Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 196 for “"Dexamethasone"”.
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Initiation of Parturition in Dairy Cows with Dexamethasone and Dexamethasone Plus Estradiol Benzoate
… 1) and 26 of 26 (Trial 2) Holstein cows given dexamethasone (Trial 1), 4.4 mg/100 kg body weight, or dexamethasone plus .25 mg estradiol benzoate (Trial 2) at day 273 of gestation. Parturition occurred at 45.l z +/-11.1 h (Trial 1) and 40.8 ± 9.6 h (Trial 2) after injection. Twenty-nine control …
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Prenatal dexamethasone exposure: glucocrticoid programming of the brain
… effects. By using a rat model of prenatal dexamethasone (100μg/kg per day) administered to pregnant dams during the last week of gestation, I found that prenatal dexamethasone overexposure significantly reduced birth weight in both male and female offspring. I also assessed the consequences …
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THE IMPACT OF CYP3A4*22 AND CYP3A5*3 ON DEXAMETHASONE AND 6-HYDROXY-DEXAMETHASONE PHARMACOKINETICS IN PHASE 1/2 CANCER PATIENTS
… pharmacokinetics of various CYP3A4/5 substrates. Dexamethasone is a widely used anti-inflammatory and immunosuppressive agent. In humans, dexamethasone is extensively metabolized by CYP3A4/5 to its major metabolite, 6-hydroxydexamethasone. Pharmacokinetic studies have revealed high inter- and …
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Dexamethasone- and age-sensitive genes in neonatal small intestine
… work indicated that priming the gut with Dexamethasone (Dex, a glucocorticoid analog) allowed fructose to precociously stimulate GLUT5 even in suckling pups < 14 d old. This suggests that the effect of Dex on GLUT5 is similar to the effect of age; both allow fructose to stimulate GLUT5. It …
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Adjunctive use of intravitreal dexamethasone in presumed bacterial endophthalmitis
Includes abstract. Includes bibliographical references (leaves 33-36).
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Effects of Neonatal Dexamethasone on the Maturation and Endowment of Cardiomyocytes
… including respiratory distress syndrome. Dexamethasone, a synthetic glucocorticoid is the ‘gold standard’ intervention in the treatment of preterm infants and mothers at risk of preterm birth because it promotes organ maturation, particularly the lungs and aids in surfactant production. …
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Peripheral Blood Mononuclear Cells Cytokine Expression in Horses Treated with Dexamethasone
… of the study was to evaluate the effect of dexamethasone treatment in horses on mRNA cytokine expression, including interleukin-1Î , interferon-gamma, interleukin-4 and interleukin-6, during a five day treatment period and a five day post treatment period. A randomized complete block design …
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Antidepressant effect of pramipexole in a dexamethasone induced depressive-like behavior model
Resumo: A depressão é um distúrbio psiquiátrico comum caracterizado por diversos sintomas debilitantes como a desesperança e a anedonia. Apesar de a fisiopatologia do distúrbio ainda não estar completamente elucidada, evidências demonstram a associação entre a depressão e disfunções do sistema …
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Analgesic efficacy of caudal dexamethasone combined with ropivacaine in children undergoing orchiopexy
ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF TABLE ⅳ LIST OF FIGURE v Ⅰ. INTRODUCTION 1 Ⅱ. PATIENTS AND METHODS 3 Ⅲ. RESULTS 7 Ⅳ. DISCUSSION 15 Ⅴ. CONCLUSION 21 REFERENCES 22 국문요약 27
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The pathophysiology of chronic subdural haematoma and the role of the dexamethasone
… trial of the potent anti-inflammatory dexamethasone. Blinded interim results of the trial are discussed, but the main focus are the scientific, mechanistic sub-studies. A method for detecting dexamethasone in CSDH and blood was developed using high performance liquid chromatography …
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Effects of in vivo dexamethasone sodium phosphate on in vitro equine neutrophil function
… after administration of a single IV dose of dexamethasone sodium phosphate (0.088 mg/kg) to adult horses. Neutrophils were separated from whole blood using a two-step Percoll gradient. Purified neutrophils from dexamethasone-treated horses had impaired ability to kill Staphylococcus aureus as …
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Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage
The glucocorticoid drug Dexamethasone (Dex) has been proposed as a potential therapeutic to treat or prevent post-traumatic osteoarthritis (PTOA), a disease affecting millions of Americans without a disease-modifying drug. However, current reports on Dex efficacy often disagree on the effects of …
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Investigating the effect of dexamethasone on productivity, immune function, and behavior in dystocic periparturient dairy cattle
… period, we administered either a potent steroid, dexamethasone (DEX), or a saline control (CON) to cows within 12 hours after a dystocic parturition. The inflammatory marker haptoglobin was measured as well as behavioral and production measures. We observed that primiparous DEX cows exhibited a …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
Dexamethasone therapy has been the backbone of myeloma treatment for the last few decades. Despite advances in chemotherapy, myeloma continues to be incurable and all patients eventually relapse with progressive disease. Cell adhesion mediated drug resistance and a permissive bone marrow …
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Transcriptional regulatory elements for basal expression and effects of phenobarbital and dexamethasone onmRNA levels of rabbit CYP2C genes
Cytochrome P450 (CYP) genes, expressed in many species, are involved in the oxidative metabolism of many xenobiotis as well as endogenous compounds. Expression of the rabbit CYP2C1 gene is observed only after induction with phenobarbital and is confined to the liver. The CYP2C2 gene is inducible in …
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The Production and Characterization of Xenopus Albumin Complementary-Dna Clones and Regulation of Rna Levels by Estrogen and Dexamethasone
… regulation of Xenopus albumin by estrogen and dexamethasone, albumin cDNA clones were isolated from an 18S cDNA library produced from uninduced RNA. Several albumin clones were identified and characterized with respect to their restriction maps, and homology to each other. Clones corresponding …
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Modulators of Inflammation and Steroid Receptors Regulate Proteinase Inhibitor 9 Gene Expression
… the synthetic anti-inflammatory glucocorticoid, dexamethasone, induced PI-9 gene expression via an imperfect glucocorticoid response element (GRE) located at -208. Dexamethasone induced PI-9 mRNA and protein. Dexamethasone-glucocorticoid receptor (GR) complex inhibited IL-1beta induced PI-9 gene …
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