Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Dextromethorphan"”.
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… in treating OCD. One drug in particular, dextromethorphan (DM), provides antidepressant-like effects by possibly inhibiting glutamate and activating sigma-1 receptors. Common preclinical approaches for screening experimental OCD drugs include the marble-burying test (MBT) for compulsive …
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Effects of NMDA Receptor Antagonists on the Differential-Reinforcement-of-Low-Rate 72 Second (DRL 72) Responding in Rats
<p>The noncompetitive NMDA receptor antagonist dextromethorphan and its metabolite dextrorphan have widespread effects on the central nervous system. Dextromethorphan alone and with quinidine (a CYP-450 2D6 inhibitor) have been shown to produce antidepressant effects in preclinical and clinical …
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Study on the effects of bitter taste receptor on the rat pulmonary artery
… on rat TAS2R genes. Quinine, denatonium, and dextromethorphan caused a concentration-dependent relaxation of the pulmonary artery pre-contracted with phenylephrine. Removal of endothelium had no effect in the concentration-response curves for quinine, denatonium, and dextromethorphan, …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
… a Western blot assessment was conducted with dextromethorphan, which is a compound that exhibits all three pharmacological actions of interest for this study. The NMDA receptor antagonist S-ketamine, the sigma 1 receptor agonist SA4503, dextromethorphan (after subcutaneous, but not …
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FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
… with four drugs (buspirone, caffeine, dextromethorphan and losartan) used to probe cytochrome P450 (CYP) activities, a significant decrease in fexofenadine AUC was observed without a change in elimination. Based on this observation, I hypothesized a fexofenadine-probe drug interaction …
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Management of treatment resistant depression /
… such as ketamine, psilocybin, buprenorphine, and dextromethorphan and non-pharmacological interventions, encompassing psychotherapeutic methods and brain stimulation techniques like electroconvulsive therapy and repetitive transcranial magnetic stimulation, can be considered when discussing the …
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Does distress predict central sensitisation in people living with HIV?
… studies manipulated the surface area of SH using dextromethorphan alone (n = 8) or combined with morphine (n = 2). Four of those using dextromethorphan alone reported no effect, and the rest reported a decrease in the surface area of SH. Those who combined dextromethorphan with morphine reported …
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CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… and selectively inhibited CYP2D6-mediated dextromethorphan O-demethylation with an IC50 (Ki) value of 3.05 μM (1.24 μM), in a competitive manner. M-1 also markedly inhibited CYP2D6 activity; its inhibitory effect with an IC50 (Ki) value of 0.201 μM (0.120 μM) was more potent than that of …
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Effect of obesity on hepatic drug metabolism
… oxidase, and NAT2 activity using caffeine and dextromethorphan as probe drugs. Our results conclusively indicate that obesity results in an elevation of xanthine oxidase and NAT2 enzyme activities in obese children as compared to lean children, whereas there was no difference in CYP1A2, CYP2D6 …