Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Desmoplasia"”.
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Evaluation of Desmoplasia, Inflammatory Markers, and Nutritional Status for Predicting Recurrence in Low-to-Intermediate Risk Differentiated Thyroid Cancer [Valutazione di desmoplasia, markers infiammatori e stato nutrizionale per la predizione del rischio di recidiva nel carcinoma differenziato della tiroide a rischio basso-intermedio]
… Questa tesi ha valutato il ruolo della desmoplasia tumorale, di indici infiammatori e dello stato nutrizionale come possibili predittori di recidiva nei pazienti con DTC. Lo studio ha incluso 521 pazienti sottoposti a tiroidectomia totale e seguiti per almeno tre anni. La presenza e il …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… class of anti-hypertensive drugs to target tumor desmoplasia, enhance anti-tumor activity of T-lymphocytes, and prolong animal survival when combined with ICB in mouse models of mBC. Next, we investigated the effects of targeting CXCR4/CXCL12 signaling, a prominent tumor-promoting axis that …
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The desmoplastic response : mechanisms of tumour-induced fibrogenesis
The main concern of this thesis is with desmoplasia - a process in which excessive connective tissue is deposited in a neoplasm. This is a common phenomenon in neoplasia but one whose mechanisms are poorly understood. To study the process, I used a human malignant melanoma cell line (UCT-Mel 7) …
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Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
… what is known as a desmoplastic response. Desmoplasia is most often cancer promoting. Like the FBR, this response involves M1, M2a, and M2c macrophages and myofibroblasts. Increased levels and sulfation patterns of chondroitin sulfates (CS) and their associated proteoglycans are associated …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… both of which are associated with extensive desmoplasia. However, the role of αSMA+ myofibroblasts in the context of colorectal cancer has remained largely descriptive and functionally unknown. The studies outlined in this project explored the functional contribution of αSMA+ myofibroblasts …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… in pancreatic cancer patients, recognizing that desmoplasia creates significant barriers to treatment and influences interstitial fluid pressure. Our analysis of patients treated with PEGPH20, a hyaluronidase enzyme, revealed a transient reduction in velocity magnitudes one day post-treatment, …
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Single Cell Force Platforms to Link Force-ECM Coupling in Pathophysiology
… in the remodeling of the ECM and perpetuation of desmoplasia. Using NFM, seven discreet steps in formation of force-exerting PLPs anywhere along the cell body is documented, which allow cells to spread laterally and increase in contractility. Using a variety of fiber networks, it is shown that …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… used diagnoses and treatments. Also, the role of desmoplasia in pancreatic cancer progression and the therapeutics targeting the desmoplastic stroma are discussed. In Chapter 3, we report a novel biodegradable copolymer to co-deliver LY2109761 (a TGF-β receptor I/II inhibitor) and CPI-613 (a novel …
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The Recruitment and Function of Tumor Microenvironment Components During Gastric Carcinogenesis
… these results further stress the role of desmoplasia in gastric carcinogenesis. The recruitment of bone marrow derived cells may lead to the engraftment of myofibroblasts in the stem cell niche and permanently alter signals regulating stem cell homeostasis. This, in turn, may increase the …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… is a complex dynamic space which leads to desmoplasia and involved in metastasis and impediments against intracellular drug delivery. Despite extensive research efforts, there is not considerable progress in cancer therapeutics due to genomic complexity and heterogenicity of pancreatic …