Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Diacylglycerol Kinase"”.
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Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase
… RhoGDI. For example, our laboratory showed that diacylglycerol kinase zeta (DGKz), which converts diacylglycerol (DAG) to phosphatidic acid (PA), activates PAK1-mediated RhoGDI phosphorylation on Ser-101/174, causing selective Rac1 release and activation. Phosphorylation of RhoGDI on Ser-34 by …
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Biochemical and physiological studies of Arabidopsis thaliana Diacylglycerol Kinase 7 (AtDGK7)
A family of diacylglycerol kinases (DGK) phosphorylates the substrate diacylglycerol (DAG) to generate phosphatidic acid (PA) . Both molecules, DAG and PA, are involved in signal transduction pathways. In the model plant Arabidopsis thaliana, seven candidate genes (named AtDGK1 to AtDGK7) code for …
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The Immunomodulatory Functions Of Diacylglycerol Kinase Zeta On Type 2 Immune Responses
… Weak TCR-mediated extracellular signal-regulated kinase (ERK) signals are thought to promote Th2 differentiation in vitro. However, it was unclear whether selective enhancement of specific TCR-mediated signal transduction pathways could suppress Th2 differentiation in vitro and block Th2 …
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Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis
… drug library. We identified that ritanserin, a diacylglycerol kinase alpha (DGKA) inhibitor, synergizes with Chloroquine (CQ) to selectively inhibit proliferation of TSC2-deficient mouse embryonic fibroblasts (MEFs) compared to TSC2+/+ MEFs. OBJECTIVE: We hypothesized that TSC2-deficient cells …
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The role of the Dgk1 and Pah1 in lipid interconversion on saccharomyces cerevisiae vacuole physiology, homeostasis, protein sorting and fusion
… (PA) phosphatase gene Pah1, which converts PA in diacylglycerol kinase (DAG), was previously shown to produce a fragmented vacuole phenotype, greatly inhibit fusion and result in the vacuolar protein sorting defect. As such, the impact of the deletion of the complementary DAG kinase gene Dgk1, …
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Amphiphilic gold nanoparticle-based cytosolic drug delivery platform for cancer and infections
… is immunosuppression. Deregulation of cytosolic kinases negatively alters immune cell signaling, proliferation, differentiation, and migration. Small molecule kinase inhibitors offer unique opportunities to enhance anti-tumor immunity by inhibition of immunosuppressive kinases. However, potent …
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The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer
… (DOPC) liposomes containing diacylglycerol kinase (DGK) in order to assess the effect of photoisomerisation of the azobenzene group on the activity of the protein. The increase in volume of bis-Azo-PC in the cis state should have a significant effect on protein activity as …
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Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… of cell growth and metabolism. By virtue of its kinase ability, mTOR has been shown to initiate signaling in response to a variety of extracellular signals including cytokines, growth factors, amino acids, and toll-like receptor (TLR) ligands. The versatility with which this protein kinase …
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Structural studies of putative general stress and related proteins from Deinococcus radiodurans
… encode an undecaprenyl diphosphatase (UDP) and a diacylglycerol kinase (DGKA) were successfully cloned in to pET-28b, with incorporation of separate N- and C- terminal 6xHis tags.