Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Developmental plasticity"”.
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Developmental Plasticity of Language Representation in Healthy Subjects and Children with Medically Intractable Epilepsy
… the role of pathology type on interhemispheric plasticity of language was determined by comparing lateralization in children with developmental, acquired, and tumour pathologies. Findings from 105 consecutive intracarotid sodium amobarbital procedures were retrospectively analyzed, revealing no …
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
… In summary, this study showed PICs have broad developmental plasticity both in vitro and in vivo, and can be propagated and maintained in a primitive state in culture. Furthermore, PW1 also marks a stem cell population within the heart. These data opens new avenues for solid tissue engineering …
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Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans
The genetic study of the C. elegans dauer developmental decision has served as an experimental paradigm for understanding how environmental cues influence organismal physiology through evolutionarily conserved neuroendocrine signaling mechanisms. My genetic characterization of the previously …
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Evolution and Development of Pigmentation Patterns in East African Cichlid fishes
… traits by integrating population genomics and developmental genetics techniques. Using East African cichlid fishes as a model system, I aim to understand the evolutionary origin and diversification of anal fin egg-spots. Egg-spots are an innovation unique to the haplochromine cichlids; yellow …
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The origin of alternative phenotypes in fishes
… and discussing the significance of phenotypic plasticity as an evolutionary process that leads to the expression of alternative phenotypes within a species. Such phenotypic expressions are particularly interesting, because the process by which new species are formed typically involves a …
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LIFE HISTORY SWITCH POINT PLASTICY IN RESPONSE TO POND DRYING ALYERS METAMORPH ALLOMETRY AND JUMPING PERFORMANCE
… by altering life history switch points through developmental plasticity. Pond drying is an important factor which may alter life history switch points in aquatic organisms. Many amphibians can plastically respond to changes in pond drying by emerging earlier, but few studies have examined the …
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Development and plasticity of the functional laminar mesoscale organization of the primary auditory cortex
… this mesoscale organization during different plasticity windows is not known. The work in this dissertation uses in vivo two-photon calcium imaging in mice to investigate how the population dynamics of auditory neurons within thalamorecipient layer 4 and supragranular layers 2/3 change over …
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Maternal diet and programming of embryo and fetal development in the mouse
Plasticity is a prominent feature of early development, and is necessary to allow the fetus in utero to adapt to the continual variation in nutrient and oxygen supply it receives from the mother. In contrast to adaptations made in adult life, those made during fetal life tend to become permanent …
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Identification of Unique Hematopoietic Stem Cell Properties
… in most cases the reported efficiency of such developmental plasticity has been rather low. We demonstrate that HSCs efficiently engraft within the infarcted myocardium following transplantation. However, engraftment is transitory and hematopoietic in nature. Our findings challenge the …
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Investigating the role of a JNK-like MAP kinase signaling in regulating dauer developmental arrest in Caenorhabditis elegans
… anatomic and metabolic remodeling to enter a developmental diapause called dauer in response to crowding, diminished food and elevated ambient temperature. The experimental studies of dauer formation have advanced our understanding of how conserved neuroendocrine signaling regulates …
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Adipose-Derived Stromal Cells Contribute To Spinal Cord Repair But Are Not Neural-Crest Derived Stem Cells
… of adult mammals, and had maintained early developmental plasticity. This hypothesis was not supported by lineage tracing experiments. Additionally, I found that ADAS cells were not capable of differentiating into functional neurons in vitro or in an in vivo model of spinal cord injury. …
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Gene Flow and Dispersal Among Populations of the Stonefly <i>Peltoperla tarteri</i> (Plecoptera: Peltoperlidae) in the Southern Appalachians
… the same time and mating with one another. Such developmental plasticity may allow some individuals to avoid adverse environmental conditions. The extent and likely mechanism of dispersal was determined by comparing levels of population genetic differentiation within drainages to that among …
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Genomic and physiological adaptation to temperature in the invasive golden star runicate (Botryllus schlosseri)
… tolerance at later life stages, establishing developmental plasticity of thermal tolerance. In Chapter 4, I extended my physiological investigation to the west coast of North America, comparing post-larval heat tolerance across three populations spanning a 24.3° latitudinal gradient while …
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Young adults' sexual strategies and mating displays in the virtual world: an evolutionary perspective
… that natural selection favours a degree of developmental plasticity when it comes to sexual strategies and mating displays. Individuals should develop a faster life history strategy (showing, for example, higher mating effort and a preference for a variety of mates) when they are raised in a …
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Genomic and physiological adaptation to temperature in the invasive golden star tunicate (Botryllus schlosseri)
… tolerance at later life stages, establishing developmental plasticity of thermal tolerance. In Chapter 4, I extended my physiological investigation to the west coast of North America, comparing post-larval heat tolerance across three populations spanning a 24.3° latitudinal gradient while …
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The Role of Maternal High Fat Diet in the Pathogenesis of Metabolic and Bone Disease in the Adult Offspring
… the observed metabolic aberrations could include developmental plasticity and mismatch, catch-up growth, and altered programming of the appetite regulatory network. Collectively, this research suggests that early exposure to a fat-rich diet can lead to metabolic and skeletal aberrations in the …
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Investigating the molecular mechanisms of the metabolic syndrome
… di erent time-points to pinpoint the window of developmental plasticity.
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Mechanisms behind the fate of early chromosomal and transcriptional heterogeneities in the mouse embryo
… the principal cause for low human fecundity and developmental defects. However, there is a dramatic decline in the prevalence of aneuploidy as gestation progresses. To understand the fate of aneuploid cells, a mouse model of chromosome mosaicism was used. In vitro culture system and live imaging …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… all major placental cell types. Reflecting this developmental plasticity, trophoblast stem cells (TSCs) can be derived from the TE of mouse blastocysts. TSCs have proven an invaluable research tool to study processes of early placentation in vitro. Despite the placenta’s central role in …
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MtCEP1 peptides regulate lateral organ development in the model legume, Medicago truncatula
… transduction pathways that regulate specific developmental events including meristem development and cellular differentiation. In this thesis, a member of the C- terminally Encoded Peptide (CEP) family of regulatory peptides, MtCEP1, is studied in the model legume, Medicago truncatula, for its …
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