Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Diagnostic and therapeutic applications"”.
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Engineering M13 Bacteriophage Nanoplatforms for Diagnostic and Therapeutic Applications
… multifunctional nanostructure, consists of thousands of distinct protein subunits organized in a filamentous viral capsid; 900nm in length and 6nm in diameter. All M13 capsids are amenable to mutation and can be tuned for the binding and nucleation of inorganics and nanoparticles, and for the …
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Bioinspired functional DNA-nanomaterial conjugates for diagnostic and therapeutic applications
… of the interface between chemistry, biology, and materials science not only advances the fundamental understandings of phenomena and materials at the nanoscale regime, but also produces novel functional materials with promising applications. Nanomaterials with size similar to biological …
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Improving Bacterial Therapeutics and Diagnostics through Synthetic Biology
… protein production, enabling the diagnosis and treatment of numerous diseases. However, translation to clinical applications still requires concurrent efforts to enhance tunability, specificity, efficacy, and safety. Our work contributes to three such areas. First, we performed model-guided …
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Measurement of the Nonlinearity Parameter B/a in Biological Materials Using the Finite Amplitude and Thermodynamic Method
… in biological materials, including tissue models and soft tissue. An acoustic method with the potential for in vivo measurements is developed for this purpose. The result of measurements is confirmed by a second method which determines the change of sound speed, and hence the compressibility, with …
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Exhaled breath analysis using laser absorption spectroscopy
… sensing is a rapidly developing field, with many applications in breath diagnostics and therapeutic monitoring. For this thesis, laser spectroscopic techniques were employed to measure exhaled nitric oxide (NO), carbonyl sulfide (OCS) and carbon dioxide (CO2). A pulsed quantum cascade laser …
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Understanding The Physics Of Magnetic Nanoparticles And Their Applications In The Biomedical Field
… potential uses in magnetic-recording, medical diagnostic and therapeutic applications. Additionally, they also offer an opportunity to understand the physics underlying the complex behavior exhibited by these materials. Two of the most important relaxation phenomena occurring in magnetic …
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Toxicity and drug delivery ability of bio-inspired silica nanoparticles
… are already being used for a number of diagnostic and therapeutic applications. This work focused on the use of bio-inspired silica as a potential drug delivery agent and the toxic effect produced due to their small size. Using two bio-inspired drug encapsulation methods and a range of …
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Synthesis, Characterisation and Biological Activity of Silicon Nanoparticles Functionalised by Anticancer Compounds
… particularly suitable for various biomedical applications. They exhibit unique optical properties for use in bioimaging and diagnostic applications. To exploit these aspects, this thesis explores the synthesis, characterisation and biological activity of SiNPs functionalised by anticancer …
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Engineering and characterisation of anti-progesterone OBodies
… of an organism. These interactions can be weak and transient or strong and semi-permanent. In the case of the adaptive immune system, strong interactions between foreign antigens and specific antibodies lead to a cascade of events comprising the immune response. This phenomenon has been …
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Novel Cell Penetrating Peptides Effect Endosomal Escape and Deliver Protein Cargos into Living Cells
… that allows any user-defined cargo delivery and release into the cytoplasm. Our hypothesis<strong> </strong>is that a CPP-adaptor with a moiety allowing high-affinity but reversible non-covalent cargo binding would lead to more efficient penetration and release than current CPP delivery …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
Alzheimer's and Parkinson's diseases (AD and PD) are the most common neurodegenerative disorders, affecting millions of patients worldwide with a lack of disease-modifying treatments currently available. These diseases are characterised by the deposition of protein aggregates, which originate from …
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The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
… selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) based diagnostic and therapeutic applications. Bimetallic gold-platinum nanoparticles (AuPtNPs) have …
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NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
… one of the leading causes of death worldwide, and the development of novel immunotherapeutic strategies, such as that of immune checkpoint inhibitors (ICIs), has generated long-lasting responses in multiple malignancies. Even though safer than chemotherapies, some adverse events, including rare …
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Chemomechanics of attached and suspended cells
… con- text of the attached (substratum-adhered) and the suspended (free-floating) states. These dichotomous configurations determine behavioral differences and commonalities relevant to therapeutic reimplantation of stem cells and to our general under- standing of the cell as an animate material. …
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Establishment of recombinant antibody technologies allowing for the generation of SNAP-tag fusion proteins
… breast cancer (TNBC's) is a highly aggressive and invasive subtype of breast cancer, typically characterised by the lack of estrogen receptor (ER), progesterone receptor (PR) and Human epidermal growth factor receptor 2 (HER2) with an inexplicable partiality towards African women. The acute …