Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Dexmedetomidine"”.
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Paediatric Dexmedetomidine Pharmacology
Dexmedetomidine is a highly selective alpha-2 adrenoceptor agonist. Use is increasing in the paediatric setting, but without the concomitant understanding of the pharmacokinetics and pharmacodynamics to ensure safe and effective dosing. In this thesis the pharmacokinetics and pharmacodynamics of …
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Perioperative Education on the Utilization of Dexmedetomidine for Surgical Patients
… practitioners’knowledge of the application of dexmedetomidine (DEX), focusing on maximizing patient care during general anesthesia or procedural sedation. Background. The analgesic, sedative, and anxiolytic qualities of DEX, a selective alpha-2 adrenergic agonist, provide exceptional benefits …
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Dexmedetomidine : a phase I study to evaluate the pharmacokinetics and pharmacodynamics in paediatric patients
Includes bibliographical references.
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Closer look at the fMRI data analysis pipeline and its application in anesthesia resting state experiment
… denoising techniques, and application to the Dexmedetomidine experiment data. In the first part, important and confusing resting state data analysis steps are explored indepth, focusing on how and why the pipeline is different from that of the task-based fMRI. In the second part, the Principal …
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Locoregional techniques for dogs undergoing tibial plateau leveling osteotomy : a literature review, anesthesiologist survey, and future directions
… newer graduates prefer the use of bupivacaine-dexmedetomidine for peripheral nerve blocks in dogs undergoing TPLO and that analgesic decision-making in the clinical setting is multi-factorial. Overall, this research demonstrates that while significant advancements have occurred in the …
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Paediatric out-of-theatre procedural sedation at a tertiary children's hospital: A prospective observational study
… cases the intravenous route was utilized, with dexmedetomidine, ketamine and propofol being the three most commonly used agents. Conclusion: 639 PSA events were recorded in 3 months. The 288 events analysed were safely performed with minimal serious reported events. These results compare …
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Cellular and molecular mechanisms underlying anesthetic-induced cytotoxicity, and their impact on learning and memory
… relevant concentrations of sevoflurane and dexmedetomidine (DEX). Specifically, I tested sevoflurane, to determine its effects on cell viability, growth, synapse formation, mitochondrial function and morphology using a variety of morphological and molecular tools. All of the above-mentioned …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… with E, NE, phenylephrine (an α1-AR agonist), dexmedetomidine (an α2-AR agonist), and isoproterenol (a β-AR agonist) modified neutrophil and eosinophil expression of intracellular reactive oxygen species, CD11b, L-selectin, CD16 and CD44. Analysis of these markers revealed significant …
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ANAESTHESIA AND PAIN MANAGEMENT IN COMPANION ANIMALS
… showed that preemptive intra-articular dexmedetomidine, alone or in combination with lidocaine, provided effective intraoperative analgesia in dogs undergoing arthroscopy; treatments also resulted in similar postoperative analgesic effects. In the third and fourth studies we moved to …
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Total intravenous anaesthesia in dogs: development of a target controlled infusion (TCI) scheme for propofol
… medetomidine (MED) and its active enantiomer dexmedetomidine (DEX). The study was divided into 4 phases. In phase one, canine PPF pharmacokinetic (PK) parameters, derived from previous studies reported in the literature, were incorporated to a Target Controlled Infusion (TCI) system. This …
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Usos de dexmedetomidina en broroncoscopia rigida : Fundación Cardioinfantil 2010-2018. Serie de casos
OBJETIVO: Describir el uso de dexmedetomidina asociada a diferentes técnicas anestésica en pacientes que requirieron procedimientos intervencionistas en la vía aérea bajo broncoscopia rígida en la fundación Cardioinfantil, durante los años 2010 – 2018. MÉTODOS: Estudio de serie de casos, se …
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Uso de dexmedetomidina como tratamiento coadyuvante de síndrome de abstinencia alcohólica: revisión sistemática
El objetivo de este estudio es establecer si la dexmedetomidina (DEX) es segura y efectiva para el manejo coadyuvante de síndrome de abstinencia a alcohol (SAA) a través de la búsqueda de evidencia científica. Metodología: se realiza una revisión sistemática de literatura publicada y no publicada …