Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Diagnostic biomarkers"”.
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New predictive and diagnostic biomarkers for preeclampsia
… that HbF, A1M and Hpx can be used as predictive biomarkers as early as the first trimester with 60% prediction rate at 5% false positive rate. The results in paper III and IV indicate that the constant increased level of HbF strain the scavenging proteins and gradually deplete them. The HbF …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
… (CATT), which has severe limitations. Other diagnostic tests for <em>T. b. gambiense</em> and <em>T. b. rhodesiense</em> infections require lab based equipment, trained personnel and have varying degrees of sensitivity and specificity. New approaches are needed, firstly to identify new …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
Recent studies emphasized the role of leptin/leptin receptor (LEP/LEPR) in normal and inflammatory conditions of dental pulp tissues. LEP/LEPR activity is linked to potential immunomodulation responses during bacterial-induced inflammatory conditions. Additionally, there is substantial association …
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Dilemmas in the pathological diagnosis of rare soft tissue tumors: classical and novel diagnostic biomarkers and emerging concepts
Contains fulltext : 325512.pdf (Publisher’s version ) (Open Access)
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Novel urinary and serological markers of prostate cancer using proteomics techniques: an important tool for early cancer diagnosis and treatment monitoring
… specific antigen (PSA) is presently fraught with diagnostic inaccuracies. Not least, in a multi-ethnic society like South Africa, proteome differences between African, Caucasian and Mixed-Ancestry PCa patients are largely unknown. Hence, discovery and validation of affordable, non-invasive and …
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Detection of mycobacterial siderophores and implications for diagnostics
… regarding the potential use of siderophores as diagnostic biomarkers for TB.
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Proteomics as a tool for the characterisation of nosocomial pathogens
… that intracellular proteins were the new diagnostic biomarkers.
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Biomarkers for Personalised Treatment Approach in Patients with Multiple Myeloma // Биомаркери за персонализиран подход при подбора на лечение при пациенти с миеломна болест
… the role of circulating microRNAs (miRs) as diagnostic and prognostic biomarkers in multiple myeloma (MM). The cohort includes 56 untreated MM patients and 12 healthy controls, with a focus on the quantitative determination of expression levels of five selected miRs: miR-199a-5p, miR-126-5p, …
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Curcumin as a therapeutic agent for the treatment of rheumatoid arthritis and cancer
… agent whilst identifying potential therapeutic biomarkers for the treatment of these inflammatory conditions. HFLS-RA cells were treated with curcumin and MTX, individually and in combination. The novel finding from this study highlighted that individual treatment with curcumin was the most …
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MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy
… lack of disease-specific symptoms and reliable diagnostic biomarkers. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19-9 (CA 19-9) is the most common diagnostic biomarker; …
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Identification of surface accessible proteins in parasitic nematode extracellular vesicles
… chronic infection, parasitic EVs are potential biomarkers of infection due to the species, sex, and life stage specificity of their cargo and structural composition. The exploitation of parasite EVs as a novel diagnostic tool is of particular importance in controlling parasitic nematode …
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To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)
… the need for early diagnosis and effective biomarkers capable of detecting these diseases at early, potentially reversible stages. MicroRNAs have been proposed as potential early diagnostic biomarkers of asbestos-related LC and MPM. miRNAs regulate post-transcriptional gene expression in …
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Krūties vėžio magnetinio rezonanso vaizdo tekstūros analizė /
… could develop new non-invasive breast cancer diagnostic approaches, oriented at genetics. Methods: A prospective analysis of MRI radiomic features and genetic data from 42 patients diagnosed with invasive ductal carcinoma was performed. The cohort was evenly split between patients with BRCA …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… particularly beneficial for the development of diagnostic biomarkers and therapeutic interventions for chronic wounds and metastatic cancers.</p>
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Metabolomics of cerebrospinal fluids to identity novel biomarkers as a predictive tool for brain inflammatory conditions
… significant interest in the investigation of biomarkers to define neuroinflammation and explore mechanisms involved in the regulation of central nervous system immune responses. Metabolomics is a rapidly emerging research field increasingly recognised as a powerful approach for addressing the …
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Cirkuliuojančių prostatos vėžio imuninių veiksnių prognostinis vaidmuo /
… suggest that these molecules may be useful as diagnostic biomarkers and that sPD-L1 proteins in the blood of prostate cancer patients may be a marker of disease aggressiveness.
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Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy
… the utility of nucleic acid modifications as diagnostic biomarkers. Finally, we investigated the effect of the common, transferable bacterial DNA modification phosphorothioation on oxidative and antibiotic stress responses in several pathogens. We showed that phosphorothioation can reduce the …
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Functional genomics studies of human brain development and implications for autism spectrum disorder
… elusive, hampering attempts to develop common diagnostic biomarkers or treatments for this disorder. I hypothesized that analyzing functional genomics relationships among ASD candidate genes during normal human brain development would provide insight into common cellular and molecular pathways …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
… may also contribute to the identification of diagnostic biomarkers for premalignant infections at risk of progressing to cervical cancer. We identified a splicing silencer that interacts with hnRNP D proteins and hnRNP A2/B1 to suppress HPV-16 late gene expression in mitotic cells, including …
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