Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Diastolic dysfunction"”.
-
Novel mechanisms of diastolic dysfunction in diabetes
… cardiomyopathy is primarily characterised by diastolic dysfunction and deranged cardiomyocyte performance. The underlying mechanisms are unknown, and specific treatment targets are lacking. Recent findings (Mellor et al, publication pending) have shown that glycogen accumulation is a …
-
Quantitative Hydrodynamics Analysis of Left Ventricular Diastolic Dysfunction using Color M-Mode Echocardiography
Numerous studies have shown that cardiac diastolic dysfunction and diastolic filling play a critical role in dictating overall cardiac health and demonstrated that the filling wave propagation speed is a significant index of the severity of diastolic dysfunction. However, the governing flow physics …
-
Impact of diastolic dysfunction on physical function and body composition in maintenance hemodialysis patients
… metrics related to left ventricular systolic dysfunction (LVSD) such as ejection fraction (EF) are commonly used to predict adverse CV outcomes, LV diastolic dysfunction (LVDD) measures may provide better prognostic values in MHD patients because they are less sensitive to blood volume …
-
Studies of Stented Arteries and Left Ventricular Diastolic Dysfunction Using Experimental and Clinical Analysis with Data Augmentation
… set of experiments investigated Left Ventricular Diastolic Dysfunction (LVDD) using phase contrast magnetic resonance imaging (pcMRI). Using this technique, ten patients with and without LVDD were scanned and a 2D portrait of blood flow through their heart was obtained. To augment this data, …
-
Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
… is sufficient to detrimentally impact myocardial diastolic function, and to investigate mechanisms by which this might occur. In Chapter 3, the association between NAFLD and HFpEF is established in a murine model, demonstrating that murine models are suitable for use in this research. In Chapter …
-
The effects of aging on cardiac mechanics
… the aging heart exhibits left ventricular (LV) diastolic dysfunction and changes in mechanical properties, which have been attributed to alterations in the extracellular matrix (ECM). The investigators tested the hypothesis that the mechanical properties of cardiac myocytes significantly change …
-
Impact of Glycemic Therapy on Myocardial Sympathetic Neuronal Integrity and Left Ventricular Function in Insulin Resistant Diabetic Rats: Serial Evaluation by 11C-meta-Hydroxyephedrine Positron Emission Tomography
… confer cardiovascular risk, particularly for diastolic dysfunction. Diabetes is associated with elevated myocardial norepinephrine (NE) content, enhanced sympathetic nervous system (SNS) activity, altered resting heart rate, and depressed heart rate variability. Positron emission tomography …
-
Point-of-care ultrasound abnormalities in late onset severe preeclampsia: prevalence and association with serum albumin and brain natriuretic peptide
… interstitial edema, cerebral edema, and cardiac dysfunction. Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. We investigated the prevalence of pulmonary interstitial syndrome …
-
Sex dimorphism in the cardiometabolic effects of the smoothelin-like 1 protein deletion in an ageing mouse model
… (LV) stiffness causally linked to endothelial dysfunction and coronary microvascular inflammation. SMTNL1, also highly expressed in skeletal muscle, can impact the energy metabolism and insulin sensitivity of female mice during pregnancy. Therefore, I investigated the metabolic and cardiac …
-
Hydrodynamics of Cardiac Diastole
… filling and ejection of the left ventricle. Diastolic filling is controlled by the left ventricular recoil, relaxation, and compliance as well as atrial and ventricular pressures making left ventricular diastolic dysfunction very difficult to understand and diagnose. An improved understanding …
-
Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… appear in myocardial tissue, characterized by diastolic and systolic dysfunction, and eventually heart failure. While specific changes associated with DC are well characterized, the mechanism underlying disease development and progression as a whole remain to be elucidated. The ability of …
-
Feasibility of Echocardiographic Particle Image Velocimetry for evaluation of cardiac left ventricular filling function
… ailments eventually precipitate the onset of diastolic dysfunction and heart failure. Diastolic dysfunction is the alteration or impairment of performance in either the left or right ventricle of the heart. Although there has been a marked increase in study of this disease, there is still an …
-
Exploring the role of Wnt signalling in heart failure with preserved ejection fraction.
… hypertension, cardiac hypertrophy and fibrosis, diastolic dysfunction (measured via pressure volume loop analysis), but there was no evidence demonstrating activation of canonical Wnt signalling in the hearts of these animals. Thus, on the basis of this study, a role for canonical Wnt signalling …
-
Studies of vascular function in patients with heart failure and either preserved or reduced left ventricular systolic function
… ventricular (LV) relaxation and filling, or LV diastolic dysfunction. As a result, it has been proposed that LV diastolic dysfunction is the primary pathophysiological process in HF-PSF. However, population-based studies have shown that there is poor correlation between the presence of LV …
-
The role of contemporary echocardiography in the management of heart failure
… techniques for assessment of both diastolic and systolic function to ascertain their effectiveness and optimal utility. Assessment of systolic function in HF patients is optimised by the use of harmonic imaging and not enhanced with the use of transpulmonary contrast agents, whilst …
-
The effect of metformin intervention on the programming of cardiometabolic health in offspring of obese pregnancy
… led to exaggerated adiposity and adipose tissue dysfunction in a sex- and a time-dependent manner. In both sexes, exposure to metformin during obese pregnancy caused adipocyte hypertrophy at 8 weeks of age prior to development of obesity. In males this was associated with adipocyte hyperplasia, …
-
Predictors of diffuse myocardial fibrosis in HIV infected persons: A multiparametric cardiovascular magnetic resonance study
… that is now largely characterised by diastolic dysfunction. Our hypothesis was that ART would be associated with regression of myocardial fibrosis in HIV. Myocardial fibrosis is associated with an unfavourable outcome in many different clinical settings. In this study, we used …
-
Development of an experimental system to determine the contribution of titin and collagen to passive stiffness of myocardium
Diastolic dysfunction is known to be a major factor for congestive heart failure in aged humans and other mammals. The main contributors to increase in the myocardial stiffness, hindering the cardiac mechanics, are alterations in intracellular titin and extracellular collagen matrix. Titin is a …
-
Heart in Polycystic Kidney Disease is Characterized by Cardiac Dysfunction and Structural Deformation
… hypertrophy and fibrosis, causing cardiac dysfunctions with a predisposition to arrhythmia. Impairment in left ventricular (LV) expansion or compliance and LV filling in fibrotic PKD hearts resulted in diastolic dysfunction. LV systolic contractility and elastance decreased in fibrotic PKD …
-
FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both …
Page 1 of 3