Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Diabetic Nephropathy"”.
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Soy Protein Consumption in Diabetic Nephropathy and Coronary Heart Disease
… positively affect risk factors of CHD in type 2 diabetic patients. Thus, the consumption of soy protein products may constitute an important dietary modification for type 2 diabetic patients. In particular, diets with soy protein at higher protein intakes (∼1.4 g/kg/d in human study) may …
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Identification of factors associated with and preventative strategies in diabetic nephropathy
… of preventative strategies in the treatment of diabetic nephropathy from data collected at nephrological out-patient follow-up visits. A study of mortality, over a ten year period, in 1,421 diabetic and 26,990 non-diabetic people in Wolverhampton identified cardiovascular disease as the …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… cells (MG) and streptozotocin (STZ)-diabetic rat kidneys. In situ hybridization, RT-PCR, RealTime RT-PCR, and Northern blot were used to study mRNA, and immunohistochemistry and Western blot for protein. IP mRNA was detected in glomeruli, vasculature, and cortical and medullary …
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Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
Diabetic Kidney Disease (DKD) is a major complication of diabetes. Incomplete understanding of its molecular mechanisms is highlighted by the limited treatments options. We hypothesized that inhibition of protective endogenous mechanisms plays major role in the pathogenesis of DKD. While …
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Therapeutic Effect of a triterpenic Acid from Protorhus longifolia Against High Fat Diet Fed and Streptozotocin-induced Diabetic Nephropathy in Rats
Diabetic nephropathy (DN) is the major and most frequent complication of diabetes mellitus that contributes to high rate of morbidity and mortality worldwide. Despite the current available treatment regimes, DN still remains the main leading cause of end stage kidney disease. Therefore, more focus …
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The Prediction Model of Disease Progression of Micro and Macro-complication in Diabetes Mellitus
… complication model is as follows : First, diabetic retinopathy model was defined as no retinopathy, nonprofilerative retinopathy, profilerative retinopathy, macular edema, and blindness. Second, diabetic nephropathy model was defined as microalbuminuria, clinical nephropathy, end-stage …
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Significance of active site residues in the n-domain selectivity of angiotensin-converting enzyme
… in the treatment of cardiovascular disease and diabetic nephropathy. Somatic ACE consists of two homologous catalytically active domains (designated N- and C-domains) that share high overall sequence identity and structural topology. Despite the high degree of similarity between domains, each …
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The Genetics of Type 2 Diabetic End-Stage Renal Disease in African Americans
… This region had been previously linked to diabetic nephropathy in other populations. To identify genes which contribute to T2DM-ESRD in African Americans on chromosome 18q21.1-23, candidate gene analysis, fine mapping, and dense SNP mapping methods were used. Using a candidate gene …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… function and cardiovascular pathologies. Diabetic nephropathy is a very common complication in which tubulointerstitial fibrosis may arise from epithelial to mesenchymal transition (EMT) of the proximal tubules cells. Advanced glycated end product (AGEs) including methylglyoxal-modified …
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Clinical characteristics of end stage renal disease patients at hemodialysis initiation
… December 2012. The most common cause of ESRD was diabetic nephropathy (48.7%), followed by biopsy-proven glomerulonephritis (11.7%). The mean eGFR at the start of hemodialysis, ranging between 5.59 – 7.82 ml/min/1.73m2 (except Nankivell equation), were significantly different according to …
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Enhancing the Data, Information and Knowledge from Proteomics Experiments through Biomedical Informatics
… traumatic brain injury, Alzheimer’s disease and diabetic nephropathy and the discovered knowledge and understanding is discussed. Also, parametric and non-parametric statistical methods for assigning significance are applied here to determine the key proteomic changes between proteomes and …
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Early Outgrowth Cells As A Novel Therapy for Chronic Kidney Disease
… (SNX) rat, a well-established model of non-diabetic progressive CKD, and anti-fibrotic and anti-oxidant effects in the db/db mouse, a commonly used model of type 2 diabetic nephropathy. In the SNX rat, which is characterized by impaired cardiac relaxation reminiscent of a common and high …
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Vasogenic bloodborne progenitors and diabetes
… those which affect the vascular system, such as diabetic nephropathy, neuropathy and retinopathy. Of these, diabetic retinopathy (DR) is the most common, and it remains a leading cause of vision loss in adults between the ages of 20-74.<br/><br/>Underlying these vasodegenerative pathologies is a …
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Record review of post-haemodialysis blood results to assess adherence to guidelines for end stage renal disease
… as Coloured. Most patients (55/169, 32.54%) had Diabetic Nephropathy. Suboptimal dialysis adequacy (Kt/V levels) was present in 86/133 (64.6%) of the patients, similarly 102/166 (62.5%) for serum phosphate. Arterio-venous fistula or graft is recommended for vascular access for HD and 112/169 …
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Evaluation of Genetic Variants Influencing Susceptibility to Type 2 Diabetes Associated End-Stage Kidney Disease and Associated Phenotypes
… and prevalence of T2D-ESKD, in addition to non-diabetic forms of ESKD, are markedly higher in African Americans compared to all other ethnicities even after adjustment for socioeconomic factors. Familial aggregation studies also support a strong genetic component to T2D-ESKD in African …
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