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Showing 1 to 12 of 12 for “"Desorption electrospray ionization"”.
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Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)
… and the applications of liquid sample desorption electrospray ionization mass spectrometry (DESI-MS), a new ambient ionization method with focus on the direct analysis of liquid samples. A variety of new applications of liquid sample DESI are discussed in details including protein …
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Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface
Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte …
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Evaluation of Ion Transfer Capillary Geometry on Sensitivity of a Desorption Electrospray Ionization and Mass Spectrometry System
… capillary geometry on the sensitivity of the Desorption Electrospray Ionization – Mass Spectrometry (DESI-MS) process. Previous work has shown that heating the ion transfer capillary to 450˚C will improve the resolution of images taken by the DESI-MS owing to increased ion desolvation. This …
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Ambient ionization - mass spectrometry: Advances toward intrasurgical cancer detection
… has focused on the development of ambient ionization – mass spectrometry (MS) for clinical measurements, specifically intrasurgical cancer detection. The molecular differences between normal and cancerous tissue were detected via direct tissue analysis in vitro by touch spray ionization …
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide Bonds
<p>Ambient mass spectrometry (MS) methods such as desorption electrospray ionization-mass spectrometry (DESI-MS) provides direct ionization of analytes with little or no sample preparation. The capability for liquidsamples analysis allows DESI-MS to be coupled with many devices such as …
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Mecanismos de tolerância e alterações metabólicas em plantas de linhaça dourada (Linum Usitatissimum L.) expostas e co-expostas a arsênio e selênio
… PSMS (paper spray mass spectrometry) e DESI-MSI (desorption electrospray ionization mass spectrometry imaging). A identificação de compostos tiólicos (fitoquelatinas e seus metabólitos) e de compostos inorgânicos e orgânicos de As e Se em extratos de raízes de plantas co-expostas foram feitas por …
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Characterization and control of lithium-ion battery interfaces
… the attempt to apply matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) to identify materials formed at cathode surfaces after cyclic voltammetry experiments. Although the method provided insight into organic components of the SEI on anodic surfaces in the past, the …
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Molecular diagnosis of cancer using ambient ionization mass spectrometry
… the development and application of ambient ionization mass spectrometry methodology and technology to the biomedical field. The primary ambient ionization method used in my studies is desorption electrospray ionization mass spectrometry (DESI-MS) imaging, which has been previously used to …
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Development of enabling technologies for single cell analysis with mass spectrometry
… cells efficiently. A variety of microprobe ionization sources are suitable for such analyses, though smaller probe footprints can utilize more densely seeded samples. This dissertation describes two technologies for performing single cell analysis with mass spectrometry. The first, …
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Mass Spectrometry Imaging: Looking Fruits at Molecular Level
… two MSI approaches, namely matrix assisted laser desorption ionization (MALDI) imaging and desorption electrospray ionization (DESI) imaging, have been evaluated and compared by mapping the localization of a range of secondary and primary metabolites in apple and grapes, respectively. The work …
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Mass spectrometry methods for imaging cellular lipids, organelles, and proteins
… interest to permit identification. For example, ionization sources that impart charges on large biomolecules without fragmentation enable the identification of unlabeled lipid species based on their exact mass. This chemical specificity is essential for the label-free detection of lipids and …
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Application of ambient mass spectrometry in electrochemical systems
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