Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"Development pipeline"”.
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Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
… TD natural product discovery and development pipeline that consists of seven steps: 1) soil eDNA extraction; 2) eDNA library construction; 3) homology-based screening; 4) bioinformatics analysis; 5) heterologous expression; 6) characterization of compounds and their biosynthesis; …
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Managing the integration of technology into the product development pipeline
Managing the integration of technology is a complex task in any industry, but especially so in the highly competitive automotive industry. Automakers seek to develop plans to integrate technology into their products such that they deliver significant value to the customer. These plans and their …
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Creating Individual Behavior Change Through 360-Degree Feedback: A Development Pipeline Perspective
… for understanding how efforts toward individual development are restricted. To do this, I used a new 360-degree feedback instrument called “Time 2 Change” that measures self, manager, direct report, and peer/colleague perceptions of change in the individual. This instrument also measures the …
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Hierarchical reinforcement learning for adaptive and autonomous decision-making in robotics
… The ecosystem begins with the creation of a development pipeline which can be used to progressively train Reinforcement Learning Algorithms in increasingly realistic scenarios, culminating with the deployment of these algorithm onto a real system. The pipeline is paired with the novel …
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Equipping and Empowering Biblical Leaders at Bridgeway Church in Oklahoma City, Oklahoma
This project sought to develop a leadership development pipeline at Bridgeway Church in Oklahoma City, Oklahoma to provide clear pathways for concretely and effectively leading attenders from first-time visitor all the way to Great Commission character, competency, and calling. Chapter 1 describes …
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Establishing a Leadership Development Process for Gospel-Centered Multiplication at the Village Church, Flower Mound, Texas
ESTABLISHING A LEADERSHIP DEVELOPMENT PROCESS FOR GOSPEL-CENTERED MULTIPLICATION AT THE VILLAGE CHURCH, FLOWER MOUND, TEXAS Justin Trevor Joy, D.Min. The Southern Baptist Theological Seminary, 2016 Faculty Supervisor: Dr. J. T. English Chapter 1 establishes the goals that encompass this project, …
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Development of a statistical shape and appearance model of the skull from a South African population
… segmentation. This document presents the development of a SSM and a SAM of the human skull from a South African population, using the Scalismo software package. The SSM development pipeline was composed of three steps: 1) Image data segmentation and processing; 2) Development of a …
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Estimating antimalarial drug activity in vivo: an interdisciplinary approach combing novel experimental data with mathematical modelling
… have stalled. There are currently 46 drugs in development by the Medicines for Malaria Venture at different phases of the drug development pipeline. During development, antimalarial drugs are tested in pre-clinical animal models and early-stage clinical trials to determine in vivo drug activity …
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Characterization and rational design of biomolecular sensors using molecular dynamics simulations
… designed using laborious methods limiting development to a small number of applications with large commercial value. To overcome this limitation, computational approaches are needed to streamline rational design of protein-fluorophore conjugate-type biosensors. Here, I report and …
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Getting comfortable in the zone with S3DComfortZone
… a visualization tool integrated into the development pipeline displaying the virtual comfort zones of stereoscopic 3D devices. This tool addresses the need for visualization information of unique comfort zones across multiple stereoscopic 3D devices. The comfort zone is defined as a volume …
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A bioactive peptide from the skin secretion of the Chinese Torrent Frog, Amolops wuyiensis
… could expand the potential drug discovery and development pipeline directed towards alleviation of serine protease-mediated pathologies.<br/>
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Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk
De novo drug development represents an exceedingly complex, time-consuming, and expensive process. Drug repurposing, utilizing large-scale transcriptomic datasets, has emerged as a promising alternative, accelerating the entire drug development pipeline. The recent introduction of single-cell RNA …
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Quantitatively Motivated Model Development Framework: Downstream Analysis Effects of Normalization Strategies
… be no consistent, quantitatively motivated model development framework in data science, and the downstream analysis effects of various modeling choices are not uniformly documented. Examples are provided which illustrate that analytic choices, even if justifiable and statistically valid, have a …
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Manufacturing risk assessment and uncertainty analysis for early stage (Pre-phase III) pharmaceutical drug production
… and to the end consumer, the patient. Physical development, manufacturing and distribution of these drugs, both of biologics and small molecules, is extremely technical in science and processes. Additionally, the industry is highly regulated with nuanced requirements that vary by country of …
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A modular interface framework for multimodal annotations and visualizations in Human-AI collaboration
… of annotated data. The current research and development pipeline involves each group collecting their own datasets using an annotation tool tailored specifically to their needs, followed by a series of engineering efforts in loading other external datasets and developing their own interfaces, …
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Identification and validation of Biomarkers for Breast Cancer from human White Blood Cells
… The main aims of the study were to develop the pipeline to discover and validate novel biomarkers in WBCs of breast cancer patients using proteomic and genomic approaches, and assess these biomarkers’ utility. Using the highthroughput mass spectrometry and 2D-gel-electrophoresis, the protein …
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Identification and Inhibition of Fosfomycin Resistance Enzymes for Structure-Based Drug Design
… duration of care and costs of treatments. The development of new antibiotics to combat bacterial resistance is a long and costly process and has resulted in pharmaceutical companies turning away from the traditional drug development pipeline. One alternative method to address AMR is through …
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User driven product innovation
… there is a need to evolve the innovation development process in parallel to the exponential growth in complexity of the products and the broad ecosystem support that is required to meet user expectations. There are many paths to engage a user community and to obtain end user insights to …
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Essays in pharmaceutical economics
… entry into the pharmaceutical research and development pipeline. I further implement new methods in robustness analysis including specification curve analysis and meta-regression. In the second chapter I examine competition in the research and development-intensive biopharmaceutical …
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