self-assembled cages, the dynamic …
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Grundlegende Untersuchungen zum CVD-Wachstum Fe-gefüllter Kohlenstoff-Nanoröhren
… dienten Ferrocen und Cyclopentadienyl-eisen-dicarbonyl-dimer. Für die Darstellung von CNT-Ensembles mit idealerweise paralleler Ausrichtung der Einzelindividuen kamen thermisch oxidierte Si-Substrate (Schichtdicke des Oxid: 1 µm) zum Einsatz. Das Wachstum der CNTs wurde überwiegend als …
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Development of a catalytic enantioselective intramolecular Stetter reaction: catalyst development and synthetic applications
… Synthetically important enantioenriched 1,4-dicarbonyl compounds can be generated in a single operation from achiral materials. The Stetter reaction has been developed to construct challenging quaternary stereocenters with good efficiency and very high selectivity. The scope of this …
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