Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Diastolic Function"”.
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Kinematic Modeling of the Determinants of Diastolic Function
… clinical cardiology to determine cardiovascular function, and many of the indexes derived from these modalities are causally interconnected. A correlative approach to cardiovascular function however, where indexes are correlated to disease presence and progression, fails to fully capitalize on …
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Cardiac Autonomic Assessment and Diastolic Function in Individuals with Spinal Cord Injury
… index (QTVI) as a measure of cardiac autonomic function in individuals with spinal cord injury (SCI). The secondary purpose was to investigate the influence of cardiac autonomic activity and blood volume on diastolic function in individuals with SCI. Results from Study 1 showed that the QTVI …
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The Effect of Preload Reduction on Parameters to Evaluate Left Ventricular Diastolic Function
… condition. The mitral annulus velocity and early diastolic flow propagation velocity(Vp) are known to be relatively load independent. Recently, the time interval between the onsets of mitral inflow and mitral annulus velocity(TE'-E) has been proposed as a new index representing left …
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Left Ventricular Diastolic Function in Adolescents with Overweight and Obesity: The Moderating Influence of Physical Activity, Cardiorespiratory Fitness, and Metabolic Health
Lifelong preservation of left ventricular diastolic function (LVDF) is an important goal for reducing the burden of diastolic heart failure and related adverse health outcomes. LVDF is strongly linked with obesity. The global obesity pandemic has already increased the burden of diastolic heart …
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Modulation of Cardiac Titin Stiffness in Physiological and Pathophysiological States
… and contains an I-band spanning region that functions as a molecular spring that develops passive force during diastole. Titin stiffness is modulated both by isoform switching and post-translational modifications including phosphorylation. Modulation of titin stiffness occurs in physiological …
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Assessment of Cardiac Function by Acoustic Radiation Force (ARF) Based Methods of Ultrasound Elastography
… is characterized by compromised systolic and/or diastolic function of the myocardium that reduces the pumping and/or filling efficiency resulting in diminished cardiac output. Cardiovascular researchers have been attempting to develop tools for assessment of cardiac function for decades. …
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Kinematic Characterization of Left Ventricular Chamber Stiffness and Relaxation
… most common cause of hospitalization today, and diastolic heart failure accounts for 40-50% of cases. Therefore, it is critical to identify diastolic dysfunction at a subclinical stage so that appropriate therapy can be administered before ventricular function is further, and perhaps irreversibly …
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Aortic Valve Replacement: The Influence of Prosthesis-Patient Mismatch for Left Ventricular Remodeling, Cardiac Function and Survival
… with respect to recovery of left ventricular diastolic function and left ventricular mass regression, and to evaluate the influence of prosthesis-patient mismatch on left ventricular remodeling following aortic valve replacement for severe valve insufficiency. The present work demonstrated …
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Nitrates and Left Ventricular Dysfunction
… with evidence of left ventricular (LV) dysfunction after acute myocardial infarction (AMI) already treated with standard heart failure (HF) therapy. Paper I. In a randomized, double-blind, placebo controlled trial, we evaluated the effects of a 60 mg dose of isosorbide-5-mononitrate …
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Cardiovascular disease risk in children : 'pre-clinical' markers and the impact of body composition, physical activity and cardiorespiratory fitness
… load such as left ventricular (LV) mass, diastolic function and carotid intima-media thickness( cIMT). Further, assessing the association of these markers to other risk factors and then determining the impact of physical activity (PA) interventions is warranted. Initially we assessed the …
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Rapid Magnetic Resonance Imaging of Tissue Motion with Adaptive Velocity Sensitivity for Evaluating Cardiovascular Function
… clinical application of DEPC in evaluating diastolic function from the simultaneous measurement of peak blood (E) and myocardial tissue (Em) velocities - which can differ by an order of magnitude. The response of the magnitude of an MR signal to tissue motion was investigated using theory, …
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Sex dimorphism in the cardiometabolic effects of the smoothelin-like 1 protein deletion in an ageing mouse model
… myogenic response, endothelial barrier function, and inflammatory responses. Vascular function is known to reciprocally influence cardiac function, with impaired diastole and left ventricular (LV) stiffness causally linked to endothelial dysfunction and coronary microvascular …
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Metabolic alterations in patients with heart disease
… widespread abnormalities of both systolic and diastolic function in HCM patients. These abnormalities contribute significantly to exercise limitation observed in these patients. Furthermore, we showed that HCM manifest a myocardial energy defieciency which was accompanied by a slowing of the …
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The effect of prolonged exercise and environmental temperature upon left ventricular function and cardiac biomarker release
… temperature challenge upon left ventricular (LV) function and cardiac biomarker release. The primary aims were; (1) does repeated exercise bouts mediate a cumulative decrease in LV function and/or increase in cardiac biomarker concentrations; and (2) to examine the impact of prolonged exercise in …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… describes distinct structural and functional changes in the heart driven by metabolic and microvascular abnormalities. Microvascular dysfunction appears at an early stage as a result of impaired endothelial function, at least in part due to hyperglycaemia-induced production of …
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The impact of ageing and exercise training on cardiac structure and function in healthy females
… With ageing comes a significant reduction in functional capacity, cardiovascular function, increased cardiovascular disease risk and thus increasing health care costs. Exercise interventions in the elderly may prove to be a valuable tool in coping with an ageing population. It was, therefore, …
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L'attività motoria acquatica come nuovo approccio terapico alla cardio-diabetologia
… anthropometric and lipidemic profile, and diastolic function) and an increasing in quality of life and physical activity levels (Sf-36, PAID, energy expenditure in general physical activity). Discussion: Our findings showed that structured and supervised physical activity performed in …
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Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
… Work from our lab has discovered that a loss-offunction mutation in SHP2 improves heart function after transverse aortic banding. I hypothesized that expression of a loss-of-function mutant SHP2 will improve heart function in DMD mice. To test this hypothesis, DMD mice (mdx4CV) were crossed with …
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Staged surgical palliation and ventricular performance in functionally single ventricle anatomy
… effect of surgical palliation on ventricular function in children with functionally single ventricle anatomy. Ventricular volume and pressure were measured using a combined pressure-conductance catheter. Initial laboratory-based experiments were performed using a physical model of the left …
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