Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Diamide"”.
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Diamino diamide copper complexes as anti-arthritic agents
… the investigation of a series of diamino diamide copper(II) complexes with respect to their potential as anti-inflammatory agents in the treatment of rheumatoid arthritis. Several physico-chemical techniques were employed in the investigation including glass electrode potentiometry, UV/VIS …
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Thermodynamic properties of diamino-diamide ligand as potential anti-inflammatory agent
… weight ligand, 3,5-bis[(aminoethyl)ethanediamideJ-4-oxahexacyclododecane (PCUA) was investigated using glass electrode potentiometry, UV/Visible spectroscopy, nuclear magnetic resonance spectroscopy, speciation modelling as well as blood plasma modelling.
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Syntheses of mono- and diamide cross -bridged cyclens and syntheses of bifunctional chelators based upon cross -bridged tetraamine macrocycles
<p>The syntheses of two diamide cross-bridged cyclens (22 and 23) and three monoamide cross-bridged cyclens (24, 25, and 26) are presented. Metal (Li(I), Zn(II), and Cu(II)) coordination studies of 26 are also presented. Evidence suggests that ligand 26 forms intermolecular complexes through the …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… Ca2+ signaling processes is not well understood. Diamide, a membrane-permeable oxidizing reagent, rapidly and reversibly converts glutathione (GSH) to its disulfide (GSSG), and promotes glutathionylation. In the present Dissertation, the acute effect of diamide on the [Ca2+]i of cultured aortic …
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Investigation of the potential bacterial proteasome homologue Anbu
… conditions including the oxidative stress of diamide and the nitrosative stress of S-nitrosoglutathione. Growth rates were monitored in an attempt to detect a phenotypic difference between the wild type and the mutants lacking Anbu, HslV, and the other proteins of interest. While a substrate …
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A role for glutathione in reactions between oxidants and proteins
… H-Ras on at least one cysteine, while either diamide + GSH or glutathione disulfide (GSSG) was found to S-glutathiolate at least two H-Ras cysteines. The NO donor S-nitrosoglutathione caused S-nitrosylation of H-Ras on four cysteine residues;Within NIH/3T3 cells overexpressing H-Ras, H-Ras was …
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Chiral phosphine synthesis by the application of directed metallation
… of N,N,N',N'-tetramethyl-P-phenylphosphonic diamide (10) led to the interesting primary phosphine, 2-(diphenylphosphino)phenylphosphine (14), after elaboration of the phosphonic diamide directing group. This primary phosphine undergoes an unprecedented facile phenyl group exchange process …
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Synthesis of Group (lV) Transition Metal Complexes and their Applications as Catalysts for Ethylene Polymerization
… complexes in good yields. Asymmetric chelating diamide complexes of titanium and zirconium were also synthesized and tested for ethylene polymerization as a part of the project. Reaction of the desired aniline with an appropriate dibromoalkane compound affords the N-substituted bromoalkyl …
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Toxicity of Formulated Insecticide Mixtures to Apis and Non-Apis Bees
… onsets of mortality, while those comprised of diamide, molting hormone agonist and spinosyn chemistries were relatively less toxic, inducing a slower onset of mortality. At 96-hours, overall high mortality was observed for all treatments, thereby indicating the high acute toxicity of these …
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Development of an antirheumatic drug
The diamino-diamide ligands have been investigated in an attempt to develop an antirheumatic drug. The ligands N,N'-di-(2-dimethylamino)ethyloxamide and N,N'di-(2-diethylamino)ethyloxamide, were synthesised and characterised using the physical techniques, NMR, mass- and infrared spectrometry. The …
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Identifying mechanisms of pyrethroid resistance in the navel orangeworm and novel methods of control
… adjuvants to synergize the toxicity of two diamide insecticides registered at the time for A. transitella control. Despite widespread adoption of insecticide sprays for A. transitella control, the potential toxicity of adjuvants applied in combination with insecticides is unknown. In these …
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Early transitional metal alkyl, alkylidene, and alkylidyne chemistry
… and hafnium complexes of several new unsymmetric diamide ligands have been prepared and their proficiency in olefin polymerization reactions evaluated. The first set of supporting ligands examined are diamido-donor ligands that contain ethylene/o-phenylene "arms" and a phenyl-substituted amine …
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Triphenylene as a Scaffold for New Molecular Materials
… controlled conditions. The corresponding diamide was synthesised to allow for full characterisation, as the diamine was found to decompose rapidly. Crystals were grown of the diamide and the x-ray structure was obtained, this showed an unexpected structure. The expected 3,6-substitution …
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Development of nitrogen protecting groups and synthesis and complexation of bridged bis-tetraazamacrocycles
… and zinc (II) complexes of 94a and 90 and the diamide cross-bridged bis-tehaazamacrocycle 105 were also synthesized. These bis-tetraazamacrocycle systems may find use as potential anti-HIV agents or for stem-cell mobilization.</p>
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… gradients of either hydrogen peroxide (H2O2) or diamide (DIA) with/without Sema3A after first monitoring the initial effects of the treatments using spatial light interference microscopy (SLIM) in real time. The effects of reducing conditions on dendritic growth was consistent with the initial …
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Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
… via thiol-specific stresses including cadmium, diamide, and glucose starvation are proteotoxic by monitoring aggregation of an endogenous redox-sensitive model protein. Emerging from the ribosome, newly synthesized cysteine-containing peptides are in a reduced state. Exposure to thiol-specific …
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Effects of an insecticide/fungicide mixture on queen rearing behavior and hypopharyngeal gland morphology in honey bees (Apis mellifera L.) (Hymenoptera: Apidae)
… Central Valley routinely use tank mixes of the diamide insecticide chlorantraniliprole and the triazole fungicide propiconazole for pest management during bloom. Although this mix is considered safe for honey bees, I investigated possible sublethal effects on the nursing behavior and …
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Functional Characterisation of the Eukaryotic Translation Elongation Factor 1Bγ in Aspergillus fumigatus; A Proteomic Systems Approach
… to the oxidants H2O2 (> 1 mM) (p = 0.0003), diamide (> 0.5 mM) (p < 0.001), and 4, 4’-dithiodipyridine (> 7.5 μM) (p = 0.0056), and was significantly more resistant to voriconazole (> 0.5 μg/ml) (p = 0.0251) than the wild-type. Comparative proteomics, under basal and oxidative stress …
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Redox Regulation of Type Iα PKA in the Heart
… ventricular myocytes (ARVMs) pre-treatment with diamide (inducing disulfide) potentiated isoprenaline-induced cardiac Troponin I phosphorylation. Inhibition of monoamine oxidase (MAO), which metabolises monoamines to generate hydrogen peroxide (H2O2), blocked monoamine-induced RIα oxidation. …
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Palmitoylation and Glutathionylation of Key Sarcolemmal Signalling Proteins in Cardiac Muscle
… G protein a subunits is disrupted following an diamide induced increase in glutathionylation. However, sucrose gradient fractionation reveals no gross change in localisation within the caveolae, suggesting caveolae are still intact. Ischemia Reperfusion (IR) decreases palmitoylation and …
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