Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Diabetic drugs"”.
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Synthesis of sulfonylthioureas as anti-diabetic drugs
… sulfonylthiourea can potentially be used as anti-diabetic agents.
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Synthesis of Glitazone Analogues as Anti-Diabetic Drugs
… compounds, 36f exhibited excellent antidiabetic activities against α-glucosidase. Compounds 36a, 36b, 36i and 36j also displayed good activities and have potential to be further investigated whereas compounds 36c, 36e, 36g and 36h exhibited moderated activities against α-glucosidase. …
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Drug repurposing : design, emulation and analysis of synthetic in-silico clinical trials using electronic health records and modern data analytics
… advances remains high. As effective anti-cancer drugs are in high demands, drug repurposing, using existing drugs for other diseases has sparked a growing interest. Drug repurposing presents a striking opportunity and potentially significant cost-saving in the future treatment of cancer. The cost …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… less than one in four patients treated with anti-diabetic drugs achieved the glycemic target. Thus, identifying more effective anti-diabetic drugs is still needed for improving glycemic control in T2D patients. Incretins are gut hormones that possess potent insulinotropic action, which have drawn …
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Identification of genipin as a potential treatment for type 2 diabetes
… treating T2D. However, most of the GLP-1-based drugs are expensive and have significant adverse effects. Therefore, development of safer and more convenient agents that can mimic the physiologically fed state to promote endogenous GLP-1 secretory function of intestinal L-cells to improve glucose …
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Anti-diabetic properties of GUH
Objective: To investigate anti-diabetic properties of the plant extract known as GUH in comparison to commercially available drugs metformin and rosiglitazone. Methods: Male Wistar rats were fed a maintenance diet (MD) with tap water or a high fat diet (HFD) with sucrose solution for a period of …
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… target of the thiazolidinedione class of anti-diabetic drugs. Adipose inhibits PPARgamma function by directly binding Med23, a component of the Mediator Complex, which connects transcription factors with RNA polymerase II. Taken together, I have shown that both the Hh and Adp pathway have …
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Diabetes and Obesity Induce Transcriptomic and Metabolomic Changes Enhancing Pancreatic Cancer Aggressiveness
… conditions. Also, we studied the effect of anti-diabetic drugs, particularly metformin and rosiglitazone on pancreatic cancer. We established orthotopic/syngeneic mouse models to evaluate the effect of obesity (<em>A<sup>y</sup>/a</em>) and diabetes (<em>Lepr<sup>db</sup>/Lepr<sup>db</sup></em>) …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… cardiovascular disease (CVD). In fact, new anti-diabetic drugs that do not display undesirable side effects, such as hepatotoxicity, edema and weight gain, are in great demand. For these reasons, the overall goal of this study was centered on four molecular targets: peroxisome …
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The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
… Diabetes Mellitus (T2DM) include a range of anti-diabetic drugs, supplemented by lifestyle modifications to reduce dietary fat intake and body fat. However, for their anti-diabetic action, most drugs recruit insulin signaling pathways, which are already impaired in T2DM. Also, compliance and …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… cells of the pancreas, thereby worsening the diabetic state. Current treatment regimen for DM comprises self-care and anti-diabetic drugs such as biguanides (metformin), thiazolidinediones and sulfonylureas. Metformin is currently the most commonly used antidiabetic drug. However, due to the …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… the interactions between insulin sensitizing drugs, the enzyme AMPK and both the human vascular endothelium and adipose. Further work leading to an increased understanding of the molecular mechanisms by which anti-diabetic drugs activate AMPK in both the vascular endothelium and adipose tissue …
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Causal Inference with Survival Outcomes via Orthogonal Statistical Learning
… to compare the effects of two first-line anti-diabetic drugs on cancer outcomes. Second, a wide range of machine learning methods (or ”learners”) for estimating heterogeneous treatment effects were not applicable to estimating effects on survival outcomes, particularly in the presence of …
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Phytochemical and biological investigation of Lathyrus linofilius as a possible treatment in diabesity
… Therefore, there is a need for improved anti-diabetic drugs with fewer sideeffects to enhance patient compliance and to control blood glucose levels more tightly.Natural products and plants in particular, offer an alternative to syntheticdrugs. Lathyrus linifolius is a plant whose tubers have …