Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Developmental signaling"”.
-
Optogenetic control of developmental signaling pathways
… defies simplistic understanding. Yet, embryonic developmental programs use a surprisingly small set of signaling pathways to pattern the embryonic tissue into germ layers from which the various tissues and organs emerge. A hallmark of embryonic development is that these recurring developmental …
-
Developmental signaling pathways in adult energy homeostasis
Many signaling pathways which are classically understood for their roles in early development are also known to be involved in tissue maintenance and adult energy homeostasis. Furthermore, dysfunction of these signaling pathways results in human diseases such as cancer. An in depth understanding of …
-
Activation of developmental signaling pathways in hematopoietic stem cell regeneration
… of this project it was unclear whether the signaling pathways which homeostatically control self renewal are utilized during injury repair. In particular, there is very little understanding of the signals required for regeneration after radiation damage. We hypothesized extracellular signal …
-
Insights into gene regulation by genome structure, phase separation and developmental signaling
… of gene expression is essential to the developmental processes that give rise to hundreds of different cell types with unique cellular identities. Regulation of protein-coding and long non-coding RNA genes by RNA polymerase II is carried out by the coordinated action of transcription …
-
Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
… been implicated in a wide range of cell-cell signaling and cell-matrix interactions. Multiple heparan sulfate (HS)-binding growth factors, such as Wnt, bone morphogenetic proteins (BMP), and fibroblast growth factor (FGF), critically regulate cell fate decisions of ES cells. Here, we showed …
-
Structural Investigations of Porcupine and Dispatched-1 in Wnt and Hedgehog Morphogen Biogenesis
Here, I present the cryo-EM studies in two key developmental signaling pathways, Hedgehog (HH) and Wnt signaling pathways. HH signaling is vital for metazoan development, and its ligand is secreted by a cell surface protein named Dispatched-1 (DISP1). I report the cryo-EM structure of the DISP1 in …
-
Organizer regeneration and patterning of stem cell lineages in planarians
… of performing these tasks in the absence of developmental cues, and in the presence of pre-existing, differentiated tissues. Planarian head regeneration involves the anterior pole, which is a cluster of cells in the tip of head required for proper head patterning. We used transplantation to …
-
New technologies and methodologies for the study of human mammary epithelial differentiation and development
… initiation. Important connections between normal developmental signaling and breast cancer biology are evidenced by the molecular similarities between tumors and normal cell types. Thus, understanding how mammary differentiation is regulated has long been a goal in oncology and developmental …
-
Identification of the Molecular Basis of Morphological Variation in Avian Beaks
… microarrays to analyze the spectrum of developmental signaling pathway and transcription factor gene expression changes in neural crest cells of the developing beaks for the chicken, duck, and quail, both before and after morphological variation is evident. I found that neural crest …
-
Quantitative modeling of spatiotemporal systems: Simulation of biological systems and analysis of error metric effects on model fitting
… have been complemented by dynamic simulations of developmental signaling and genetic interactions. Models provide means to evaluate "emergent" properties of systems sometimes inaccessible by reductionist approaches, making them test beds for biological inference and technological refinement.^ The …
-
Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery
… development of all metazoans, the Hedgehog (Hh) signaling pathway provides instructional cues influencing a variety of cellular processes. The pathway ligand, Hh, is dually lipidated by cholesterol and palmitate, which effectively anchors the molecule to the lipid bilayer of the signal producing …
-
Positional Information in Adult Bilaterian Tissues
… by muscle cells in the form of genes encoding signaling molecules known as positional control genes (PCGs). Positional information in the planarian body is particularly influenced by putative organizer pole cells located at the extreme ends of the anterior-posterior axis. We identified nr4A as …
-
Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… and remodeling of synapses. Defining the signaling pathways that underlie such plasticity has been a major goal of modern neuroscience. BMP signaling critically regulates both morphological plasticity and neurotransmission in motorneurons at the Drosophila neuromuscular junction (NMJ). …
-
Cell Memory and Fate in Human Development
… to many forms of multicellular life. Cell-cell signaling is central to development, particularly in organisms such as vertebrates, where embryonic cells become progressively restricted in their potential through a hierarchy of decision points guided by the signals they receive. All cells contain …