Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Deubiquitylating enzymes"”.
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… however little is known about their cognate deubiquitylating enzymes (DUBs). A proteomic screen identified the DUBs OTUB1 and USP15 as potential novel regulators of the TGFß and BMP pathways respectively.<br/>Endogenous OTUB1 was recruited to the active phospho-SMAD2/3 complex only upon TGFß …
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Structure function analysis of the deubiquitylating enzyme Fam
… cellular processes. Ubiquitylation is opposed by deubiquitylating enzymes (Dubs), and the ubiquitin specific peptidase (USP) class of Dubs remove ubiquitin from specific substrates, thereby affecting protein fate. USPs exhibit broad sequence diversity except over their catalytic cores and it has …
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Mechanism underlying linkage-selective polyubiquitin recognition
… tMIU, FAM63A also contains a catalytic domain of deubiquitylating enzymes (DUBs) that is highly specific in cleaving K48 chains. DUBs regulates Ub signalling by removing Ub from the modified proteins. In the last chapter of my thesis, I characterised the DUB activity of FAM63A beyond its …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… kinase cooperate to drive BIMEL degradation. Deubiquitylating enzymes (DUBs) remove ubiquitin from target proteins. In the context of BIMEL, DUB activity might oppose E3 ligases and thus cause its accumulation. Until recently the DUB for BIM was unknown however, USP27x has now been suggested. …
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
… Deubiquitination is carried out by the class of enzymes called deubiquitinases (DUBs). These DUBs have vital roles in the regulation of protein ubiquitination and have a profound influence on the fate of proteins and their activity. Dysregulation of DUBs has been associated with the development …