Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Desipramine"”.
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Effect of acute and subchronic administration of desipramine and venlafaxine on abuse liability of heroin in rats
… of heroin in rats. The effect of venlafaxine and desipramine was investigated with aid of two behavioural techniques; an intravenous drug self-administration (IVSA) and a conditioned place preference (CPP). Because some effects of antidepressants occurs with prolonged administration, effects of …
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Effects of Alterations in Monoamine Levels on Conditioned Taste Aversions in the Rat.
… HCl and the noradrenergic uptake inhibitor desipramine in disrupting a LiCl-based conditioned taste aversion. Although both fluoxetine HCl and desipramine were effective as disruptive agents, fluoxetine was more potent than desipramine in disrupting a LiCl-based conditioned taste aversion. …
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Analysis of rat brain lipids and metabolites after antidepressant drug treatment
… drugs: the tricyclic antidepressant desipramine, and the selective serotonin re-uptake inhibitor paroxetine. The effects of the drugs in rat brain regions implicated in depression: the prefrontal cortex (PFC), hippocampus (HP) and striatum (ST) were investigated both acutely (single …
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A study of the WKY as a rat model of depression
… to an optimal dose of the antidepressant drug, desipramine in the FST. Desipramine has been shown to be effective in reducing the depression - like behaviour of WKY and was therefore chosen as the antidepressant drug for this study. A dose of 15 mg/kg desipramine attenuated the depression - like …
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Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants
… the mode of action of different ADs, fluoxetine, desipramine and agomelatine. Moreover, in order to assess the time course of ADs effects, treatments were performed for various time lengths (3,7 or 21 days). Rat hippocampal miRNome expression was investigated by means of TaqMan Rodent MicroRNA …
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
… Treatment of HIH-exposed rat pups with daily S.C Desipramine 10 mg/kg/d (an SMPD1 inhibitor) prevented up-regulated lung ceramide content, autophagy, and apoptosis. Desipramine also prevented HIH-induced lung inflammation, vascular hypoplasia and pulmonary hypertension and partially improved …
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… role in BBR3464 cellular uptake, however, desipramine, an OCT inhibitor had synergistic effects on platinun drugs-induced cytotoxicity. This effect is of high clinical relevance since desipramine, an antidepressant, is being used in prostate cancer patients for the treatment of neuropathic …
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Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
… discuss the ability of current anti-depressant desipramine to block these interactions and attenuate DO expression within the brain and periphery as a possible new mechanism by which anti-depressants may be working to reduce depression symptomology.
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… (Transport P), as the Transport P inhibitor desipramine had no effect on prazosin affinity. Taken together, these data demonstrate that numerous vasoactive neurotransmitters contribute to the overall regulation of blood flow to the teeth and oral tissues.
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Neuroendocrine mechanisms of behavioral changes induced by hypoglycemia
… with the anti-depressants (fluoxetine and desipramine) ablated the insulin-induced saccharin aversion and increased immobility in forced swim test. Taken together, these data indicate that anhedonia and depressive-like behaviors are induced by hypoglycemia and those behaviors are dependent …
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Modulation of bio-behaviors and diabesity by dietary factors
… dopamine transporters. Anti-depressants, desipramine and reboxetine, both norepinephrine re-uptake inhibitors, did not correct memory deficit in HFD-fed mice. Dietary fiber (DF) is associated with a reduction in the risk of obesity and T2D. The present study also examined the protective …
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Investigating sphingolipid behavior and function using metabolic labeling
… by RNAi or a functional pharmacologic inhibitor, desipramine, did not cause a statistically meaningful change in influenza virus entry. However, influenza virus infection itself was correlated with upregulated SMPD1 levels at the early phase of infection, opening the possibility that sphingolipids …
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Characterization of the Roman lines/strains of rats as a genetic model of psychiatric disorders: a behavioral and brain dialysis study
… immobility and also to increase climbing (desipramine) or swimming (fluoxetine) in RLA rats. Conversely, neither subacute nor chronic antidepressant treatments affected the behavior of RHA rats in the FST. iii In addition, the results of study II showed that, compared with their RLA …
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Pharmacotherapy for Social Anxiety Disorder and Posttraumatic Stress Disorder: New Meta-Analytic Approaches to Synthesising the Evidence
… Evidence was also observed for phenelzine, desipramine and risperidone for the treatment of PTSD symptoms. Mirtazapine yielded a relatively high rank for efficacy, but the respective value for acceptability was not among the best treatments. Most evidence from both NMAs was associated with …