Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 253 for “"Destabilization"”.
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Messenger RNA Destabilization by -1 Programmed Ribosomal Frameshifting
… and show that they promote significant mRNA destabilization through the nonsense mediated (NMD) and no-go (NGD) decay pathways. Yeast EST2 mRNA is highly unstable and contains up to five -1 PRF signals. Ablation of the -1 PRF signals or of NMD stabilizes this mRNA. These same computational …
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Destabilization - Aggregation of Dilute Colloidal Suspensions by Polyelectrolytes
Made available in DSpace on 2014-12-08T23:57:07Z (GMT). No. of bitstreams: 1 6901367.pdf: 4933082 bytes, checksum: 40d7bcab944a80514e5f9d6b2a907b32 (MD5) Previous issue date: 1968
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Destabilization of lithium borohydride with additions of magnesium hydride
It has been shown that lithium borohydride can be destabilized with magnesium hydride additions for the purpose of reversibly hydrogen. In reactive composites of these hydrides alternative chemical pathways become available for dehydrogenation, which can modify both the thermodynamics and kinetics …
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Political Destabilization in Turkey: The Case of Journalism, 1980-2013
… in the last decade are consequences of the destabilization in power hierarchies and journalists’ interpretations of such destabilization. In the interviews, I found that journalists commonly organized their narratives about professional practice around the notions of identity, status and …
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Destabilization as Foreign Policy: The USA in Latin America, 1947-1989
… by states of risky foreign policies like destabilization (which is defined as the policy of changing the balance of power between a target government and its domestic opposition, with the aim of effecting the downfall of that target government.) Yet, history demonstrates that states …
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
… on encapsulated protein, causing structural destabilization, potential immunogenicity, and a loss of biological activity. Researchers have co-encapsulated a number of excipients to counteract PLG’s detrimental effects and protect encapsulated protein molecules, but it remains important to …
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Evaluation of parameters affecting the colloidal destabilization of spent vegetable tannin liquor
The overall objective of this investigation was to develop a chemical method for treating spent vegetable tannin liquor. Vegetable tannin wastes are plagued by a multitude of undesirable characteristics, principal of which is a color problem. Historically, chemical coagulation processes have been …
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Transnational Organized Crime and Destabilization in Democracies, Russian Organized Crime as Case Study
Transnational organized crime has been prevalent during the last century, but it recently has been recognized as a threat to the world order. Governments throughout the world, along with the intergovernmental organizations identified this phenomenon as a new threat to domestic and international …
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Investigations into the mechanism of orotidine 5'-monophosphate decarboxylase: Sources of substrate destabilization and transition state stabilization
… kinetic parameters characteristic of substrate destabilization. Substitution of these residues with hydrophilic side-chains, by providing hydrogen-bonding partners, decreased kcat by 10 to 10^4–fold. The same substitutions display very little change in the rate of product H6 exchange, supporting …
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Age differentiation of rat smooth muscle cells : altered proliferation profile, cellular changes, and implications for atherosclerotic plaque destabilization
… are at a higher risk for atherosclerotic plaque destabilization. The effect of aging on smooth muscle cells, a major cell type in the plaque, is central to the process of disease development yet is poorly understood. Therefore, we set out to study young and aged smooth muscle cells at the …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… regulate IgE production. To investigate CD23 destabilization and its effects on CD23 shedding and IgE synthesis in vivo, we utilized an anti-CD23 stalk monoclonal (19G5) which has previously been shown to enhance proteolysis of CD23 in vitro. Compared to isotype control-treated mice, mice …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
… transcripts. These sequence elements confer destabilization of transcripts by binding to AU-binding proteins (AUBPs) that can recruit cellular decay enzymes. The stability of ARE-containing mRNAs can be regulated by extracellular stimuli, which allows for cells to adapt to the changing …
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Genocídium és destabilizáció az afrikai Nagy Tavak régióban – Ajánlások a megelőzésre = Genocide and destabilization in the African Great Lakes Region Policy recommendations for prevention
Amikor a „genocídium” szót halljuk, hajlamosak vagyunk arra gondolni, hogy népirtás csak távoli helyeken fordulhat elő. Ilyenkor elfelejtjük, hogy a népirtás gyökerei, az előítéletek és a gyűlölködés, minden társadalomban jelen vannak. Általában széles körben elterjedtek az olyan nézetek, amelyek …
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Getting Campbell’s Planning Triangle Wet: Evaluating Sustainable Development in Philadelphia’s Floodplain
… the projected effects of flooding due to climate destabilization. The triangle of economic development, environmental preservation, and social equity are worthy tenants to uphold but do not prioritize relocation, an essential aspect of planning for climate destabilization. The Philadelphia …
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Destabilizing science from the right : the rhetoric of heterosexual victimage in the World Health Organization's HIV/AIDS controversy
… to the AIDS crisis. In the end, the destabilization of the meaning of HIV/AIDS does not serve emancipatory ends. Although the destabilization of meaning is the emancipatory gesture ‘par excellence’ for the poststructuralist tradition, my investigation shows that the destabilization of …
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Characterization of secondary mantle convection from geophysical data and models
… the lithosphere/asthenosphere boundary, and the destabilization of the lithosphere, induced by secondary mantle convection. Former studies, based on numerical and experimental models report that secondary convection would occur as sub-lithospheric longitudinal rolls, induced by the shear …
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Causes and consequences of soil carbon mobilization and lake brownification in northern forested landscapes
… the north, where they are leading to the faster destabilization of forest soil carbon and its mobilization as dissolved organic matter and causing the brownification of lakes. This thesis investigated the causes of soil carbon destabilization and consequences of the mobilized soil carbon to lake …
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The precision of initial context fear memory encoding determines the behavioural, cognitive and molecular changes that occur following recall
… suppressed through further experience, and the destabilization-reconsolidation sequence, a process by which memories become destabilized, strengthened, and re-consolidated following reinforcement. However, while there are hints that animals may be able to change the composition of their …
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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
… of direct BAK activation by BH3 ligands for BAK destabilization, which is a requisite for mitochondrial poration. Our high-resolution crystal structures of engineered BID BH3 ligands bound to BAK have captured the rearrangements of a buried electrostatic network at the base of hydrophobic groove, …
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Holin-dependent secretion of a large clostridial cytotoxin by C. perfringens
… two models, a pore-forming model and a membrane destabilization model that may explain the mechanism behind TpeE-dependent secretion of TpeL in C. perfringens. The pore-forming model was tested using FAST fluorescence technology and cell-surface biotinylation to determine if the amphipathic helix …
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