Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Developability"”.
-
Computational pharmaceutics approaches to inform drug developability: focus on lipid-based formulations
… (ML) computational modelling to inform candidate developability. Via prediction of both quality target product profile characteristics and formulation performance indicators for lipid-based formulations (LBF). In recognition of the fact that computational models will not entirely circumvent need …
-
Developability assessments and analytical characterization of recombinant protein antigens formulated as low-cost, multi-dose, aluminum-adjuvanted vaccines
… perspective. In this work, a vaccine formulation developability assessment workflow was established to rapidly screen recombinant protein antigen variants using minimal material to identify optimally stable, low-cost vaccine candidates targeted for use in LMICs. This workflow includes two …
-
Engineering developable miniprotein ligand scaffolds
… compounded by the elusive factors driving their developability – properties like stability and expression that determine a protein’s viability as a product – and evolvability – the capacity to accept mutations necessary for novel function. To tackle this challenge, we evaluated the ability of …
-
Investigating "difficult-to-express" monoclonal antibody frameworks in transient and site-specific integration-based Chinese hamster ovary cell expression systems
… on both its clinical performance and its “developability” profile, a set of characteristics that defines its ability to be manufactured at large-scale using current practices in the biopharmaceutical industry. Failure to identify low developability mAb candidates prior to process …
-
Integrin-independent activation of Tie2 using the de novo designed protein H8mb
… it therapeutically have been limited by the poor developability and receptor promiscuity of Angiopoietin-1 (Ang1), which binds both Tie2 and α5β1 integrin. Here we report the de novo design of a compact Tie2 binding protein that overcomes these constraints. We use RFdiffusion to design a stable, …
-
Determinants of antibody specificity
… and sequence determinants causing this poor developability are unknown, which leads to inexact methods to correct otherwise promising clinical candidates. In this thesis we outline the development of high throughput methods to interrogate developability of candidate antibodies on the surface …
-
Machine Aided Biological Discovery and Design
… develop large libraries optimized for targets or developability characteristics leading to more promising candidates from affinity selection.
-
Rail Rebound: The Impact of Freight Rails on Regional Development in the United States, 1970-2010
… cartographic boundary shapefiles, the land developability index, and decennial censuses of 1970, 1980, 1990, 2000, and 2010. This study utilizes exploratory spatial data analysis, standard regression, and spatial regression models. The application of spatial lag model, spatial error model, …
-
Advancing nanobody discovery and engineering with sequence-based machine learning
… computational strategies to optimise the developability and functionality of engineered nanobodies. First, I present AbNatiV, a deep-learning model for assessing the nativeness of antibodies. It enables the generation of antibodies and nanobodies undistinguishable from immune-system …
-
In silico tools for the development of biotherapeutics
… were combined into a new tool, called the Developability Index, to predict protein aggregation rates. This tool was successfully applied to both antibody and individual antibody domains. The non-enzymatic, acid-catalyzed hydrolysis of an amide bond following an aspartic or glutamic acid …
-
Surface triangulation and the downstream effects on surface flattening
… considered is the influence of triangulation developability and its effects on flattening. Developable surfaces should flatten without inducing any area or shape distortion. However, it is shown that the transfer of this developabilty information from the surface to the triangulation can be …
-
Investigating the Structure and Physical Stability of Glp1-Like Peptides Using Mass Spectrometry
… the difficulty lies in their pharmaceutical developability, and ensuring their fidelity throughout a defined shelf-life. In addition to chemical degradation, physical aggregation of peptides into oligomers and fibrils can compromise the safety, efficacy and bioavailability of peptide …
-
In vitro and in silico profiling to assist pharmaceutical development
… is designed. This is applied in the recent developability classification system (DCS). This classification incorporates an estimate of the fasted intestinal solubility along with the dose/solubility ratio of the drug and allows a better understanding of the factors limiting oral absorption. …
-
The structure, biophysics and bioengineering of secretory immunoglobin A
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01